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Your Position: Home > Cathepsin L

Cathepsin L

Brief Information

Name:Cathepsin L
Target Synonym:Cathepsin L1,CATL,CTSL,MEP,EC:3.4.22.15,CTSL1,Major Excreted Protein,Cathepsin L,FLJ31037
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CAL-H52H3 Human Human Cathepsin L / CTSL1 Protein, His Tag (active enzyme)
CAL-H52H3-structure
CAL-H52H3-sds
CAL-M52H3 Mouse Mouse Cathepsin L / CTSL1 Protein, His Tag (MALS verified)
CAL-M52H3-structure
CAL-M52H3-sds
ACRO Quality

Part of Bioactivity data

CAL-M52H3-MALS-HPLC
Cathepsin L MALS images

The purity of Mouse Cathepsin L Protein, His Tag (Cat. No. CAL-M52H3) is more than 90% and the molecular weight of this protein is around 35-50 kDa verified by SEC-MALS.

CAL-H52H3-ELISA
Cathepsin L ELISA

Immobilized Human Cathepsin L Protein, His Tag (Cat. No. CAL-H52H3) at 5 μg/mL (100 μL/well) can bind Human CD74, Fc Tag (Cat. No. CD4-H5256) with a linear range of 0.005-1.25 μg/mL (Routinely tested).

Protocol

Synonym Name

CTSL1,MEP,CATL,CTSL

Background

Cathepsin L (CTSL1) is also known as major excreted protein (MEP), is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains linked by disulfide bonds. CTSL1 is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. MEP has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. CTSL1 is important for the overall degradation of proteins in lysosomes. The specificity of MEP is close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z - Arg ¨C Arg ¨C NHMec, and no peptidyl - dipeptidase activity. Human Cathepsin L activity is greatest under mildly acidic conditions, from pH 4.5

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Olgotrelvir STI1558; STI-1558 Phase 3 Clinical Texas A&M University Coronavirus Disease 2019 (COVID-19) Details

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