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Laminin 511 E8

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Cat. No. Species Product Description Structure Purity Feature
LA8-H5283 Human Human Laminin 511 E8 Protein, premium grade
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Part of Bioactivity data

LA8-H5283-BLI
 Laminin 511 E8 BLI

Loaded Human Laminin 511 E8 Protein, Fc Tag, premium grade (Cat. No. LA8-H5283) on Protein A Biosensor, can bind Human ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52Wc) with an affinity constant of 2.92 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

LA8-H5283-BLI
 Laminin 511 E8 BLI

Loaded Human ITGA6&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52W7) on HIS1K Biosensor, can bind Human Laminin 511 E8 Protein, Fc Tag, premium grade (Cat. No. LA8-H5283)with an affinity constant of 1.65 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

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Synonym Name

Laminin 511 E8, LN-511-E8, Laminin-511 E8

Background

Laminin 511 E8 is a truncated laminin 511, which is one of the ECM proteins. laminin E8s serve as functionally minimal forms that retain the full capability for binding to integrins. Laminin 511-E8 consists of the C-terminal end of the alpha 5, beta 1, and gamma 1 chains. The laminin-511 heterotrimer (α5β1γ1) is one of the isoforms to be identified and a potent adhesive and pro-migratory substrate for a variety of normal and tumor cell lines in vitro. Previous studies indicated that laminin-511 contributes to tumor dissemination and metastasis in advanced breast carcinomas and other tumor types. Additionally, latest research uncovered that Laminin 511 might be a target antigen and involved in autoimmune pancreatitis.

Clinical and Translational Updates

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