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Your Position: Home > CD74

CD74

Brief Information

Name:HLA-DR antigens-associated invariant chain
Target Synonym:CLIP,CD74,Ia antigen-associated invariant chain,CD74 Molecule,CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex, Class II Antigen-Associated),CD74 Molecule, Major Histocompatibility Complex, Class II Invariant Chain,HLA-DR Antigens-A
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CD4-H5256 Human Human CD74 / DHLAG Protein, Fc Tag (MALS verified)
CD4-H5256-structure
CD4-H5256-sds
CD4-H524c Human Human CD74 / DHLAG Protein, His Tag
CD4-H524c-structure
CD4-H524c-sds

Part of Bioactivity data

CD4-H5256-MALS-HPLC
Human CD74, Fc Tag (Cat. No. ) MALS images

The purity of Human CD74, Fc Tag (Cat. No. CD4-H5256) was more than 85% and the molecular weight of this protein is around 320-340 kDa verified by SEC-MALS.

Report
  • Background
    Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.
  • Clinical and Translational Updates
      

  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Synonym Name

CD74,DHLAG,HLADG,II,Ia-GAMMA,p33,CLIP,INVG34

Background

Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Influenza A M1 vaccine (Pascal Biosciences) Phase 1 Clinical Pascal Biosciences Influenza A virus infections Details
Anti-CD 74 antibody drug conjugates(Sutro Biopharma) STRO-001 Phase 1 Clinical Sutro Biopharma Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Multiple Myeloma; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Lymphoma; Lymphoma, Non-Hodgkin Details
Milatuzumab hLL1; hCD74; IMMU-115 Phase 2 Clinical Immunomedics Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lupus Erythematosus, Discoid; Leukemia, Lymphoid; Plasmacytoma; Graft vs Host Disease; Lupus Erythematosus, Cutaneous; Myelodysplastic Syndromes; Multiple Myeloma; Lupus Nephritis; Lupus Erythematosus, Systemic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lupus Vasculitis, Central Nervous System; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details

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