CD74

CD74 Molecule Information

Name：HLA-DR antigens-associated invariant chain
Target Synonym：HLA-DR antigens-associated invariant chain?Ia antigen-associated invariant chain?Ii?CD74?HLA class II histocompatibility antigen gamma chain?p33?CD_antigen=CD74?DHLAG

Number of Launched Drugs：0
Number of Drugs in Clinical Trials：7
Lastest Research Phase：Phase ?

CD74 Protein Product ListCompare or Buy

Cat. No.	Species	Product Description	Structure	Purity	Feature
CD4-H524c	Human	human CD74 / DHLAG Protein

CD74 Molecule Synonym Name

CD74,DHLAG,HLADG,II,Ia-GAMMA,p33,CLIP,INVG34

CD74 Molecule Background

Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.

CD74 References

CD74 Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
SGN-15	BMS-182248; BMS-182248-01; BR96-DOX; SGN-15; hBR96	Phase Ⅱ	Bristol-Myers Squibb, Seattle Genetics	Non small cell lung cancer (NSCLC), Prostate cancer, Breast cancer, Colorectal cancer, Ovarian cancer	Details
Milatuzumab	hCD74; hLL1; IMMU-115,HCD-74	Phase Ⅱ	Immunomedics	Chronic lymphocytic leukemia (CLL), Graft versus host disease, Multiple myeloma (MM), Systemic lupus erythematosus, Non-Hodgkin's lymphoma (NHL)	Details
Monoclonal antibody LYM-1-I-131		Phase Ⅱ	Northwestern University, Peregrine, Schering Pharma	Non-Hodgkin's lymphoma (NHL)	Details
Apolizumab		Phase Ⅱ	PDL BioPharma	Solid tumours, Non-Hodgkin's lymphoma (NHL)	Details
Milatuzumab doxorubicin	CD-74-DOX; hCD74-DOX; hLL1-DOX; IMMU-110	Phase Ⅱ	Immunomedics	Chronic lymphocytic leukemia (CLL), Multiple myeloma (MM), Non-Hodgkin's lymphoma (NHL)	Details
IMMU-114	IMMU-114; hL243	Phase Ⅰ	Immunomedics	Chronic lymphocytic leukemia (CLL), Non-Hodgkin's lymphoma (NHL)	Details
Anti-CD 74 antibody drug conjugates(Sutro Biopharma)	STRO-001	Phase Ⅰ	Sutro Biopharma	Multiple myeloma (MM), Lymphoma	Details