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RAGE Molecule Information

Name:Advanced glycosylation end product-specific receptor
Target Synonym:RAGE;AGER;Advanced glycosylation end product-specific receptor;Receptor for advanced glycosylation end products
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Phase ?

RAGE Molecule Synonym Name


RAGE Molecule Background

Advanced glycosylation end product-specific receptor (AGER) is also known as RAGE, and is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. AGER is highly expressed in endothelial cells. AGER mediates interactions of advanced glycosylation end products (AGE), and also accumulates in vascular tissue in aging and at an accelerated rate in diabetes, as well as acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGER / RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.

RAGE References

RAGE Related Molecule

RAGE Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Azeliragon TTP-488; PF-04494700; PF-4494700,PF04494700,TTP488 Phase Ⅲ vTv Therapeutics Alzheimer's disease (AD) Details
Tenilsetam CAS-997 Phase Not Specified Sanofi Dementia Details
TRC-041266 TRC-041266 Phase Ⅲ Torrent Pharmaceuticals Chronic heart failure Details
TRC-4186 TX-41XX; TRC-4186 Phase Ⅱ Torrent Pharmaceuticals Diabetic complications, Heart failure Details
Alagebrium chloride ALT-711 Phase Ⅲ Synvista Therapeutics Cardiovascular disorders, Erectile dysfunction (ED), Hypertension, Heart failure Details
TTP-4000 TTP-4000 Phase Ⅰ vTv Therapeutics Alzheimer's disease (AD) Details

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