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Your Position: Home > latent GDF-8

latent GDF-8

Brief Information

Name:Growth/differentiation factor 8
Target Synonym:MSTN,GDF-8,GDF8,Growth Differentiation Factor 8,MSLHP,Myostatin,Growth/Differentiation Factor 8
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:NDA/BLA

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Cat. No. Species Product Description Structure Purity Feature
GD8-C82Q3 Cynomolgus Biotinylated Cynomolgus latent GDF-8 Protein, Avitag™,His Tag
GD8-C82Q3-structure
GD8-C82Q3-sds
GD8-C5243 Cynomolgus Cynomolgus Latent GDF-8 Protein, His Tag
GD8-C5243-structure
GD8-C5243-sds
GD8-M5243 Mouse Mouse latent GDF-8 Protein, His Tag
GD8-M5243-structure
GD8-M5243-sds
GD8-M82Q3 Mouse Biotinylated Mouse latent GDF-8 Protein, Avitag™,His Tag
GD8-M82Q3-structure
GD8-M82Q3-sds
GD8-H82Q3 Human Biotinylated Human latent GDF-8 Protein, His,Avitag™
GD8-H82Q3-structure
GD8-H82Q3-sds
GD8-H8243 Human Biotinylated Human latent GDF-8 Protein, His Tag, ultra sensitivity (primary amine labeling) (pro & latent) (MALS & SPR verified)
GD8-H8243-structure
GD8-H8243-sds
GD8-H5343 Human Human latent GDF-8 Protein, His Tag (MALS verified)
GD8-H5343-sds
GD8-H5243 Human Human latent GDF-8 Protein, His Tag (pro & latent) (MALS verified)
GD8-H5243-structure
GD8-H5243-sds
ACRO Quality

Part of Bioactivity data

GD8-C5243-SPR
latent GDF-8 SPR

Apitegromab captured on Protein A Chip can bind Cynomolgus Latent GDF-8 Protein, His Tag (Cat. No. GD8-C5243) with an affinity constant of 5.41 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
GD8-M5243-SPR
latent GDF-8 SPR

Apitegromab captured on Protein A Chip can bind Mouse latent GDF-8 Protein, His Tag (Cat. No. GD8-M5243) with an affinity constant of 16.1 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

latent GDF-8, GDF-8, Myostatin, GDF8, MSTN, Growth/differentiation factor 8

Background

Growth differentiation factor 8 (GDF8), also known as myostatin, is a unique member of the transforming growth factor-β superfamily that is expressed in human granulosa cells and has important roles in regulating a variety of ovarian functions. GDF8 acts as a negative regulator of skeletal muscle growth and differentiation. In addition to the expression in the musculoskeletal system, GDF8 is also expressed in various tissues, including the reproductive system.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Talditercept alfa RO-7239361; BMS-986089; RG-6206; BHV-2000 Phase 3 Clinical Bristol-Myers Squibb Company Muscular Dystrophy, Duchenne; Neuromuscular Diseases; Muscular Atrophy, Spinal Details
RO-7204239 GYM-329; RO-7204239; RG-6237; RG-70240 Phase 3 Clinical F. Hoffmann-La Roche Ltd, Chugai Pharmaceutical Co Ltd Muscular Dystrophy, Facioscapulohumeral; Muscular Atrophy, Spinal Details
Trevogrumab REGN-1033; REGN1033; SAR-391786; GDF8 Phase 2 Clinical Regeneron Pharmaceuticals Inc Myositis, Inclusion Body; Obesity; Sarcopenia Details
AAV1-FS344 AAV1-Follistatin; AAV1-FS344 Phase 2 Clinical Nationwide Children'S Hospital Becker muscular dystrophy; Myositis, Inclusion Body; Muscular Dystrophy, Duchenne Details
KER-065 KER-065; RKER-065 Phase 1 Clinical Keros Therapeutics Inc Neuromuscular Diseases; Obesity Details
HS135 HS-135 Phase 1 Clinical 35Pharma Inc Hypertension, Pulmonary; Pulmonary Arterial Hypertension Details

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