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Brief Information

Name:Adenosine A2a receptor
Target Synonym:Adenosine receptor A2a,ADORA2A,Adenosine A2a Receptor,ADORA2,Adenosine Receptor Subtype A2a,A2aR,RDC8,Receptor, Adenosine A2A
Number of Launched Drugs:45
Number of Drugs in Clinical Trials:21
Lastest Research Phase:Approved


Project Name Modality Therapeutic Area Indications Stage Right Available
A2aR/A2bR Antagonist Small molecule Oncology/Cancer Advanced solid tumor,Advanced hematological tumor IND Global  (except China)

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By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
ADA-H52H5 Human Human ADORA2A Protein, His Tag (Detergent, Inhibitor added)
ADA-H52P4 Human Human ADORA2A Full Length Protein (VLP)
ACRO Quality

Part of Bioactivity data


Anti-ADORA2A antibody-3F6-9G5 captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human ADORA2A Protein, His Tag (Cat. No. ADA-H52H5) with an affinity constant of 21.8 nM as determined in a SPR assay (in presence of DDM and CHS) (Biacore 8K) (Routinely tested).


Immobilized Human ADORA2A Full Length Protein-VLP (Cat. No. ADA-H52P4) at 5 μg/mL (100 μL/well) can bind Monoclonal Anti-Human ADORA2A antibody, Human IgG1 with a linear range of 0.3-5 ng/mL (QC tested).

Synonym Name

ADORA2A,adenosine A2a receptor,A2aR, ADORA2, RDC8


Adenosine Receptor Subtype A2a (ADORA2A) is a G-protein coupled adenosine receptor encoded by the ADORA2A gene. It is mainly involved in pathophysiological processes including neuroinflammation, synaptic plasticity in glutamatergic synapses and neurogenes

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Regadenoson Hydrate CVT-3146 Approved Astellas Pharma Inc Lexiscan, Rapiscan United States Contrast agents Astellas Pharma Inc 2008-04-10 Myocardial Ischemia; Rejection of lung transplantation; Cardiovascular contrast agents; Pneumonia; Coronary Artery Disease; Heart Diseases; Glioblastoma; Coronavirus Disease 2019 (COVID-19); Retinal Artery Occlusion; Oligodendroglioma; Contrast agents; Cardiovascular Diseases; Astrocytoma; Diagnostic agents; Glioma; Anemia, Sickle Cell Details
Caffeine/Ergotamine Tartrate Approved Novartis Pharma Ag Cafergot Mainland China Migraine Disorders Tianjin Medical University Pharmaceutical Factory 1948-11-26 Migraine Disorders Details
Oxtriphylline Approved Theocolin Canada null Asthma Details
Caffeine/Metamizole Sodium/Dihydroergotamine Mesylate Approved Cefaliv Migraine Disorders Details
Adenine Approved Leucon Japan Leukopenia Ohara Pharmaceutical Co Ltd Leukemia; Leukopenia Details
Istradefylline KW-6002 Approved Kyowa Hakko Kirin Co Ltd Nourianz, Nouriast Japan Parkinson Disease Kyowa Hakko Kirin Co Ltd 2013-03-25 Substance-Related Disorders; Restless Legs Syndrome; Sleep Wake Disorders; Parkinson Disease; Cognitive Dysfunction; Hepatic Insufficiency; Movement Disorders; Amyotrophic Lateral Sclerosis Details
Acetaminophen/Methylephedrine Hydrochloride/Dextromethorphan Hydrobromide/Chlorphenamine Maleate/Caffeine/Sulfogaiacol Approved Mainland China Common Cold Zhejiang Apeloa Kangyu Pharmaceutical Co Ltd Common Cold Details
Dextromethorphan Hydrobromide/Chlorphenamine Maleate/Sodium Citrate/Ammonium Chloride/Caffeine Approved 尔可芬 Cough Details
Acetaminophen/Caffeine/Codeine Phosphate/Diphenhydramine Hydrochloride Approved 斯力帮 Headache Details
Ferric Ammonium Citrate/Vitamin B1/Sodium glycerophosphate/Caffeine Approved Ischemia Details
Norethidranum Dipropionas/Caffeine/Vitamin B6 Approved Mainland China Contraception Huazhong Pharmaceutical Co Ltd 1981-01-01 Contraception Details
Acetaminophen/Propyphenazone/Caffeine Approved 散利痛, 散列通 Common Cold Details
Quinine Hydrochloride Hydrate/Caffeine Approved Malaria Details
Dihydroergocryptine/Caffeine Approved 洛斯宝, VASOBRAL Diabetic Retinopathy; Diabetes Mellitus Details
Aminophenazone/Phenacetin/Caffeine Approved Pain; Fever Details
Aminophenazone/Caffeine/Calcium Glycerophosphate Approved Headache; Dysmenorrhea; Neuralgia Details
Acetaminophen/Caffeine/Chlorphenamine Maleate Approved Common Cold Details
Aminophenazone/Caffeine/Chlorphenamine Maleate Approved Headache; Common Cold; Neuralgia Details
Aspirin/Caffeine/Codeine Phosphate Approved 柯克 Pain Details
Acetaminophen/Pseudoephedrine Hydrochloride/Caffeine Approved Common Cold Details
Aspirin/Acetaminophen/Caffeine/Chlorphenamine Maleate Approved Common Cold Details
Aspirin/Caffeine/Chlorphenamine Maleate/Tartaric Acid Approved Common Cold Details
Acetaminophen/Caffeine/Pseudoephedrine Hydrochloride/Chlorphenamine Maleate Approved Common Cold Details
Aminophenazone/Phenacetin/Caffeine/Phenobarbital Approved Migraine Disorders Details
Acetaminophen/Chlorphenamine Maleate/Caffeine/Guaifenesin Approved Common Cold Details
Acetaminophen/Amantadine Hydrochloride/Caffeine/Artificial Bezoar Approved Common Cold Details
Acetaminophen/Salicylamide/Pseudoephedrine Hydrochloride/Caffeine/Triprolidine Hydrochloride Hydrate Approved 联邦菲迪乐 Common Cold Details
Sodium Benzoate/Caffeine Approved Central Nervous System Diseases Details
Aminophenazone/Caffeine Approved Fever Details
Antipyrine/Caffeine Approved Common Cold Details
Aspirin/Caffeine Approved Common Cold Details
Antipyrine/Caffeine/Citric Acid Approved 米格来宁 Mainland China Sedation Xi'An Disai Biological Pharmaceutical Co Ltd, Heilongjiang Hasing Pharmaceutical Group Co Ltd, Huadong Medicine (Xi'An) Bodyguard Pharmaceutical Co Ltd, Mudanjiang Lingtai Medicdment Co Ltd 1982-01-01 Sedation Details
Aminophenazone/Acetaminophen/Caffeine/Chlorphenamine Maleate Approved 克感敏, 扑感敏, 朴感敏 Common Cold Details
Acetaminophen/Caffeine/Ephedrine Hydrochloride/Diphenhydramine Hydrochloride Approved Influenza, Human Details
Acetaminophen/Caffeine/Chlorphenamine Maleate/Artificial Bezoar Approved Common Cold Details
Aspirin/Phenacetin/Caffeine Approved Headache; Dysmenorrhea; Toothache; Neuralgia; Fever; Arthralgia Details
Aspirin/Caffeine/Acetaminophen Approved United States Migraine Disorders Haleon PLC Migraine Disorders; Anesthesia Details
Acetaminophen/Butalbital/Caffeine Approved Headache Details
Acetaminophen/Caffeine Approved Zentiva As Mainland China Pain Sino--American Shanghai Squibb Pharmaceutical Ltd Pain Details
Sodium glycerophosphate/Caffeine/Vitamin B/Phosphoric Acid/Niacin Approved Details
Acetaminophen/Caffeine/Phenylephrine Hydrochloride/Chlorphenamine Maleate/Vitamin B Approved Details
Acetaminophen/Chlorphenamine Maleate/Methylephedrine Hydrochloride/Sulfogaiacol/Caffeine Approved Mainland China Common Cold Hainan Sanfengyou Pharmaceutical Co Ltd 2006-05-16 Common Cold Details
Brompheniramine Maleate/Bromhexine Hydrochloride/Caffeine/Acetaminophen/Phenylephrine Hydrochloride Approved Common Cold Details
Acetaminophen/Amantadine Hydrochloride/Caffeine/Chlorphenamine Maleate/Artificial Bezoar Approved 复方氨酚烷胺 Mainland China Common Cold null 1984-01-01 Common Cold Details
Caffeine Approved Fatigue; Mental Fatigue; Memory Disorders; Cocaine-Related Disorders; Sexual Dysfunction, Physiological; Parkinson Disease; Cognitive Dysfunction; Diabetes Complications; Diabetic Nephropathies; Postoperative Cognitive Complications; Diabetes Mellitus, Type 1; Delirium; Apnea; Disorders of Excessive Somnolence; Intermittent Claudication; Spinal Cord Injuries; Fetal Membranes, Premature Rupture; Consciousness; Sleepiness Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Naproxen/Caffeine BAY-2880376 Phase 3 Clinical Bayer AG Pain, Postoperative Details
Caffeinol Phase 3 Clinical Cardium Therapeutics Alcoholic Intoxication; Stroke; Alcoholism; Disruptive, Impulse Control, and Conduct Disorders; Carcinoma, Non-Small-Cell Lung Details
Imaradenant AZD-4635; HTL-1071 Phase 2 Clinical Nxera Pharma UK Ltd Solid tumours; Prostatic Neoplasms, Castration-Resistant Details
Ciforadenant CPI-444; V-81444 Phase 2 Clinical Vernalis (R&D) Ltd Carcinoma, Renal Cell; Neoplasms; Attention Deficit Disorder with Hyperactivity; Multiple Myeloma; Parkinson Disease; Carcinoma, Non-Small-Cell Lung Details
Etrumadenant AB-928; GS-0928 Phase 2 Clinical Arcus Biosciences Inc Prostatic Neoplasms; Melanoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Endometrial Neoplasms; Laryngeal Neoplasms; Mouth Neoplasms; Pharyngeal Neoplasms; Carcinoma, Squamous Cell; Lung Neoplasms; Colorectal Neoplasms; Oropharyngeal Neoplasms; Breast Neoplasms; Ovarian Neoplasms; Urinary Bladder Neoplasms; Prostatic Neoplasms, Castration-Resistant; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Hypopharyngeal Neoplasms; Small Cell Lung Carcinoma; Esophageal Neoplasms; Carcinoma, Renal Cell; Carcinoma, Merkel Cell; Rectal Neoplasms; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Head and Neck Neoplasms Details
KW-6356 KW-6356 Phase 2 Clinical Kyowa Hakko Kirin Co Ltd Parkinson Disease; Hepatic Insufficiency Details
PORT-8 PORT-8; TT-53 Phase 2 Clinical Tarus Therapeutics Inc Solid tumours Details
PORT-6 PORT-6; TT-10 Phase 2 Clinical Impetis Biosciences Ltd Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Carcinoma, Non-Small-Cell Lung Details
VG081821AC Phase 2 Clinical Zhejiang Vimgreen Pharmaceuticals Ltd Parkinson Disease Details
ILB-2109 WTS-001; ILB-2109 Phase 2 Clinical Hangzhou Wutong Tree Pharmaceutical Co Ltd Solid tumours; Neoplasms Details
PBF-999 PBF-999 Phase 1 Clinical Palobiofarma Sl Neoplasms; Huntington Disease Details
SHR-5126 SHR-5126 Phase 1 Clinical Jiangsu Hengrui Medicine Co Ltd Neoplasms Details
Taminadenant NIR-178; PBF-509 Phase 1 Clinical Palobiofarma Sl Solid tumours; Ovarian Neoplasms; Head and Neck Neoplasms; Carcinoma, Renal Cell; Carcinoma; Triple Negative Breast Neoplasms; Lymphoma, Large B-Cell, Diffuse; Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Colorectal Neoplasms; Parkinson Disease; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Melanoma Details
ST-4206 ST-4206 Phase 1 Clinical Alfasigma Spa Parkinson Disease Details
JNJ-86974680 JNJ-86974680 Phase 1 Clinical Johnson & Johnson Enterprise Innovation Inc Carcinoma, Non-Small-Cell Lung Details
YZJ-5053 YZJ5053; YZJ-5053 Phase 1 Clinical Shanghai Haiyan Pharmaceutical Technology Co Ltd Solid tumours; Neoplasm Metastasis Details
DZD-2269 Phase 1 Clinical Dizal Pharmaceutical Co Ltd Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms Details
INCB-106385 INCB-106385 Phase 1 Clinical Incyte Corp Solid tumours; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Triple Negative Breast Neoplasms; Prostatic Neoplasms, Castration-Resistant; Urinary Bladder Neoplasms; Colorectal Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Neoplasms; Carcinoma, Hepatocellular Details
CS-3005 CS-3005 Phase 1 Clinical Cstone Pharmaceuticals (Suzhou) Co Ltd Solid tumours Details
Sodium Citrate/Citric Acid/Dextrose/Monosodium phosphate/Adenine/Mannitol/Sodium Chloride Details
Sodium Citrate/Citric Acid/Dextrose Details
Sodium Citrate/Citric Acid/Dextrose/Monosodium phosphate/Adenine Details
Aspirin/Acetaminophen/Caffeine/Thiamine Details
Propranolol hydrochloride/Caffeine/Phenytoin Sodium Details
Ethenzamide/Caffeine/Chlorzoxazone Details
Salicylamide/Acetaminophen/Caffeine Details

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