Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Akt1

Akt1

Brief Information

Name:Serine/threonine-protein kinase AKT1
Target Synonym:EC:2.7.11.1,EC 2.7.11,Proto-oncogene c-Akt,Protein kinase B,RAC,RAC-PK-alpha,PKB alpha,RAC-alpha serine/threonine-protein kinase,AKT1,AKT Serine/Threonine Kinase 1,V-Akt Murine Thymoma Viral Oncogene Homolog 1,Protein Kinase B Alpha,PKB,V-Akt Murine Thymoma Viral Oncogene-Like Protein 1,Serine-Threonine Protein Kinase,Rac Protein Kinase Alpha,EC 2.7.11.1,PKB-ALPHA,RAC-ALPHA,AKT1m,PRKBA,CWS6,AKT
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:21
Lastest Research Phase:Approved

Product ListCompare or Buy

By Product Status:
By Product Category:
By Species:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
AK1-H5283 Human Human Akt1 Protein, His,Strep II Tag
AK1-H5283-structure
AK1-H5283-sds
ACRO Quality

Synonym Name

AKT1,PKB,RAC,RAC-PK-alpha,PKB alpha

Background

RAC-alpha serine/threonine-protein kinase (AKT1) is also known PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt and RAC-PK-alpha, which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and RAC subfamily and is expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase).

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Capivasertib AZD-5363 Approved Astex Pharmaceuticals Inc, Cancer Research Technology, The Institute Of Cancer Research, London Truqap United States Breast Neoplasms Astrazeneca Pharmaceuticals Lp 2023-11-16 Uterine Neoplasms; Multiple Myeloma; Breast Neoplasms; Prostatic Neoplasms; Hormone-Sensitive Prostate Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Endometrial Neoplasms; Glioma; Metastatic breast cancer; Urinary Bladder Neoplasms; Lymphoma; Lung Neoplasms; Thyroid Neoplasms; HR-positive breast cancer; Fallopian Tube Neoplasms; Lymphoma, Non-Hodgkin; Uterine Cervical Neoplasms; Melanoma; Esophageal Neoplasms; Ovarian Neoplasms; Head and Neck Neoplasms; Hematologic Neoplasms; Liver Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Rectal Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Carcinoma, Ovarian Epithelial; Skin Neoplasms; Neoplasms; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Colonic Neoplasms; Prostatic Neoplasms, Castration-Resistant Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Afuresertib GSK-21110183; GSK-2110183B; GSK-2110183C; LAE002; ASB-183; GSK-2110183; LAE-002 Phase 3 Clinical Novartis Pharma Ag, Glaxosmithkline Plc Breast Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Leukemia, Lymphocytic, Chronic, B-Cell; Endometrial Neoplasms; Metastatic breast cancer; Fallopian Tube Neoplasms; Peritoneal Neoplasms; Histiocytosis, Langerhans-Cell; Hematologic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Multiple Myeloma; Triple Negative Breast Neoplasms; Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Solid tumours; Ovarian Neoplasms Details
Ipatasertib RG-7440; GCD-0068; GDC-0068; RO-5532961 Phase 3 Clinical Array Biopharma, Genentech Inc Lymphoma, Non-Hodgkin; Hepatic Insufficiency; Neoplasms, Unknown Primary; Laryngeal Neoplasms; Paranasal Sinus Diseases; Endometrial Neoplasms; Carcinoma, Squamous Cell; Metastatic breast cancer; Paranasal Sinus Neoplasms; Mouth Neoplasms; Genital Neoplasms, Female; Fallopian Tube Neoplasms; Urogenital Neoplasms; Lymphoma; Lip Neoplasms; Carcinoma, Endometrioid; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Hypopharyngeal Neoplasms; Solid tumours; Head and Neck Neoplasms; Ovarian Neoplasms; Cystadenocarcinoma, Serous; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Neoplasm, Residual; Glioblastoma; Prostatic Neoplasms, Castration-Resistant; Multiple Myeloma; Breast Neoplasms; Prostatic Neoplasms; Cholangiocarcinoma; Oropharyngeal Neoplasms; Peritoneal Neoplasms Details
SR-0379 SR-0379 Phase 3 Clinical FunPep Co Ltd Skin Ulcer Details
Triciribine Phosphate NSC-154020; PTX-002; API-2; TCN-P; VQD-002-ORAL; VQD-002; NSC-280594; PTX-200 Phase 2 Clinical National Cancer Institute Hematologic Neoplasms; Leukemia; Ovarian Neoplasms; Neoplasms; Breast Neoplasms Details
Miransertib MK-7075; ARQ-092 Phase 2 Clinical Arqule Inc Ovarian Neoplasms; Solid tumours; Proteus Infections; Neoplasms; PIK3CA-Related Overgrowth Spectrum; Lymphoma; Endometrial Neoplasms; Proteus Syndrome Details
Iopofosine I-131 CLR-131; NM404; (131)I-CLR1404; 131I-NM-404; HOT; CLR1404 I-131; I-131-CLR1404; (131)I-NM 404 Phase 2 Clinical University Of Michigan Neuroblastoma; Leukemia, Lymphocytic, Chronic, B-Cell; Central Nervous System Lymphoma; Glioma; Lymphoma; Waldenstrom Macroglobulinemia; Diffuse Intrinsic Pontine Glioma; Brain Neoplasms; Osteosarcoma; Lymphoma, B-Cell, Marginal Zone; Sarcoma, Ewing; Lymphoma, Mantle-Cell; Multiple Myeloma; Neoplasms; Lymphoma, Large B-Cell, Diffuse; Head and Neck Neoplasms; Solid tumours; Rhabdomyosarcoma Details
Ursolic Acid NSC-167406; NSC-4060 Phase 2 Clinical University Of Guadalajara Prostatic Neoplasms; Carcinoma, Hepatocellular; Sarcopenia; Lung Neoplasms; Muscular Atrophy; Colorectal Neoplasms; Quadriplegia; Cholangitis, Sclerosing; Breast Neoplasms; Liver Neoplasms; Pancreatic Neoplasms; Colonic Neoplasms; Insulin Resistance; Metabolic Syndrome; Paraplegia; Spinal Cord Injuries; Stomach Neoplasms Details
Uprosertib/Trametinib Dimethyl Sulfoxide Phase 2 Clinical Novartis Pharma Ag Endometrial Neoplasms; Leukemia, Myeloid, Acute; Uterine Cervical Neoplasms Details
Selumetinib sulfate/MK-2206 Phase 2 Clinical Astrazeneca Plc, Merck & Co Inc Rectal Neoplasms; Triple Negative Breast Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lung Neoplasms; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung Details
Uprosertib GSK-795; GSK-2141795; GSK-2141795C; UPB-795 Phase 2 Clinical Glaxosmithkline Plc, Novartis Pharma Ag, National Cancer Institute Solid tumours; Hematologic Neoplasms; Skin Melanoma; Neoplasms; Triple Negative Breast Neoplasms; Uveal melanoma; Multiple Myeloma; Adenocarcinoma, Clear Cell; Breast Neoplasms; Endometrial Neoplasms; Uterine Neoplasms; Lymphoma; Leukemia, Myeloid, Acute; Melanoma; Uterine Cervical Neoplasms Details
RX-0301 WGI-0301; RX-0201改良型; HC0301; RX-0201 nanoliposomal; RX-0201 Nano; RX-0201-N; RX-0301 Phase 2 Clinical Rexahn Pharmaceuticals Inc Liver Neoplasms; Solid tumours; Carcinoma, Hepatocellular Details
MK-2206 MK2206; MK-2206; BIND-2206; NSC-749607 Phase 2 Clinical Merck Sharp & Dohme Corp Colorectal Neoplasms; Lymphoma, T-Cell; Waldenstrom Macroglobulinemia; Intraocular Lymphoma; Lymphoma; Lymphoma, Large-Cell, Anaplastic; Glioma; Leukemia, Myelomonocytic, Juvenile; Lymphoma, T-Cell, Cutaneous; Neoplasms, Gonadal Tissue; Lung Neoplasms; Carcinoma, Squamous Cell; Leukemia, Myeloid, Acute; Lymphoproliferative Disorders; Leukemia, Myeloid, Chronic-Phase; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Peritoneal Neoplasms; Adenocarcinoma, Bronchiolo-Alveolar; Sezary Syndrome; Bile Duct Neoplasms; Prostatic Neoplasms; Lymphoma, Follicular; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Adenocarcinoma; Leukemia, T-Cell; Melanoma; Carcinoma, Non-Small-Cell Lung; Leukemia, Large Granular Lymphocytic; Leukemia, Prolymphocytic; Breast Neoplasms, Male; Mycosis Fungoides; Carcinoma, Hepatocellular; Central Nervous System Lymphoma; Leukemia, Lymphocytic, Chronic, B-Cell; Cholangiocarcinoma; Angioimmunoblastic T-cell Lymphoma; Endometrial Neoplasms; Lymphoma, Non-Hodgkin; Thymoma; Gallbladder Neop Details
NTQ-1062 NTQ-1062; NTQ1062 Phase 2 Clinical Nanjing Zhengda Tianqing Pharmaceutical Co Ltd Solid tumours; Breast Neoplasms; HR-positive breast cancer Details
HZB-0071 HZB-0071 Phase 1 Clinical Wuxi Apptec Co Ltd, Heilongjiang Zbd Pharmaceutical Co Ltd Neoplasms Details
Rupitasertib DIACC3010; M-2698; MSC-2363318A; DIACC-3010 Phase 1 Clinical Emd Serono Inc Solid tumours; Stomach Neoplasms; Glioblastoma; Breast Neoplasms Details
Honokiol HU-002; JRF-101 Phase 1 Clinical Anacor Pharmaceuticals Inc Metabolic Dysfunction-Associated Steatotic Liver Disease; Gingival Diseases; Carcinoma, Non-Small-Cell Lung Details
CMX-2043 LIP-EA; CMX-2043; R-LIP-EA-OH Phase 1 Clinical Ischemix Llc Brain Injuries, Traumatic; Angina, Unstable; Coronary Artery Disease; Cardiovascular Diseases; Non-ST Elevated Myocardial Infarction Details
ALTA-2618 ALTA-2618 Phase 1 Clinical Alterome Therapeutics Inc Solid tumours; Neoplasms; Breast Neoplasms; Endometrial Neoplasms; Neoplasm Metastasis Details
Hu-7691 Hu-7691 Phase 1 Clinical Zhejiang University Solid tumours; Neoplasms Details
Oxysterols (Intsel Chimos) Clinical Centre National De La Recherche Scientifique (Cnrs) Glioma Details

This web search service is supported by Google Inc.

totop
Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA

Leave a message