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Your Position: Home > IFN-alpha 2b

IFN-alpha 2b

Brief Information

Name:Interferon alpha-2
Target Synonym:IFNA2B,IFNA2C,LeIF A,Interferon alpha-2,IFN-alpha-2,IFNA2,Interferon Alpha 2,Alpha-2a Interferon,Interferon Alpha 2b,Interferon Alpha A,Interferon Alpha 2a,Interferon Alpha-A,IFN-AlphaA,IFNA2A,INFA2,IFNA
Number of Launched Drugs:16
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Preclinical

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Cat. No. Species Product Description Structure Purity Feature
IFB-H5253 Human Human IFN-alpha 2b (K46R) Protein, Fc Tag (MALS verified)
IFB-H5253-structure
IFB-H5253-sds

Part of Bioactivity data

IFB-H5253-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IFN-alpha 2b (K46R), Fc Tag (Cat. No. IFB-H5253) immobilized on CM5 Chip can bind Human IFNAR2, His Tag (Cat. No. IF2-H5224) with an affinity constant of 0.257 μM as determined in SPR assay (Biacore T200) (Routinely tested).

IFB-H5253-MALS-HPLC
Human IFN-alpha 2b (K46R), Fc Tag (Cat. No. ) MALS images

The purity of Human IFN-alpha 2b (K46R), Fc Tag (Cat. No. IFB-H5253) is more than 90% and the molecular weight of this protein is around 95-105 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human IFN-alpha 2b (K46R), Fc TagHuman IFN-alpha 2b (K46R), Fc Tag (Cat. No. IFB-H5253) ELISA bioactivity

Immobilized Human IFNAR2, His Tag (Cat. No. IF2-H5224) at 5 μg/mL (100 μL/well) can bind Human IFN-alpha 2b (K46R), Fc Tag (Cat. No. IFB-H5253) with a linear range of 2.4-10 ng/mL (QC tested).

Synonym Name

IFN-alpha 2b,IFNA2B,IFN-alpha 2 (alpha 2b),interferon alpha 2b

Background

IFN-alpha is a cytokine that has an immunomodulatory function. It plays an important role not only in antiviral activity but also in several physiologic functions, such as activation of dendritic cells and accelerated expression of major histocompatibility complex I and II molecules that may cause increased antigen presentation. Variants of human leukocyte interferon alpha 2 (IFN-alpha 2a, alpha 2b, and alpha 2c) differ from each other by changes in their coding regions at nucleotide positions 137 and 170. IFN-alpha 2b (IFNα-2b) is an important cytokine and used for antiviral and anticancer treatment.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SAR-441000 SAR441000; SAR-441000; BNT-131 Biontech Se, Sanofi Details

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