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Complement C3

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Part of Bioactivity data

CO3-H82E8-MALS-HPLC
Biotinylated Human Complement C3, His,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human Complement C3, His,Avitag (Cat. No. CO3-H82E8) is more than 85% and the molecular weight of this protein is around 165-200 kDa verified by SEC-MALS.

  • Background
    C3 is the major complement component serum. It is mainly synthesized by macrophages and liver. C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. It is cleaved into two fragments, C3a and C3b. C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

    CO3-C52H5-MALS-HPLC
    Cynomolgus Complement C3, His Tag (Cat. No. ) MALS images

    The purity of Cynomolgus Complement component 3, His Tag (Cat. No. CO3-C52H5) is more than 85% and the molecular weight of this protein is around 168-205 kDa verified by SEC-MALS.

Synonym Name

Complement C3,CPAMD1

Background

C3 is the major complement component serum. It is mainly synthesized by macrophages and liver. C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. It is cleaved into two fragments, C3a and C3b. C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Clinical and Translational Updates

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