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Your Position: Home > Alpha-fetoprotein


Brief Information

Target Synonym:Alpha-Fetoglobulin,AFP,Alpha-fetoprotein,Alpha Fetoprotein,Alpha-1-Fetoprotein,HPAFP,AFPD,FETA,alpha-Fetoproteins
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
ALN-H52H9 Human Human Alpha-fetoprotein, His Tag
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Alpha-fetoprotein(AFP) is the first tumor marker with clinical application value found by human. AFP has an ability to induce the immune escapes through inhibiting the function of dendritic cells, natural killer cells, and T lymphocytes. By in vitro modification, the immunogenicity and immune response of AFP could be enhanced. AFP-modified immune cell vaccine or peptide vaccine has displayed the specific antitumor immunity against AFP-positive tumor cells and laid a better foundation for the immunotherapy of liver cancer. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ET1402L1-ARTEMIS T cells Phase 1 Clinical Aeon Therapeutics (Beijing) Co Ltd Liver Neoplasms; Carcinoma, Hepatocellular Details
JWATM-203 JWATM-203; JWATM203 Phase 2 Clinical Suzhou Yaomingjunuo Biotechnology Co Ltd Carcinoma, Hepatocellular Details
Alpha fetoprotein targeted T-cell therapy (Adaptimmune) AFP TCR (ADP-A2AFP); ADP-A2AFP; AFP TCR; AFPc332T Phase 1 Clinical Adaptimmune Llc Liver Neoplasms Details
ET1402L1-CART AFP/ET-1402; ET1402; ET-1402; AFP-CAR; ET-140202 Phase 1 Clinical Eureka Therapeutics Inc Liver Neoplasms; Carcinoma, Hepatocellular Details
SynOV1.1 Phase 2 Clinical Beijing Syngentech Co Ltd Solid tumours; Carcinoma, Hepatocellular Details
TAEST-1901 TAEST-1901 Phase 1 Clinical Xiangxue Life Science Technology (Guangdong) Co Ltd Liver Neoplasms; Neoplasms Details
CPU-118 CPU-118 Phase 1 Clinical China Pharmaceutical University, Nanjing Qinling Pharmaceutical Technology Co Ltd Liver Neoplasms; Solid tumours; Neoplasms Details

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