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Your Position: Home > Latent TGF-beta 2

Latent TGF-beta 2

Brief Information

Name:Transforming growth factor beta 2
Target Synonym:TGF-beta-2,BSC-1 Cell Growth Inhibitor,Polyergin,Glioblastoma-Derived T-Cell Suppressor Factor,Cetermin,LDS4,TGFB2,Transforming Growth Factor, Beta 2,Transforming Growth Factor Beta-2 Proprotein,TGF-Beta2,Transforming Growth Factor Beta 2,G-TSF,Transforming Growth Factor beta2,LAP,Prepro-Transforming Growth Factor Beta-2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
TG2-H5243 Human Human Latent TGF-beta 2 / TGFB2 Protein, His Tag
TG2-H5243-structure
TG2-H5243-sds
ACRO Quality

Part of Bioactivity data

TG2-H5243-ELISA
 Latent TGF-beta 2 ELISA

Immobilized Human Latent TGFB2, His Tag (Cat. No. TG2-H5243) at 5 μg/mL (100 μL/well) can bind Human LRRC32, Fc Tag (Cat. No. LR2-H5256) with a linear range of 0.039-0.625 μg/mL (QC tested).

Synonym Name

Latent TGFB2,MGC116892,TGFβ2,TGF-beta2

Background

Transforming growth factor beta 2 ( TGFB2) is also known as TGF-β2, G-TSF, TGFB. is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The TGFB2 protein helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and the self-destruction of cells (apoptosis). The TGFB2 protein can inhibit the T cell growth by IL-2-dependent. and can inhibit immune surveillance during tumor development, the protein promoting tumor growth with an autocrine manner. TGF-β2 can affect the viability of killer cells and reduce the expression of IL-2, IL-6, IL-10, IFN-γ and other cytokines.TGFB2 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Trabedersen AP 2/09-DS; AP-12009; OT-201; AP-2/09; AP-2/09-DS; OT-101 Phase 3 Clinical Isarna Therapeutics Gmbh Solid tumours; Coronavirus Disease 2019 (COVID-19); Glioblastoma; Pancreatic Neoplasms; Mesothelioma; Astrocytoma; Colorectal Neoplasms; Diffuse Intrinsic Pontine Glioma; Carcinoma, Pancreatic Ductal; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma Details
Bintrafusp alfa M-7824; GSK-4045154; MSB-0011359C Phase 3 Clinical Merck Serono Brain metastases; Cholangiocarcinoma; Breast Neoplasms; Microsatellite Instability; Vulvar Neoplasms; Sarcoma; Nasopharyngeal Carcinoma; Prostatic Neoplasms; Colorectal Neoplasms; Thymus Neoplasms; Oropharyngeal Neoplasms; Gallbladder Neoplasms; Lung Neoplasms; Prostatic Neoplasms, Castration-Resistant; Lymphoma; Penile Neoplasms; Thymoma; Urogenital Neoplasms; Metastatic breast cancer; Carcinoma, Small Cell; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Melanoma; Neoplasm Metastasis; Sarcoma, Kaposi; Neoplasms, Germ Cell and Embryonal; Stomach Neoplasms; Solid tumours; Hematologic Neoplasms; Head and Neck Neoplasms; Intestinal Neoplasms; Skin Melanoma; Squamous Cell Carcinoma of Head and Neck; Rectal Neoplasms; Vaginal Neoplasms; Carcinoma; Carcinoma, Renal Cell; Esthesioneuroblastoma, Olfactory; Anus Neoplasms; Biliary Tract Neoplasms; Neoplasms; Triple Negative Breast Neoplasms; Colonic Neoplasms; Pancreatic Neoplasms; Nose Neoplasms; Ganglioglioma; Papillomavirus Infections; Carcinoma, Trans Details
Nisevokitug NIS-793 Phase 3 Clinical Xoma Corp Kidney Neoplasms; Polycythemia Vera; Pancreatic Neoplasms; Myelodysplastic Syndromes; Breast Neoplasms; Colorectal Neoplasms; Primary Myelofibrosis; Carcinoma, Pancreatic Ductal; Lung Neoplasms; Adenocarcinoma; Thrombocythemia, Essential; Carcinoma, Hepatocellular Details
ISTH-0036 ISTH-0036 Phase 2 Clinical Isarna Therapeutics Gmbh Glaucoma, Open-Angle; Diabetic macular oedema; Wet Macular Degeneration Details
TU-2218 TU-2218; NCE401; NCE-401 Phase 2 Clinical TiumBio Co Ltd Solid tumours; Idiopathic Pulmonary Fibrosis Details
LP-008 LP-008 Phase 1 Clinical Lepu Biopharma Co Ltd Solid tumours Details

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