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Synonym Name

DA transporter,DATDAT1,Solute carrier family 6 member 3,sodium-dependent dopamine transporter


The dopamine transporter (DAT) is a 70-80 kDa member of the Na+-neurotransmitter symporter family of transmembrane (TM) proteins coded by gene SLC6A3. DAT plays a crucial role in the synaptic clearance of dopamine (DA). It terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. One molecule of DA is accompanied by two Na+ and one Cl- ion. Molecules such as amphetamine both competitively inhibit DA uptake, and induce DA release through the DAT, increasing the rewarding property of DA. Human DAT is a 620 amino acid (aa), 12 TM phosphoglycoprotein with an N- and C-terminal cytoplasmic domain. It exists as a disulfide-linked oligomer on the cell surface.

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