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Your Position: Home > Endoglin

Endoglin

Brief Information

Name:Endoglin
Target Synonym:CD105 Antigen,CD105,END,ENG,Osler-Rendu-Weber Syndrome 1,HHT1,ORW1,Endoglin
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
ENN-H52H9 Human Human Endoglin / CD105 Protein, His Tag
ENN-H52H9-structure
ENN-H52H9-sds
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Synonym Name

Endoglin,CD105,ENG,END

Background

Endoglin (ENG), endothelial glycoprotein, also known as CD105, is a coreceptor of the transforming growth factor-β (TGFβ) family signaling complex, which is highly expressed on endothelial cells and plays a key role in angiogenesis. It regulates the responses associated with binding to transforming growth factor β1 egg (Activin-A), bone morphogenetic protein 2 (BMP-2), and bone morphogenetic protein 7 (BMP-7). Endoglin may be involved in autosomal dominant disease, such as hereditary hemorrhagic telangiectasia 1 (HHT1). Circulating soluble ENG is also elevated in pulmonary arterial hypertension(PAH) and is proposed to be a biomarker for the prognosis of group I PAH patients.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Carotuximab DE-122; TRC-105; Chimeric Antibody TRC-105; NSC#754227 Phase 2 Clinical Roswell Park Cancer Institute Brain Neoplasms; Macular Degeneration; Neoplasm Metastasis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Glioma; Adenoma, Liver Cell; Trophoblastic Tumor, Placental Site; Choriocarcinoma; Fallopian Tube Neoplasms; Ureteral Neoplasms; Astrocytoma; Gliosarcoma; Peritoneal Neoplasms; Prostatic Neoplasms; Ovarian Neoplasms; Breast Neoplasms; Sarcoma; Prostatic Neoplasms, Castration-Resistant; Liver Neoplasms, Experimental; Oligodendroglioma; Gestational Trophoblastic Disease; Carcinoma, Transitional Cell; Neoplasms; Glioblastoma; Trophoblastic Neoplasms; Carcinoma, Renal Cell; Hemangiosarcoma; Liver Neoplasms; Solid tumours Details

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