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Your Position: Home > IFN-alpha 2b

IFN-alpha 2b

Brief Information

Name:Interferon alpha-2
Target Synonym:IFNA2B,IFNA2C,LeIF A,Interferon alpha-2,IFN-alpha-2,IFNA2,Interferon Alpha 2,Alpha-2a Interferon,Interferon Alpha 2b,Interferon Alpha A,Interferon Alpha 2a,Interferon Alpha-A,IFN-AlphaA,IFNA2A,INFA2,IFNA
Number of Launched Drugs:13
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
IFB-H5253 Human Human IFN-alpha 2b (K46R) Protein, Fc Tag (MALS verified)
IFB-H5253-structure
IFB-H5253-sds
IFB-H5253-elisa_1

Part of Bioactivity data

IFB-H5253-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IFNAR2, His Tag (Cat. No. IF2-H5224) on HIS1K Biosensor, can bind Human IFN-alpha 2b (K46R), Fc Tag (Cat. No. IFB-H5253) with an affinity constant of 0.329 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

IFB-H5253-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human IFNAR1, His Tag (Cat. No. IF1-H5225) on NTA Biosensor, can bind Human IFN-alpha 2b (K46R), Fc Tag (Cat. No. IFB-H5253) with an affinity constant of 0.689 μM as determined in BLI assay (ForteBio Octet Red96e) (Rountinely tested).

Synonym Name

IFN-alpha 2b,IFNA2B,IFN-alpha 2 (alpha 2b),interferon alpha 2b

Background

IFN-alpha is a cytokine that has an immunomodulatory function. It plays an important role not only in antiviral activity but also in several physiologic functions, such as activation of dendritic cells and accelerated expression of major histocompatibility complex I and II molecules that may cause increased antigen presentation. Variants of human leukocyte interferon alpha 2 (IFN-alpha 2a, alpha 2b, and alpha 2c) differ from each other by changes in their coding regions at nucleotide positions 137 and 170. IFN-alpha 2b (IFNα-2b) is an important cytokine and used for antiviral and anticancer treatment.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Interferon alfa-2a biosimilar (BioGeneric Pharma) Approved Biogeneric Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Hairy Cell; Hepatitis C; Sarcoma, Kaposi Details
Interferon alfa-2b biosimilar (Virchow Group) Approved Virchow Group Hepatitis B; Hepatitis C Details
Interferon alfa-2b biosimilar (BioGeneric) Approved Biogeneric Egypt Hepatitis B; Hepatitis C; Neoplasms Biogeneric 2013-05-01 Neoplasms; Hepatitis B; Hepatitis C Details
Recombinant Human Interferon α2a (Wuhan Wei'Ao) Approved Wuhan Wei'Ao Pharmaceutical Co Ltd 奥平 Mainland China Virus Diseases Wuhan Wei'Ao Pharmaceutical Co Ltd 1998-01-01 Virus Diseases Details
Interferon alfa-2b (Changchun Heber) rHuIFNa-2b Approved Changchun Heber Biological Technology Co Ltd Mainland China Virus Diseases; Neoplasms Changchun Heber Biological Technology Co Ltd 2006-01-01 Virus Diseases; Neoplasms Details
Peginterferon alpha-2b biosimilar (Zydus Cadila) Approved Zydus Cadila Japan Condylomata Acuminata; Hepatitis B; Hepatitis C Zydus Cadila 2014-01-01 Hepatitis B; Hepatitis C; Condylomata Acuminata Details
Interferon-alpha 2 (CJ Corporation) Approved Cj Leukemia, Hairy Cell; Carcinoma, Renal Cell; Multiple Myeloma; Hepatitis B; Hepatitis C; Sarcoma, Kaposi; Melanoma Details
Interferon alfa-2b biosimilar (PT Kalbe) Approved Kalbe Farma Kalferon Hepatitis B; Hepatitis C; Lymphoma, Non-Hodgkin; Melanoma Details
Peginterferon alfa-2a (Pooyesh Darou Pharmaceuticals) Approved Pooyesh Darou Iran Hepatitis B; Hepatitis C Pooyesh Darou 2008-01-01 Hepatitis B; Hepatitis C Details
Recombinant interferon alpha-2a (Changchun ChangSheng Gene Pharmaceutical) Approved Changchun Changsheng Gene Pharmaceutical Stock Co Ltd 忆林, Yilin Mainland China Condylomata Acuminata; Herpes Simplex Changchun Changsheng Gene Pharmaceutical Stock Co Ltd 2004-09-14 Herpes Simplex; Condylomata Acuminata Details
Interferon alpha-2b biosimilar (PharmBiotek) Approved Pharmbiotek Laferon, Laferonum Ukraine Pharmbiotek 2004-01-01 Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Ovarian Neoplasms; Bone Marrow Neoplasms; Leukemia, Hairy Cell; Carcinoma, Renal Cell; Sepsis; Papillomavirus Infections; Herpesviridae Infections; Urinary Bladder Neoplasms; Multiple Sclerosis; Hepatitis B; Chlamydia Infections; Breast Neoplasms; Lymphoma, Non-Hodgkin; Sarcoma, Kaposi; Melanoma Details
Recombinant human interferon alpha-1b (Beijing Tri-Prime Genetic Engineering) Approved Beijing Tri-Prime Gene Pharmaceutical Co Ltd 运德素, YunDeSu Mainland China Virus Diseases; Neoplasms Beijing Tri-Prime Gene Pharmaceutical Co Ltd 1999-01-01 Pneumonia; Virus Diseases; Neoplasms; Bronchiolitis; Respiratory Syncytial Virus Infections Details
Interferon alfa-2b biosimilar (Pooyesh Darou Pharmaceuticals) Approved Pooyesh Darou PDferon-B Iran Hepatitis B; Hepatitis C; Leukemia, Hairy Cell; Lymphoma, Follicular; Melanoma; Multiple Myeloma; Malignant Carcinoid Syndrome Pooyesh Darou 2012-09-01 Leukemia, Hairy Cell; Malignant Carcinoid Syndrome; Multiple Myeloma; Hepatitis B; Lymphoma, Follicular; Hepatitis C; Melanoma Details
Interferon alfa-2b biosimilar (CIGB/Heber Biotec) Approved Center For Genetic Engineering And Biotechnology Inrec, Heberon Alfa R Uruguay Virus Diseases Heber Biotec 2000-12-01 Virus Diseases Details
Recombinant interferon alpha-2a (Shanghai Tenry) Approved Shanghai Tenry Pharmaceutical Co Ltd 万复洛 Mainland China Neoplasms; Virus Diseases Shanghai Tenry Pharmaceutical Co Ltd 2000-01-01 Neoplasms; Virus Diseases Details
Interferon alfa-2b (Anhui Anke Biotechnology) rHuIFNa-2b Approved Anhui Anke Biotechnology (Group) Co Ltd 安达芬 Mainland China Condylomata Acuminata; Hepatitis B; Herpes Simplex; Herpes Zoster; Herpes Zoster Ophthalmicus; Papillomavirus Infections; Hepatitis C; Leukemia, Hairy Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Uterine Cervical Erosion Anhui Anke Biotechnology (Group) Co Ltd 1997-01-01 Herpes Simplex; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Herpes Zoster Ophthalmicus; Leukemia, Hairy Cell; Papillomavirus Infections; Herpangina; Uterine Cervical Erosion; Hepatitis B; Hepatitis C; Condylomata Acuminata; Herpes Zoster Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Peginterferon alfa-2a follow-on biologic (Biocad) BCD-081 Clinical Biocad Hepatitis C Details
GSK-2245035 GSK-2245035 Phase 2 Clinical Glaxosmithkline Plc Rhinitis, Allergic, Seasonal; Rhinitis, Allergic; Asthma; Rhinitis Details
SFR-9216 SFR-9216 Phase 1 Clinical Tianjin Puying Biotechnology Co Ltd Hepatitis B Details
Q101-pegylated recombinant human interferon alpha-2a (Shijiazhuang Zhongqi Pharmaceutical) Q-101 (Shijiazhuang Zhongqi Pharmaceutical); PEG-IFN-α-2a Phase 1 Clinical Cspc Pharmaceutical Technology (Shijiazhuang) Co Ltd Hepatitis B Details
Recombinant human serum albumin-interferon-alpha-2a fusion protein (Qilu Pharmaceutical) Phase 1 Clinical Qilu Pharmaceutical Co Ltd, Institute Of Bioengineering Chinese Academy Of Military Medical Sciences Hepatitis B, Chronic; Hepatitis B Details

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