Login Register
icon_bulk_orderBulk order Acrobiosystems for English
0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > CCL20

CCL20

Brief Information

Name:C-C motif chemokine 20
Target Synonym:Chemokine CCL20,Exodus-1,ST38,Chemokine (C-C Motif) Ligand 20,CCL20,LARC,C-C motif chemokine 20,SCYA20,MIP-3-alpha,C-C Motif Chemokine Ligand 20,Small Inducible Cytokine Subfamily A (Cys-Cys), Member 20,Liver And Activation-Regulated Chemokine,Macrophage Inflammatory Protein 3 Alpha,MIP-3a,CKb4,Small-Inducible Cytokine A20,CC Chemokine LARC,MIP3A,Beta Chemokine Exodus-1,Beta-Chemokine Exodus-1,Exodus
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Discontinued

Product ListCompare or Buy

By Product Status:
By Product Category:
By Species:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
CC0-M82E5 Mouse Biotinylated Mouse CCL20 / MIP-3 alpha Protein, His,Avitag™
CC0-M82E5-structure

Synonym Name

C-C motif chemokine 20,Beta-chemokine exodus-1,CC chemokine LARC,Liver and activation-regulated chemokine,Macrophage inflammatory protein 3 alpha,MIP-3-alpha,Small-inducible cytokine A20,CCL20

Background

C-C motif chemokine 20(CCL20) acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes . Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes.

Clinical and Translational Updates

This web search service is supported by Google Inc.

totop
Call us
Call us
North America: +1 800-810-0816 (Toll Free)
Asia & Pacific: +86 400-682-2521
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA

Leave a message