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Your Position: Home > Laminin 221 E8

Laminin 221 E8

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Cat. No. Species Product Description Structure Purity Feature
LA2-H5269 Human Human Laminin 221 E8 Protein, Fc Tag, premium grade
LA2-H5269-sds
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Part of Bioactivity data

LA2-H5269-SPR
Laminin 221 E8 SPR

Human ITGA7X2B&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52W8) immobilized on CM5 Chip can bind Human Laminin 221 E8 Protein, Fc Tag, premium grade (Cat. No. LA2-H5269) with an affinity constant of 49.8 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
LA2-H5269-MALS-HPLC
Laminin 221 E8 MALS images

The purity of Human Laminin 221 E8 Protein, Fc Tag, premium grade (Cat. No. LA2-H5269) is more than 85% and the molecular weight of this protein is around 205-255 kDa verified by SEC-MALS.

Synonym Name

Laminin 221 E8

Background

Laminin-221 (LM221) takes multiple roles as a scaffold to store cells, growth factors and cytokines and is the most likely expressed cardiac laminin that maintains physiological activities of myocytes. Laminin 221-E8 consists of the C-terminal end of the alpha 2, beta 2, and gamma 1 chains. Previous study has confirmed that the laminin-221 heterotrimer (α2β2γ1) could bind integrin α7X1 and α7X2. Latest research indicated that the administration of LM221 enhanced accumulation of smooth muscle actin (SMA) and isolectin B4 (ILB4) double-positive cells to the damaged area and contributed to the improvement of cardiac function.

Clinical and Translational Updates

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