Norovirus is one of the leading causes of non-bacterial acute gastroenteritis which affects millions of people all over the world. Norovirus has a variety of genotypes with the GII.4 dominating the recent norovirus outbreaks. Besides GII.4, GI.1 is also important for research on Norovirus as it is the original genotype of Norovirus. The capsid protein VP1 is the target for vaccine and antibody development and an Anti-VP1 (NoV)-antibody-5I2 was found to be able to interact with the VP1, serving as a receptor for it.
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