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Your Position: Home > Sortilin

Sortilin

Brief Information

Name:Sortilin
Target Synonym:100 kDa NT receptor,NT3,Glycoprotein 95,LDLCQ6,NTR3,Gp95,Sortilin 1,Neurotensin receptor 3
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

SON-H82E9-MALS-HPLC
Biotinylated Human Sortilin / SORT1, His,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human Sortilin / SORT1, His,Avitag (Cat. No. SON-H82E9) is more than 85% and the molecular weight of this protein is around 80-104 kDa verified by SEC-MALS.

  • Background
    The Sortilin is a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

    SON-H52H5-MALS-HPLC
    Human Sortilin / SORT1, His Tag (Cat. No. ) MALS images

    The purity of Human Sortilin / SORT1, His Tag (Cat. No. SON-H52H5) is more than 85% and the molecular weight of this protein is around 78-105 kDa verified by SEC-MALS.

Synonym Name

Sortilin,SORT1,100 kDa NT receptor,Glycoprotein 95,Gp95,Gp95LDLCQ6,Neurotensin receptor 3,NT3NTR3,Ntr3,sortilin 1,

Background

The Sortilin is a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Latozinemab GSK-4527223; AL-001 Phase 3 Clinical Alector, Glaxosmithkline Plc Alzheimer Disease; Frontotemporal Dementia; Amyotrophic Lateral Sclerosis Details

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