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CD89

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Cat. No. Species Product Description Structure Purity Feature
CD9-H52Ha Human Human CD89 / FCAR Protein, His Tag (MALS verified)
CD9-H52Ha-structure
CD9-H52Ha-sds

Part of Bioactivity data

The purity of Human CD89, His Tag (Cat. No. CD9-H52Ha) is more than 90% and the molecular weight of this protein is around 35-45 kDa verified by SEC-MALS.

  • Background
    CD89 (Fc alphaRI) is the human myeloid IgA Fc receptor expressed on cells, such as neutrophils, eosinophils and monocytes/macrophages. Cross-linking of CD89 on these cells, by IgA-opsonised particles (e.g. bacteria, viruses) or anti-CD89 monoclonal antibodies, can trigger various immunological effector functions which are generally protective but may also cause harm to the body. CD89 is a transmembrane glycoprotein that binds both subclasses of IgA in all its molecular forms (i.e. monomeric, dimeric and secretory IgA) via a region of its membrane-distal EC1 domain. DNA studies have shown that the CD89 gene is located within the newly described leukocyte receptor cluster (LRC) on chromosome 19. CD89 is more closely related to the KIR and MIR proteins, whose genes are also found in the LRC, than to other human Fc receptors (FcRs).
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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