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Your Position: Home > FGF-21

FGF-21

Brief Information

Name:Fibroblast growth factor 21
Target Synonym:FGF21
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
FG1-H5243 Human Human FGF-21 Protein, His Tag
FG1-H5243-structure
FG1-H5243-sds

Synonym Name

FGF-21, FGF21

Background

Fibroblast growth factor 21 (FGF21), which stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression. FGF21 has been shown to protect animals from diet-induced obesity when overexpressed in transgenic mice. It also lowers blood glucose and triglyceride levels when administered to diabetic rodents, suggesting it may exhibit the therapeutic characteristics necessary for effective treatment of diabetes. Treatment of animals with FGF21 results in increased energy expenditure, fat utilisation and lipid excretion. FGF21 is most abundantly expressed in the liver, and also expressed in the thymus at lower levels.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
HEC-88473 HEC-88473 Phase 1 Clinical Dongguan City Hec Biological Medicine Res And Development Co Ltd Non-alcoholic Fatty Liver Disease; Diabetes Mellitus, Type 2; Obesity Details
AP-026 AP-026 Phase 1 Clinical Anyuan Pharmaceutical Technology (Shanghai) Co Ltd Non-alcoholic Fatty Liver Disease Details
BOS-580 Novartis Pharma Ag Details
Pegozafermin BIO89-100; TEV-47948 89bio, Teva Details
Recombinant human FGF21 Fc fusion protein(Anyuan Pharmaceutical) AP-025 Phase 1 Clinical Anyuan Pharmaceutical Technology (Shanghai) Co Ltd Non-alcoholic Fatty Liver Disease Details

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