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Cathepsin B

Cathepsin B Molecule Information

Name:Cathepsin B
Target Synonym:Cathepsin B1;CPSB;Cathepsin B;APP secretase;CTSB;APPS;Cathepsin B heavy chain;Cathepsin B light chain
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
CTB-H5222 Human Human Cathepsin B / CTSB Protein, His Tag

Cathepsin B Molecule Synonym Name


Cathepsin B Molecule Background

Cathepsin B (CTSB) is also known as APP secretase (APPS) and CPSB, is an enzymatic protein belonging to the peptidase C1 family. Cathepsin B / CTSB is synthesized as a preproenzyme. Following removal of the signal peptide, the inactive proenzyme undergoes further modifications including removal of the pro region to result in the active enzyme. The catalytic activity of Cathepsin B / APPS contains: Hydrolysis of proteins with broad specificity for peptide bonds; Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L); In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides. As a thiol protease, cathepsin B / CPSB is believed to participate in intracellular degradation and turnover of proteins and has also been implicated in tumor invasion and metastasis. Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors.

Cathepsin B References

Cathepsin B Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
BI-1181181 BI-1181181; VTP-37948 Phase Ⅰ Vitae, Boehringer Ingelheim Alzheimer's disease (AD) Details
VBY-376 VBY-376,VBY376 Phase Ⅰ ViroBay Hepatic fibrosis, Non-alcoholic steatohepatitis Details
Aoxistatin AB-007; E-64-d Phase Ⅲ Taisho Pharmaceutical, Sumitomo Dainippon Muscular dystrophy Details
VBY-825 VBY-106; VBY-285; VBY-825 Preclinical ViroBay Neuropathic pain, Bone cancer, Autoimmune diseases, Alzheimer's disease (AD) Details
Begacestat Begacestat; GSI-953; WAY-210953 Phase Ⅰ Pfizer Alzheimer's disease (AD) Details
AL-101 AL-101; BMS-906024 Phase Ⅱ Bristol-Myers Squibb, Ayala Pharmaceuticals Adenoid cystic carcinoma Details
BMS-986115 AL-102; BMS-986115 Phase Ⅰ Bristol-Myers Squibb hematological malignancies, Solid tumours, Multiple myeloma (MM) Details
MK-0752 MK-0752; L-000891675,MK0752,L000891675 Phase Ⅱ Merck Sharp & Dohme, National Cancer Institute Breast cancer, Solid tumours, Pancreatic cancer Details
EVP-0962 EVP-0962; EVP-0015962 Phase Ⅱ FORUM pharmaceuticals Alzheimer's disease (AD) Details

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