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Your Position: Home > latent GDF-8

latent GDF-8

Brief Information

Name:Growth/differentiation factor 8
Target Synonym:MSTN,GDF-8,GDF8,Growth Differentiation Factor 8,MSLHP,Myostatin,Growth/Differentiation Factor 8
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
GD8-H5243 Human Human latent GDF-8 Protein, His Tag (MALS verified)
ACRO Quality

Part of Bioactivity data

 Latent GDF-8 SPR

Human Follistatin Protein, His Tag, premium grade (Cat. No. FON-H52H4) immobilized on CM5 Chip can bind Human latent GDF-8, His Tag (Cat. No. GD8-H5243) with an affinity constant of 364 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Latent GDF-8 MALS images

The purity of Human latent GDF-8, His Tag (Cat. No. GD8-H5243) is more than 90% and the molecular weight of this protein is around 80-95 kDa verified by SEC-MALS.

Synonym Name

latent GDF-8, GDF-8, Myostatin, GDF8, MSTN, Growth/differentiation factor 8


Growth differentiation factor 8 (GDF8), also known as myostatin, is a unique member of the transforming growth factor-β superfamily that is expressed in human granulosa cells and has important roles in regulating a variety of ovarian functions. GDF8 acts as a negative regulator of skeletal muscle growth and differentiation. In addition to the expression in the musculoskeletal system, GDF8 is also expressed in various tissues, including the reproductive system.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Talditercept alfa RO-7239361; BMS-986089; RG-6206; BHV-2000 Phase 3 Clinical Bristol-Myers Squibb Company Muscular Dystrophy, Duchenne; Neuromuscular Diseases; Muscular Atrophy, Spinal Details
Apitegromab SRK-015 Phase 3 Clinical Scholar Rock Spinal Muscular Atrophies of Childhood; Neuromuscular Manifestations; Muscular Atrophy; Neuromuscular Diseases; Muscular Atrophy, Spinal; Atrophy Details
RO-7204239 GYM-329; RO-7204239; RG-6237; RG-70240 Phase 3 Clinical F. Hoffmann-La Roche Ltd, Chugai Pharmaceutical Co Ltd Muscular Dystrophy, Facioscapulohumeral; Muscular Atrophy, Spinal Details
Trevogrumab REGN-1033; REGN1033; SAR-391786; GDF8 Phase 2 Clinical Regeneron Pharmaceuticals Inc Myositis, Inclusion Body; Obesity; Sarcopenia Details
AAV1-FS344 AAV1-Follistatin; AAV1-FS344 Phase 2 Clinical Nationwide Children'S Hospital Becker muscular dystrophy; Myositis, Inclusion Body; Muscular Dystrophy, Duchenne Details
ACE-2494 ACE-2494 Phase 1 Clinical Acceleron Pharma Inc Details
KER-065 KER-065; RKER-065 Phase 1 Clinical Keros Therapeutics Inc Neuromuscular Diseases; Obesity Details

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