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Brief Information

Name:Serine/threonine-protein kinase AKT
Target Synonym:EC:,EC 2.7.11,Proto-oncogene c-Akt,Protein kinase B,RAC,RAC-PK-alpha,PKB alpha,RAC-alpha serine/threonine-protein kinase,AKT1,AKT Serine/Threonine Kinase 1,Protein Kinase B Alpha,PKB,Serine-Threonine Protein Kinase,Rac Protein Kinase Alpha,EC 2.7.
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:19
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
AK1-H5283 Human Human Akt1 Protein, His,Strep II Tag

Synonym Name

AKT1,PKB,RAC,RAC-PK-alpha,PKB alpha


RAC-alpha serine/threonine-protein kinase (AKT1) is also known PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt and RAC-PK-alpha, which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and RAC subfamily and is expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase).

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Uprosertib GSK-795; GSK-2141795; GSK-2141795C Phase 2 Clinical Novartis Pharma Ag, National Cancer Institute, Glaxosmithkline Plc Neoplasms; Multiple Myeloma; Breast Neoplasms; Leukemia, Myeloid, Acute; Endometrial Neoplasms; Melanoma; Uterine Cervical Neoplasms Details
HZB0071 HZB-0071 Phase 1 Clinical Wuxi Apptec Co Ltd, Heilongjiang Zbd Pharmaceutical Co Ltd Neoplasms Details
GSK-690693 GSK-690693 Phase 1 Clinical Glaxosmithkline Plc Neoplasms; Lymphoma Details
Hu-7691 Hu7691 Phase 1 Clinical Zhejiang University Neoplasms Details
CMX-2043 LIP-EA; CMX-2043; R-LIP-EA-OH Phase 2 Clinical Ischemix Reperfusion Injury; Angina, Unstable; Coronary Artery Disease Details
Triciribine Phosphate API-2; TCN-P; PTX-002; VQD-002; NSC-154020; NSC-280594; VQD-002-ORAL Phase 2 Clinical National Cancer Institute Ovarian Neoplasms; Leukemia; Hematologic Neoplasms; Breast Neoplasms; Leukemia, Myeloid, Acute Details
CLR-124 CLR-124; [124I]NM-404; NM-404-[124I]; [124I]CLR-1404; CLR-1404-[124I] Phase 2 Clinical University Of Michigan Glioblastoma; Diagnostic agents Details
Oxysterols (Intsel Chimos) Clinical Centre National De La Recherche Scientifique (Cnrs) Glioma Details
Honokiol HU-002 Phase 3 Clinical Anacor Pharmaceuticals Non-alcoholic Fatty Liver Disease; Gingival Diseases Details
Uprosertib/Trametinib Dimethyl Sulfoxide Phase 2 Clinical Novartis Pharma Ag Leukemia, Myeloid, Acute; Endometrial Neoplasms; Uterine Cervical Neoplasms Details
Selumetinib sulfate/MK-2206 Phase 2 Clinical Astrazeneca Plc, Merck & Co Inc Triple Negative Breast Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma Details
MK-2206 MK2206; MK-2206; BIND-2206; NSC-749607 Phase 2 Clinical Merck Sharp & Dohme Corp Solid tumours; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
ACC-006 ACC-006 Phase 2 Clinical Jiangsu Aidea Pharmaceutical Co Ltd, China Pharmaceutical University Solid tumours; Carcinoma, Non-Small-Cell Lung Details
TAS-117 TAS-117 Phase 2 Clinical Otsuka Pharmaceutical Co Ltd, Taiho Pharmaceutical Co Ltd Solid tumours; Neoplasms Details
Afuresertib ASB-183; GSK-2110183B; GSK-2110183C; GSK-21110183; LAE-002; GSK-2110183 Phase 2 Clinical Glaxosmithkline Plc, Novartis Pharma Ag Ovarian Neoplasms; Hematologic Neoplasms; Solid tumours; Neoplasms; Triple Negative Breast Neoplasms; Multiple Myeloma; Prostatic Neoplasms; Histiocytosis, Langerhans-Cell; Breast Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell Details
TIC-10 TIC-10; ONC-201; NSC-350625; ONC201/TIC10; ONC201 - Oncoceutics Phase 2 Clinical Oncoceutics Glioblastoma; Triple Negative Breast Neoplasms; Thalamic Diseases; Multiple Myeloma; Neuroendocrine Tumors; Breast Neoplasms; Diffuse Intrinsic Pontine Glioma; Colorectal Neoplasms; Glioma; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Capivasertib AZD-5363 Phase 3 Clinical Astrazeneca Pharmaceutical Co Ltd Solid tumours; Ovarian Neoplasms; Hematologic Neoplasms; Triple Negative Breast Neoplasms; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Prostatic Neoplasms; Metastatic breast cancer; Endometrial Neoplasms; Uterine Cervical Neoplasms Details
Ipatasertib Dihydrochloride RG-7440; GCD-0068; GDC-0068; RO-5532961 Phase 3 Clinical Array Biopharma, F. Hoffmann-La Roche Ltd Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Triple Negative Breast Neoplasms; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Prostatic Neoplasms; Hepatic Insufficiency; Neoplasms, Unknown Primary; Gastrointestinal Neoplasms; Neoplasm Metastasis Details
Miransertib ARQ-092 Phase 2 Clinical Arqule Ovarian Neoplasms; Solid tumours; Proteus Infections; Growth Disorders; Lymphoma; Endometrial Neoplasms; Proteus Syndrome Details
CLR-131 HOT; NM404; CLR-131; 131I-NM-404; (131)I-NM 404; CLR1404 I-131; (131)I-CLR1404; I-131-CLR1404 Phase 2 Clinical University Of Michigan Sarcoma, Ewing; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Waldenstrom Macroglobulinemia; Glioma; Lymphoma; Diffuse Intrinsic Pontine Glioma; Lymphoma, Mantle-Cell; Brain Neoplasms; Solid tumours; Neuroblastoma; Osteosarcoma; Central Nervous System Neoplasms; Multiple Myeloma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, B-Cell, Marginal Zone; Rhabdomyosarcoma Details

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