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Your Position: Home > GSK-3beta

GSK-3beta

Brief Information

Name:Glycogen synthase kinase-3 beta
Target Synonym:EC 2.7.11,EC:2.7.11.26,EC:2.7.11.1,Serine/threonine-protein kinase GSK3B,Glycogen synthase kinase-3 beta,GSK3B,Glycogen Synthase Kinase 3 Beta,GSK-3 Beta,GSK3beta Isoform,EC 2.7.11.26,EC 2.7.11.1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
GSB-H5545 Human Human GSK-3beta / GSK-3β Protein, His Tag (active enzyme, HPLC verified)
GSB-H5545-structure
GSB-H5545-sds
GSB-H5545-hplc
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Synonym Name

GSK3B,Glycogen synthase kinase-3 beta

Background

Glycogen synthase kinase-3 (GSK-3) is a pivotal molecule in the development of Alzheimer's disease (AD). GSK-3beta is involved in the formation of paired helical filament (PHF)-tau, which is an integral component of the neurofibrillary tangle (NFT) deposits that disrupt neuronal function, and a marker of neurodegeneration in AD.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ruboxistaurin Mesilate Hydrate LY-333531; REC 3599; SM 030 Phase 2 Clinical Eli Lilly And Company Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Hyperpigmentation; Heart Failure; Diabetic Neuropathies; Diabetic macular oedema; Diabetic Nephropathies; Diabetic Retinopathy; Diabetes Mellitus Details
Elraglusib 9-ING-41 Phase 2 Clinical Northwest University, Actuate Therapeutics Inc, University Of Illinois At Chicago Sarcoma; Adenocarcinoma; Meningioma; Neoplasm Metastasis; Lymphoma; Lymphoma, Non-Hodgkin; Lung Neoplasms; Glioma; Primary Myelofibrosis; Bone Neoplasms; Colorectal Neoplasms; Diffuse Intrinsic Pontine Glioma; Neuroblastoma; Breast Neoplasms; Brain Neoplasms; Leiomyosarcoma; Sarcoma, Ewing; Osteosarcoma; Carcinoma, Adenoid Cystic; Liposarcoma; Sarcoma, Synovial; Salivary Gland Neoplasms; Neoplasms; Leukemia-Lymphoma, Adult T-Cell; Pancreatic Neoplasms; Dermatofibrosarcoma; Hemangiosarcoma; Bone metastases; Kidney Neoplasms; Rhabdomyosarcoma Details
Tideglusib NP-12; AMO-02; NP-031112 Phase 3 Clinical Noscira Sa Autism Spectrum Disorder; Myotonic Dystrophy; Alzheimer Disease; Amyotrophic Lateral Sclerosis Details

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