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CCL20

Brief Information

Name:C-C motif chemokine 20
Target Synonym:Chemokine CCL20,Exodus-1,ST38,Chemokine (C-C Motif) Ligand 20,CCL20,LARC,C-C motif chemokine 20,SCYA20,MIP-3-alpha,C-C Motif Chemokine Ligand 20,Small Inducible Cytokine Subfamily A (Cys-Cys), Member 20,Liver And Activation-Regulated Chemokine,Macrophage Inflammatory Protein 3 Alpha,MIP-3a,CKb4,Small-Inducible Cytokine A20,CC Chemokine LARC,MIP3A,Beta Chemokine Exodus-1,Beta-Chemokine Exodus-1,Exodus
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Discontinued

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Cat. No. Species Product Description Structure Purity Feature
CC0-H51H3 Human Human CCL20 Protein, His Tag (HPLC verified)
CC0-H51H3-structure
CC0-H51H3-sds
CC0-H51H3-hplc
ACRO Quality

Part of Bioactivity data

CC0-H51H3-ELISA
 CCL20 ELISA

Immobilized Human CCL20 Protein, His Tag (Cat. No. CC0-H51H3) at 5 μg/mL (100 μL/well) can bind Human CCR6 Full Length Protein (VLP) (Cat. No. CC6-H52P3) with a linear range of 0.078-2.5 μg/mL (QC tested).

Synonym Name

C-C motif chemokine 20,Beta-chemokine exodus-1,CC chemokine LARC,Liver and activation-regulated chemokine,Macrophage inflammatory protein 3 alpha,MIP-3-alpha,Small-inducible cytokine A20,CCL20

Background

C-C motif chemokine 20(CCL20) acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes . Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes.

Clinical and Translational Updates

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