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Brief Information

Name:DNA (cytosine-5)-methyltransferase 1
Target Synonym:Dnmt1,AIM,MCMT,DNA methyltransferase HsaI,DNA Methyltransferase 1,CXXC-Type Zinc Finger Protein 9,DNA MTase HsaI,M.HsaI,CXXC9,EC:,DNA (Cytosine-5-)-Methyltransferase 1,DNMT,DNA (Cytosine-5)-Methyltransferase 1,EC,ADCADN,HSN1E
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CD9-H5222 Human Human CD69 / CLEC2C Protein, His Tag
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Synonym Name



Early activation antigen CD69 is also known as C-type lectin domain family 2 member C (CLEC2C), Activation inducer molecule (AIM), Early T-cell activation antigen p60, Leukocyte surface antigen Leu-23. CD69 contains one C-type lectin domain. CD69 / CLEC2C is expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets. CD69 is induced by antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes and by interaction of IL-2 with the p75 IL-2R on the surface of NK cells. CD69 / CLEC2C involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Triclabendazole EGA-230B; CGA-89317; NVP-EGA230 Approved Novartis Pharma Ag Egaten, Fasinex, Triclathera Iran Fascioliasis Novartis Pharma Ag 1989-01-01 Fascioliasis Details
Mecobalamin E-0302 Approved Myelogen, Naso B12, NASOCOBAL, Methycobal, 弥尔神, 悦敏兴, RHINOCOBAL, 奇信, 曲力, 弥可保 Peripheral Nervous System Diseases; Autistic Disorder; Neuralgia; Neuritis; Vitamin B 12 Deficiency; Amyotrophic Lateral Sclerosis; Fibromyalgia Details
Decitabine/Cedazuridine ASTX-727; E-7727/decitabine; Decitabine/E7727 Approved Astex Pharmaceuticals Inc Inqovi United States Myelodysplastic Syndromes Otsuka Pharmaceutical Co Ltd 2020-07-07 Leukemia, Myelogenous, Chronic; Solid tumours; Leukemia; Myelodysplastic Syndromes; Myeloproliferative Disorders; Leukemia, Myelomonocytic, Chronic; Triple Negative Breast Neoplasms; Neoplasms; Breast Neoplasms; Leukemia, Myeloid, Acute; Glioma; Nervous System Neoplasms; Neurilemmoma Details
Decitabine AzadC; E-7373; 5-aza-CdR; DAC; NSC-127716 Approved Eisai Co Ltd 达珂, Dacogen Mainland China Myelodysplastic Syndromes Mgi Pharma Inc 2006-05-02 Burkitt Lymphoma; Neuroblastoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Breast Neoplasms; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Vulvar Neoplasms; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Primary Myelofibrosis; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Thyroid Neoplasms; Adenocarcinoma, Follicular; Lymphoma; Lymphoma, Non-Hodgkin; Carcinoma, Non-Small-Cell Lung; Anemia, Sickle Cell; Melanoma; Leukemia, Lymphocytic, Chronic, B-Cell; Breast Neoplasms, Male; Neoplasm Metastasis; Precancerous Conditions; Myelodysplastic-Myeloproliferative Diseases; Thyroid Cancer, Papillary; Leukemia, Myelomonocytic, Chronic; Purpura, Thrombocytopenic, Idiopathic; Liver Neoplasms; Leukemia, Myelogenous, Chronic; Leukemia, Promyelocytic, Acute; Leukemia, Myeloid, Accelerated Phase; Solid tumours; Lymphoma, B-Cell, Marginal Zone; Thalassemia; Esophageal Neoplasms; Neutropenia; Myelodysplastic Syndromes; Leukemia; Myeloproliferative Disorders; Neoplasms; Lymphoma, Large B-Cell, Dif Details
Azacitidine NSC-102816; 5-aza-CR; CC-486; NS-17; U-18496; NEX-18; NEX-18a Approved Celgene Corp 维达莎, Vidaza, Onureg United States Myelodysplastic Syndromes Celgene Corp 2004-05-19 Leukemia, Myeloid, Acute; Immune System Diseases; Breast Neoplasms; Sarcoma; Osteosarcoma; Prostatic Neoplasms; Brain Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tuberculosis, Pulmonary; Primary Myelofibrosis; Hepatic Insufficiency; Multiple Myeloma; Lymphoma, Non-Hodgkin; Thyroid Neoplasms; Leukemia, Myelomonocytic, Juvenile; Lymphoma; Lung Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Large Granular Lymphocytic; Myelodysplastic-Myeloproliferative Diseases; Nasopharyngeal Neoplasms; Solid tumours; Hematologic Neoplasms; Leukemia; Ependymoma; Leukemia, Myeloid; Head and Neck Neoplasms; Intestinal Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Myelodysplastic Syndromes; Leukemia, Myelogenous, Chronic; Hodgkin Disease; Leukemia, Myelomonocytic, Chronic; Myeloproliferative Disorders; Glioblastoma; Neoplasms; Small Cell Lung Carcinoma; Lymphoma, Large B-Cell, Diffuse; beta-Thalassemia; Plasmacytoma Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
NTX-301 NTX-303 Phase 1 Clinical Southern Research Institute, Pinotbio Inc Ovarian Neoplasms; Solid tumours; Neoplasms; Carcinoma, Transitional Cell; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Glioma; Leukemia, Myeloid, Acute Details
Decitabine/Tetrahydrouridine EPI-01 Phase 2 Clinical Epicdestiny Anemia, Sickle Cell Details
Azacitidine/Cedazuridine ASTX-030 Phase 3 Clinical Otsuka Pharmaceutical Co Ltd Leukemia, Myelogenous, Chronic; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
FdCyd NSC-48006; Ro-5-1090 Phase 2 Clinical City Of Hope National Medical Center, National Cancer Institute Head and Neck Neoplasms; Esophageal Neoplasms; Neoplasms; Myelodysplastic Syndromes; Urinary Bladder Neoplasms; Mesothelioma; Breast Neoplasms; Lung Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung Details
Guadecitabine Sodium S-110; 0RB89YH367 (UNII code); SGI-110 Phase 2 Clinical Otsuka Holdings Co Ltd Prostatic Neoplasms, Castration-Resistant; Melanoma; Paraganglioma; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Carcinoma, Hepatocellular; Lung Neoplasms; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Leukemia, Myeloid, Acute; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Peritoneal Neoplasms; Cholangiocarcinoma; Ovarian Neoplasms; Klatskin Tumor; Small Cell Lung Carcinoma; Carcinoma, Transitional Cell; Myeloproliferative Disorders; Pancreatic Neoplasms; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Carcinoma, Renal Cell; Pheochromocytoma; Stomach Neoplasms; Chondrosarcoma; Kidney Neoplasms Details
EF-009 EF-009 Phase 2 Clinical Everfront Biotech Co Ltd Pancreatic Neoplasms Details
Curcumin VOLT-03; VOLT-3; NSC-32982 Phase 3 Clinical University Of Pennsylvania Renal Insufficiency, Chronic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Breast Neoplasms; Oral Submucous Fibrosis; Tobacco Use Disorder; Cardiovascular Diseases; Cognitive Dysfunction; Neuralgia; Colorectal Neoplasms; Cervical Intraepithelial Neoplasia; Uterine Cervical Dysplasia; Cigarette Smoking; Asthma; Chronic Periodontitis; Lung Neoplasms; Lichen Planus, Oral; Adenocarcinoma, Mucinous; Inflammation; Osteoarthritis; Aortic Aneurysm, Abdominal; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Non-Small-Cell Lung; Crohn Disease; Adenocarcinoma; Uterine Cervical Neoplasms; Neoplasm Metastasis; Macular Degeneration; Neoplasms; Drug-Related Side Effects and Adverse Reactions; Adenomatous Polyposis Coli; Optic Atrophy, Hereditary, Leber; Digestive System Diseases; Depression; Non-alcoholic Fatty Liver Disease; Diabetes Mellitus, Type 2; Gastritis, Atrophic; Radiodermatitis; Pain; Spasm; Rectal Neoplasms; Atherosclerosis; Primary Dysautonomias; Arthritis, Rheumatoid; Spondylitis, An Details

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