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B7-2

B7-2 Product List

Cat. No. Species Product Description Structure Purity Feature
CD6-C5254 Cynomolgus Cynomolgus / Rhesus macaque B7-2 / CD86 Protein, Fc Tag
CD6-C5254-structure
CD6-C5254-sds
CD6-C5254-elisa_1
CD6-C52H5 Cynomolgus Cynomolgus / Rhesus macaque B7-2 / CD86 Protein (HPLC-verified)
CD6-C52H5-structure
CD6-C52H5-sds
CD6-C52H5-hplc
CD6-H5257 Human Human B7-2 / CD86 Protein, Fc Tag
CD6-H5257-structure
CD6-H5257-sds
CD6-H5257-elisa_1
CD6-H5223 Human Human B7-2 / CD86 Protein
CD6-H5223-structure
CD6-H5223-sds
CD6-H5223-elisa_1
CD6-H82E2 Human Biotinylated Human B7-2 / CD86 Protein, Avi Tag (Avitag™)
CD6-H82E2-structure
CD6-H82E2-sds
CD6-H82E2-elisa_1
CD6-H82F5 Human Biotinylated Human B7-2 / CD86 Protein, Fc Tag, Avi Tag (Avitag™)
CD6-H82F5-structure
CD6-H82F5-sds
CD6-H82F5-elisa_1
CD6-M5251 Mouse Mouse B7-2 / CD86 Protein, Fc Tag
CD6-M5251-structure
CD6-M5251-sds
CD6-M5251-elisa_1
CD6-M52H0 Mouse Mouse B7-2 / CD86 Protein
CD6-M52H0-structure
CD6-M52H0-sds
CD6-M52H0-elisa_1

B7-2 Molecule Synonym Name

CD86,B7-2,B70,CD28LG2,LAB72,MGC34413

B7-2 Molecule Background

Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon ¦Ã. CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. Recent study has revealed that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival. Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-¦ÊB-signaling pathway in macrophages. CD86 thus is regarded as a promising candidate for immune therapy. CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.

B7-2 References

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