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Your Position: Home > Akt1

Akt1

Brief Information

Name:Serine/threonine-protein kinase AKT
Target Synonym:EC 2.7.11,EC 2.7.11.1,PKB-ALPHA,RAC-ALPHA,AKT1m,PRKBA,CWS6,AKT,PKB alpha,RAC-alpha serine/threonine-protein kinase,AKT1,AKT Serine/Threonine Kinase 1,Protein Kinase B Alpha,PKB,Serine-Threonine Protein Kinase,Rac Protein Kinase Alpha,Proto-oncogene c-Akt,Protein kinase B,RAC,RAC-PK-alpha,V-Akt Murine Thymoma Viral Oncogene-Like Protein 1,V-Akt Murine Thymoma Viral Oncogene Homolog 1,EC:2.7.11.1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:20
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
AK1-H5283 Human Human Akt1 Protein, His,Strep II Tag
AK1-H5283-structure
AK1-H5283-sds

Synonym Name

AKT1,PKB,RAC,RAC-PK-alpha,PKB alpha

Background

RAC-alpha serine/threonine-protein kinase (AKT1) is also known PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt and RAC-PK-alpha, which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and RAC subfamily and is expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase).

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Uprosertib/Trametinib Dimethyl Sulfoxide Phase 2 Clinical Novartis Pharma Ag Leukemia, Myeloid, Acute; Endometrial Neoplasms; Uterine Cervical Neoplasms Details
Hu-7691 Hu-7691 Phase 1 Clinical Zhejiang University Neoplasms Details
Oxysterols (Intsel Chimos) Clinical Centre National De La Recherche Scientifique (Cnrs) Glioma Details
NTQ-1062 NTQ1062; NTQ-1062 Phase 1 Clinical Nanjing Zhengda Tianqing Pharmaceutical Co Ltd Solid tumours Details
MK-2206 MK2206; MK-2206; BIND-2206; NSC-749607 Merck Sharp & Dohme Corp Details
Uprosertib GSK-795; GSK-2141795; GSK-2141795C; UPB-795 Glaxosmithkline Plc, Novartis Pharma Ag, National Cancer Institute Details
Palomids P-529; P-52901; RES-529; SG-00529; Palomid-529 Diffusion Pharmaceuticals Details
Honokiol HU-002; JRF-101 Phase 1 Clinical Anacor Pharmaceuticals Carcinoma, Non-Small-Cell Lung Details
XL-418 XL-418; EXEL-9418 Exelixis Details
MSC-2363318A M-2698; MSC-2363318A Merck Serono Details
Iopofosine I-131 HOT; CLR1404 I-131; I-131-CLR1404; (131)I-NM 404; 131I-NM-404; CLR-131; (131)I-CLR1404; NM404 University Of Michigan Details
BAY-1125976 BAY-1125976 Bayer AG Details
Selumetinib sulfate/MK-2206 Phase 2 Clinical Astrazeneca Plc, Merck & Co Inc Triple Negative Breast Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma Details
Ipatasertib Dihydrochloride RG-7440; GCD-0068; GDC-0068; RO-5532961 Phase 3 Clinical Array Biopharma, F. Hoffmann-La Roche Ltd Ovarian Neoplasms; Solid tumours; Neoplasm, Residual; Stomach Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Glioblastoma; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Prostatic Neoplasms; Hepatic Insufficiency; Endometrial Neoplasms; Neoplasms, Unknown Primary; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
TAS-117 TAS-117 Phase 2 Clinical Otsuka Pharmaceutical Co Ltd, Taiho Pharmaceutical Co Ltd Solid tumours Details
Miransertib MK-7075; ARQ-092 Phase 2 Clinical Arqule Inc Proteus Infections Details
Triciribine Phosphate NSC-154020; PTX-002; API-2; TCN-P; VQD-002-ORAL; VQD-002; NSC-280594; PTX-200 Phase 2 Clinical National Cancer Institute Ovarian Neoplasms; Hematologic Neoplasms; Leukemia; Neoplasms; Breast Neoplasms Details
HZB-0071 HZB-0071 Phase 1 Clinical Wuxi Apptec Co Ltd, Heilongjiang Zbd Pharmaceutical Co Ltd Neoplasms Details
TIC-10 ONC201 - Oncoceutics; ONC201/TIC10; NSC-350625; TIC-10; ONC-201 Phase 3 Clinical Oncoceutics Solid tumours; Glioblastoma; Triple Negative Breast Neoplasms; Myelodysplastic Syndromes; Thalamic Diseases; Multiple Myeloma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Gliosarcoma; Colorectal Neoplasms; Diffuse Intrinsic Pontine Glioma; Leukemia, Myeloid, Acute; Endometrial Neoplasms; Glioma; Carcinoma, Non-Small-Cell Lung Details
RX-0301 RX-0201 nanoliposomal; RX-0201 Nano; RX-0201-N; RX-0301; WGI-0301; RX-0201 Phase 1 Clinical Rexahn Pharmaceuticals Solid tumours; Liver Neoplasms; Carcinoma, Renal Cell; Neoplasms; Pancreatic Neoplasms Details
Capivasertib AZD-5363 Phase 3 Clinical Astrazeneca Pharmaceutical Co Ltd Solid tumours; Ovarian Neoplasms; Hematologic Neoplasms; Neoplasms; Triple Negative Breast Neoplasms; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Prostatic Neoplasms; Lymphoma, Non-Hodgkin; Metastatic breast cancer; Carcinoma, Squamous Cell; Endometrial Neoplasms; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
Afuresertib ASB-183; GSK-2110183; GSK-2110183B; GSK-2110183C; GSK-21110183; LAE-002 Phase 3 Clinical Glaxosmithkline Plc, Novartis Pharma Ag Histiocytosis, Langerhans-Cell; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Leukemia, Lymphocytic, Chronic, B-Cell; Endometrial Neoplasms; Metastatic breast cancer; Fallopian Tube Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Ovarian Neoplasms; Breast Neoplasms; Multiple Myeloma; Neoplasms; Triple Negative Breast Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Solid tumours; Hematologic Neoplasms Details

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