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Brief Information

Name:Retinal guanylyl cyclase 1
Target Synonym:RETGC-1,CG-E,Guanylate cyclase 2D, retinal,Rod outer segment membrane guanylate cyclase (ROS-GC),CORD6,GUC1A4,GUC2D,RETGC,RETGC1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
GUD-H82E6 Human Biotinylated Human GUCY2D / Retinal guanylyl cyclase 1 Protein, His,Avitag™
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Synonym Name

GUCY2D,Retinal guanylyl cyclase 1,RETGC-1,CORD6,GUC1A4,GUC2D,ROS-GC


GUCY2D also known as CORD6, GUC1A4, GUC2D ROS-GC and RETGC-1, belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ATSN-101 SAR-439483; ATSN-101 Phase 2 Clinical University Of Florida Leber Congenital Amaurosis Details

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