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CD79B

CD79B Molecule Information

Name:B-cell antigen receptor complex-associated protein beta chain
Target Synonym:B29,Immunoglobulin-associated B29 protein,Ig-beta,B-cell-specific glycoprotein B29,CD79B,CD79b Molecule,CD79b Molecule, Immunoglobulin-Associated Beta,IGB,CD79B Antigen (Immunoglobulin-Associated Beta),CD79b Antigen,AGM6,B-Cell Antigen Receptor Complex-As
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

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CD79B Part of Bioactivity data

CDB-H52H3-MALS-HPLC
Human CD79B, His Tag (Cat. No. ) MALS images

The purity of Human CD79B, His Tag (Cat. No. CDB-H52H3) was more than 85% and the molecular weight of this protein is around 26-36 kDa verified by SEC-MALS.

  • Background
    B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.
  • References
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

    CDB-H82E3-MALS-HPLC
    Biotinylated Human CD79B, His,Avitag (Cat. No. ) MALS images

    The purity of Biotinylated Human CD79B, His,Avitag (Cat. No. CDB-H82E3) was more than 90% and the molecular weight of this protein is around 27-37 kDa verified by SEC-MALS.

CD79B Molecule Synonym Name

CD79b,B29,IGB,Ig-beta

CD79B Molecule Background

B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.

CD79B References

CD79B Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Polatuzumab vedotin RG-7596; FCU-2711; DCDS-4501A; RO-5541077; RO-5541077-000 Approved Seattle Genetics, Genentech Inc Polivy Japan Lymphoma, Large B-Cell, Diffuse s:23:"F. Hoffmann-La Roche Ag"; 2019-06-10 Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Follicular; Lymphoma, Non-Hodgkin Details

CD79B Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
PRV-3279 MGD-010; PRV-3279; CD32BxCD-79B Phase 2 Clinical Macrogenics Autoimmune Diseases; Lupus Erythematosus, Systemic Details
Iladatuzumab vedotin DCDS-0780A; RO-7032005 Phase 1 Clinical F. Hoffmann-La Roche Ltd Lymphoma, Non-Hodgkin Details

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