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Your Position: Home > C1q R1

C1q R1

Brief Information

Name:Complement component C1q receptor
Target Synonym:C1q/MBL/SPA receptor,C1qR,C1qRp,C1qR(p),CDw93,Complement component 1 q subcomponent receptor 1,Matrix-remodeling-associated protein 4
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
C11-H82E9 Human Biotinylated Human C1q R1 / CD93 Protein, His,Avitag™
C11-H82E9-structure
C11-H82E9-sds
C11-H5228 Human Human C1q R1 / CD93 Protein, His Tag (MALS verified)
C11-H5228-structure
C11-H5228-sds
ACRO Quality

Part of Bioactivity data

C11-H5228-SPR
C1q R1 SPR

Human IGFBP-7, His Tag (Cat. No. IG7-H5240) immobilized on CM5 Chip can bind Human C1q R1, His Tag (Cat. No. C11-H5228) with an affinity constant of 16.7 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
C11-H82E9-BLI
C1q R1 BLI

Loaded Biotinylated Human C1q R1, His,Avitag (Cat. No. C11-H82E9) on SA Biosensor, can bind Human IGFBP-7, His Tag (Cat. No. IG7-H5240) with an affinity constant of 0.93 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

CD93,CDw93,C1QR1,MXRA4,C1qR,C1qR(P),C1qRP,ECSM3

Background

CD antigen CD93 is also known as Complement component C1q receptor (C1QR1). which belongs to the Group XIV C-Type lectin family, a group containing two other members, endosialin (CD248) and thrombomodulin. CD93 contains one C-type lectin domain and five EGF-like domains. CD93 is highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. CD93 is receptor for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). CD93 may mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens and may play a role in intercellular adhesion.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
DCBY-02 DCBY-02 Phase 1 Clinical DynamiCure Biotechnology Ltd Solid tumours Details

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