CLEC3B Protein - ACROBiosystems

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CLEC3B

Brief Information

Name:Tenascin
Target Synonym:Glioma-associated-extracellular matrix antigen,GMEM,Neuronectin,Hexabrachion,Tenascin-C,TN-C,GP 150-225,TNC,Tenascin C,Deafness, Autosomal Dominant 56,Hexabrachion (Tenascin),Myotendinous Antigen,Cytotactin,HXB,JI,TN,Hexabrachion (Tenascin C, Cytotactin),Tenascin-C Additional Domain 1,Tenascin-C Isoform 14/AD1/16,150-225,DFNA56,GP,Tenascin,MGC167029

Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

Synonym Name

CLEC3B,Tetranectin,TN,TNA

Background

C-type lectin domain family 3 member B (CLEC3B) is also known as Tetranectin, Plasminogen kringle 4-binding protein, is a secreted homotrimer. CLEC3B contains 1 C-type lectin domain and mainly found in plasma. Tetranectin / CLEC3B binds to plasminogen and to isolated kringle 4. CLEC3B may be involved in the packaging of molecules destined for exocytosis. Decreased plasma Tetranectin or increased Tetranectin in stroma of cancers correlates with cancer progression and adverse prognosis.

Clinical and Translational Updates

Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
F16 IL2 fusion protein (Philogen)	F-16-IL-2	Phase 2 Clinical	Philogen	Solid tumours; Carcinoma, Merkel Cell; Hemangiosarcoma; Breast Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung; Melanoma	Details