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Your Position: Home > Klotho

Klotho

ACRO Quality

Synonym Name

KL, Klotho, Klotho peptide

Background

The Klotho protein, also known as α-Klotho, is a multifunctional protein that regulates the metabolism of phosphate, calcium, and vitamin D. Klotho may also  function as a hormone. Three Klotho protein types with potentially different functions have been identified: a full-length transmembrane Klotho, a truncated soluble Klotho, and a secreted Klotho. Recent evidence suggests that Klotho suppresses the insulin and Wnt signaling pathways, inhibits oxidative stress, and regulates phosphatase and calcium absorption.

Clinical and Translational Updates

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