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CD74 Molecule Information

Name:HLA-DR antigens-associated invariant chain
Target Synonym:HLA-DR antigens-associated invariant chain;Ia antigen-associated invariant chain;Ii;CD74;HLA class II histocompatibility antigen gamma chain;p33;CD_antigen=CD74;DHLAG
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
CD4-H5224 Human Human CD74 / DHLAG Protein, His Tag
CD4-H524c Human Human CD74 / DHLAG Protein, His Tag

CD74 Molecule Synonym Name


CD74 Molecule Background

Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.

CD74 References

CD74 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ANG-1007 (AngioChem) ANG-3201; ANG-1007; ANG-1009; ANG-1011; ANG-2002; ANG-2004; ANG-3101; ANG-3202; ANG-4043 Preclinical AngioChem Cancer Details
Milatuzumab hCD74; hLL1; IMMU-115,HCD-74 Phase Ⅱ Immunomedics Chronic lymphocytic leukemia (CLL), Graft versus host disease, Multiple myeloma (MM), Systemic lupus erythematosus, Non-Hodgkin's lymphoma (NHL) Details
Monoclonal antibody LYM-1-I-131 Phase Ⅱ Northwestern University, Peregrine, Schering Pharma Non-Hodgkin's lymphoma (NHL) Details
Apolizumab Phase Ⅱ PDL BioPharma Solid tumours, Non-Hodgkin's lymphoma (NHL) Details
Milatuzumab doxorubicin CD-74-DOX; hCD74-DOX; hLL1-DOX; IMMU-110 Phase Ⅱ Immunomedics Chronic lymphocytic leukemia (CLL), Multiple myeloma (MM), Non-Hodgkin's lymphoma (NHL) Details
IMMU-114 IMMU-114; hL243 Phase Ⅰ Immunomedics Chronic lymphocytic leukemia (CLL), Non-Hodgkin's lymphoma (NHL) Details
Anti-CD 74 antibody drug conjugates(Sutro Biopharma) STRO-001 Phase Ⅰ Sutro Biopharma Multiple myeloma (MM), Lymphoma Details

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