CD79B
CD79B Molecule Information
Name:B-cell antigen receptor complex-associated protein beta chain
Target Synonym:Ig-beta;CD79b;B29;IGB;Immunoglobulin-associated B29 protein;B-cell-specific glycoprotein B29;CD79B
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved
CD79B Molecule Synonym Name
CD79b,B29,IGB,Ig-beta
CD79B Molecule Background
B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.
CD79B References
CD79B Public Drug Information
Name |
Research Code |
Research Phase |
Company |
First Brand Name |
First Approved Country |
First Indication |
First Approved Company |
First Approved Date |
Indications |
Clinical Trials |
Polatuzumab vedotin |
DCDS-4501A; FCU-2711; RG-7596; RO-5541077; RO-5541077-000 |
Approved |
Genentech, Seattle Genetics, Chugai |
POLIVY |
fda |
Diffuse large B cell lymphoma |
GENENTECH |
2019-06-10 |
Diffuse large B cell lymphoma |
Details
|
CD79B Clinical Drug Information
Name |
Research Code |
Research Phase |
Company |
Indications |
Clinical Trials |
Iladatuzumab vedotin |
DCDS-0780A; RO-7032005 |
Phase Ⅰ |
Roche |
Non-Hodgkin's lymphoma (NHL) |
Details
|
PRV-3279 |
PRV-3279; MGD-010; CD32BxCD-79B |
Phase Ⅱ |
MacroGenics, Provention Bio |
Autoimmune diseases, Systemic lupus erythematosus |
Details
|