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Your Position: Home > Claudin-18.2

Claudin-18.2

Brief Information

Name:Claudin-18 splice variant 2
Target Synonym:UNQ778/PRO1572,CLDN18,Claudin 18,Surfactant Associated Protein J,Surfactant, Pulmonary Associated Protein J,Surfactant Associated 5,Claudin-18,SFTA5,SFTPJ,Claudin 18.2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:18
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

CL2-H5547-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human Claudin-18.2 Full Length Protein-VLP (Cat. No. CL2-H5547) captured on CM5 Chip via Anti-Claudin-18.2 antibody can bind Anti-Claudin-18.2 antibody with an affinity constant of 1.24 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

CL2-H5546-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human Claudin-18.2, His Tag (Cat. No. CL2-H5546) captured on CM5 chip via anti-His antibody can bind Monoclonal Anti-Chimeric Claudin-18.2 Antibody, Human IgG1 with an affinity constant of 3.55 nM as determined in a SPR assay (in presence of DDM and CHS) (Biacore T200) (Routinely tested).

Synonym Name

Claudin-18.2,CLDN18,Claudin-18

Background

Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Zolbetuximab GC-182; iMAB-362 Phase 3 Clinical Ganymed Lymphangioma, Cystic; Solid tumours; Stomach Neoplasms; Esophageal Neoplasms; Gastrointestinal Diseases; Pain; Pancreatic Neoplasms; Adenocarcinoma Details
Recombinant humanized anti-Claudin 18.2 monoclonal antibody (CARsgen) AB-011 Phase 1 Clinical Kaixing Life Technology (Shanghai) Co Ltd, Carsgen Biomedicine (Shanghai) Co Ltd Solid tumours; Stomach Neoplasms; Pancreatic Neoplasms Details
KD-022 (Nanjing KAEDI Biotech) KD-022; KD-182 Phase 1 Clinical Nanjing Kaedi Biotechnology Co Ltd Neoplasms Details
LCAR-C18S CAR-T cell therapy LB-1904; LB1904 Phase 1 Clinical Nanjing Legend Biotechnology Co Ltd Stomach Neoplasms Details
Q-1802 Q-1802 Phase 1 Clinical Qiyu Biotechnology (Shanghai) Co Ltd Solid tumours Details
Recombinant humanized monoclonal antibody MIL93(Mabworks) Phase 1 Clinical Beijing Mabworks Biotech Co Ltd Solid tumours; Neoplasms Details
ATG022 ATG-022; ATG022 Clinical Antengene Corporation (Shanghai) Ltd Solid tumours Details
M-108 M108; M-108 Phase 1 Clinical Solid tumours; Gastrointestinal Neoplasms Details
AMG-910 AMG-910 Phase 1 Clinical Amgen Inc Esophageal Neoplasms; Stomach Neoplasms; Adenocarcinoma Details
ASKB-589 ASKB-589 Phase 2 Clinical Jiangsu Aosaikang Pharmaceutical Co Ltd Solid tumours; Pancreatic Neoplasms; Adenocarcinoma Details
QL-1779 QL-1779; QL1779 Phase 1 Clinical Qilu Pharmaceutical Co Ltd Solid tumours Details
TJ-CD4B TJ-CD4B; ABL-111; TJ-CLDN4B; TJ-033721 Phase 1 Clinical Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Esophageal adenocarcinoma; Carcinoma, Pancreatic Ductal; Neoplasm Metastasis Details
CMG-901 CMG901 Phase 1 Clinical Connaught Biomedical Technology (Chengdu) Co Ltd Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Adenocarcinoma Details
LM-302 LM-302; LM302 Phase 2 Clinical Eli Lilly Trading (Shanghai) Co Ltd Solid tumours; Gastrointestinal Neoplasms Details
SYSA-1801 SYSA1801; CPO-102; SYSA-1801 Phase 1 Clinical Solid tumours Details
Claudin18.2 (CLDN18.2) humanized monoclonal antibody(Mabspacebio) TST-001 Phase 1 Clinical Mabspace Biosciences, Hangzhou Just Biotherapeutics Co Ltd Solid tumours; Biliary Tract Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Neoplasms; Lung Neoplasms; Gallbladder Neoplasms Details
LM-102 LM-102 Phase 2 Clinical LaNova Medicines Ltd Solid tumours Details
NBL-015 NBL-015 Phase 1 Clinical Shanghai Xinshi Biological Medicine Co Ltd Solid tumours; Stomach Neoplasms; Pancreatic Neoplasms Details

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