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Your Position: Home > Melanotransferrin

Melanotransferrin

Brief Information

Name:Melanotransferrin
Target Synonym:Melanoma-associated antigen p97,CD228,Antigen P97 (Melanoma Associated) Identified By Monoclonal Antibodies 133.2 And 96.5,MAP97,Membrane-Bound Transferrin-Like Protein,MGC4856,MTF1,FLJ38863,CD228 Antigen,MTf,MFI2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
MEN-H5223 Human Human Melanotransferrin / CD228 Protein, His Tag (MALS verified)
MEN-H5223-structure
MEN-H5223-sds
ACRO Quality

Part of Bioactivity data

MEN-H5223-ELISA
Melanotransferrin MALS images

The purity of Human Melanotransferrin, His Tag (Cat. No. MEN-H5223) is more than 95% and the molecular weight of this protein is around 38-48 kDa verified by SEC-MALS.

Synonym Name

Melanotransferrin,CD228,MFI2,MAP97,MELTF

Background

Melanotransferrin (MTF), also known as CD228, P97, MELTF and MFI2, is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. MTF expression is low in normal tissues but high in tumor and embryonic tissues. In melanoma MTF is associated with tumor metastasis and angiogenesis and upregulated in lung cancer tissue and cell lines. In the brain MTF is expressed in capillary endothelium but also in the reactive microglia associated with senile plaques in Alzheimer's disease (AD).

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SGN-CD228A SGN-CD228A Phase 1 Clinical Seattle Genetics Inc Skin Melanoma; Mesothelioma; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung Details
SGN-BB228 SGN-BB228 Phase 1 Clinical Seagen Inc Skin Melanoma; Pancreatic Neoplasms; Mesothelioma; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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