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ACRO Quality

Part of Bioactivity data

TSPAN8 MALS images

The purity of Mouse TSPAN8 Protein, His Tag (Cat. No. TS8-M5249) is more than 90% and the molecular weight of this protein is around 13-18 kDa verified by SEC-MALS.

TSPAN8 MALS images

The purity of Canine TSPAN8, His Tag (Cat. No. TS8-C5248) is more than 95% and the molecular weight of this protein is around 13-18 kDa verified by SEC-MALS.

Synonym Name

CO-029,tetraspanin 8,TM4SF3,TM4SF3tspan-8,Transmembrane 4 superfamily member 3tetraspanin-8,TSPAN8,Tspan-8,Tumor-associated antigen CO-029


Tspan8 is 1 of the 33 mammalian members of the tetraspanin family, composed of transmembrane proteins that organize laterally, together or with other membrane partners such as integrins, to form ‘tetraspanin webs’. These platforms signal within cells to regulate many cellular processes: adhesion, migration, invasion or survival Tspan8 has been implicated in many types of cancer.Overexpression was reported in glioma and colorectal, esophageal, hepatic, gastric and pancreatic carcinoma. Tspan8 exerts a pro-invasive function by controlling cell–cell and cell–matrix interactions through its association with membrane partners such as α6β4 integrin-protein kinase C (PKC)-activated, E-cadherin, EpCAM, claudin-7 and CD44. Moreover, Tspan8 may be a promising new therapeutic target, as Tspan8-specific antibodies were shown to reduce cell motility, block tumor angiogenesis in vivo.

Clinical and Translational Updates

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