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Your Position: Home > CD79A

CD79A

Brief Information

Name:B-cell antigen receptor complex-associated protein alpha chain
Target Synonym:Ig-alpha,MB-1 membrane glycoprotein,Membrane-bound immunoglobulin-associated protein,Surface IgM-associated protein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CDA-C52H3 Cynomolgus Cynomolgus CD79A Protein, His Tag
CDA-C52H3-structure
CDA-C52H3-sds
CDA-H52H8 Human Human CD79A Protein, His Tag
CDA-H52H8-structure
CDA-H52H8-sds
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Synonym Name

CD79A, CD79a, B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha, MB-1 membrane glycoprotein, Membrane-bound immunoglobulin-associated protein,  Surface IgM-associated p

Background

B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain(CD79a), also known as CD79α, IgM-α, Ig-α and mb-1, which is a signaling component of the preB cell receptor (preBCR). Covalently linked CD79a and CD79b heterodimer constitutes the B cell antigen receptor (BCR) with membrane immunoglobulin (mIg) in a non-covalent association. CD79a is required in cooperation with CD79b for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR), leading to internalization of the complex, trafficking to late endosomes and antigen presentation. CD79a is also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
bbT-369 bbT-369 Phase 2 Clinical Bluebird Bio Inc Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin Details

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