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IL-11 R alpha

Brief Information

Name:Interleukin 11 receptor alpha
Target Synonym:Interleukin-11 Receptor Alpha Chain,Interleukin 11 Receptor Subunit Alpha,Interleukin 11 Receptor, Alpha,IL-11R-Alpha,IL-11 Receptor Subunit Alpha,Interleukin-11 Receptor Subunit Alpha,IL11RA,IL-11RA,IL-11R Subunit Alpha,CRSDA,Interleukin-11 Receptor alph
Number of Launched Drugs:9
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
ILR-H5256 Human Human IL-11 R alpha Protein, Fc Tag (MALS verified)
ILR-H5256-structure
ILR-H5256-sds
ILR-H5256-elisa_1

Part of Bioactivity data

ILR-H5256-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IL-11, His Tag (Cat. No. IL1-H5243) on HIS1K Biosensor, can bind Human IL-11 R alpha, Fc Tag (Cat. No. ILR-H5256) with an affinity constant of 0.177 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

ILR-H5256-MALS-HPLC
Human IL-11 R alpha, Fc Tag (Cat. No. ) MALS images

The purity of Human IL-11 R alpha, Fc Tag (Cat. No. ILR-H5256) was more than 85% and the molecular weight of this protein is around 145-160 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human IL-11 R alpha, Fc TagHuman IL-11 R alpha, Fc Tag (Cat. No. ILR-H5256) ELISA bioactivity

Immobilized Human IL-11, His Tag (Cat. No. IL1-H5243) at 5 μg/mL (100 μL/well) can bind Human IL-11 R alpha, Fc Tag (Cat. No. ILR-H5256) with a linear range of 1-10 ng/mL (QC tested).

Synonym Name

IL-11 R alpha,IL-11 RA,IL11RA,Interleukin-11 receptor subunit alpha,IL-11 receptor subunit alpha,IL-11R subunit alpha,IL-11R-alpha

Background

Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.

Clinical and Translational Updates

    Public Drug Information

    Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
    Recombinant human interleukin-11 (Diao group) Approved Chengdu Diao Jiuhong Pharmaceutical Factory 依星 Mainland China Thrombocytopenia Chengdu Diao Jiuhong Pharmaceutical Factory 2003-04-23 Thrombocytopenia Details
    Recombinant human interleukin-11 (Shanghai CP Guojian) Approved Shanghai Cp Guojian Pharmaceutical Co Ltd 欣美格 Mainland China Thrombocytopenia Shanghai Cp Guojian Pharmaceutical Co Ltd 2005-04-26 Thrombocytopenia Details
    Recombinant human interleukin 11 (BioGeneric Pharma) Approved Biogeneic Pharma Thrombocytopenia Details
    Recombinant human interleukin-11 (Kerun Biopharmaceutical) Approved Chongqing Kerun Biologic Pharmaceutical Development Co Ltd 百杰依 Mainland China Thrombocytopenia China Resources Angde Biotech Pharma Co Ltd 2008-05-08 Thrombocytopenia Details
    Recombinant human interleukin-11 (Xiamen Amoytop Biotech) rHuIL-11 Approved Xiamen Amoytop Biotech Co Ltd 特尔康 Mainland China Thrombocytopenia Xiamen Amoytop Biotech Co Ltd 2005-04-11 Thrombocytopenia Details
    Recombinant human interleukin-11 (Qilu Pharmaceutical) Approved Qilu Pharmaceutical Co Ltd 巨和粒 Mainland China Thrombocytopenia Qilu Pharmaceutical Co Ltd 2003-03-18 Thrombocytopenia Details
    Recombinant human interleukin-11 (Beijing ShuangLu Pharmaceutical) Approved Beijing Sl Pharmaceutical Co Ltd 迈格尔 Mainland China Thrombocytopenia Beijing Sl Pharmaceutical Co Ltd 2003-03-17 Thrombocytopenia Details
    Oprelvekin biosimilar (Hangzhou Jiuyuan Gene Engineering) Approved Hangzhou Jiuyuan Gene Engineering Co Ltd 吉巨芬, Jijufen Mainland China Thrombocytopenia Hangzhou Jiuyuan Gene Engineering Co Ltd 2003-09-18 Thrombocytopenia Details
    Recombinant human interleukin-11 for injection Approved Details
    Recombinant human interleukin-11 (Hangzhou Jiuyuan Gene Engineering Co Ltd ) Approved Hangzhou Jiuyuan Gene Engineering Co Ltd Thrombocytopenia Details

    Clinical Drug Information

    Name Research Code Research Phase Company Indications Clinical Trials
    Δ1-9, alanine 10, asparagine 134, recombinant human interleukin-11 Phase 3 Clinical Fuzhou Quanye Economic Technology Co Ltd Thrombocytopenia Details

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