CXADR Protein - ACROBiosystems

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CXADR

Brief Information

Name:Calcium sensing receptor
Target Synonym:Extracellular calcium-sensing receptor,hCasR,GPRC2A,Calcium Sensing Receptor,Parathyroid Ca(2+)-Sensing Receptor 1,Severe Neonatal Hyperparathyroidism,Calcium-Sensing Receptor,HYPOC1,NSHPT,PCaR1,EIG8,HHC1,CaSR,CAR,FHH,FIH,HHC,Receptors, Calcium-Sensing,Hy

Number of Launched Drugs:5
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Approved


CXR-H5222	Human	Human CXADR / CAR Protein, His Tag

Cat. No.

Species

Product Description

Structure

Purity

Feature

CXR-H5222

Human

Human CXADR / CAR Protein, His Tag

Synonym Name

CXADR,CAR,CAR4/6,HCAR

Background

Coxsackie virus and adenovirus receptor (CXADR) is also known as CAR, is a type I transmembrane glycoprotein for group B coxsackie viruses and subgroup C adenoviruses, and belongs to the CTX family of the Ig superfamily. CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins such as: fibronectin, agrin, laminin-1 and tenascin-R. Human

Public Drug Information

Name	Research Code	Research Phase	Company	First Brand Name	First Approved Country	First Indication	First Approved Company	First Approved Date	Indications	Clinical Trials
Evocalcet	MT-4580; KHK-7580	Approved	Mitsubishi Tanabe Pharma Corp	Orkedia	Japan	Hyperparathyroidism, Secondary	Kyowa Hakko Kirin	2018-03-23	Hyperparathyroidism, Secondary; Parathyroid Neoplasms; Hyperparathyroidism, Primary; Hyperparathyroidism	Details
Parathyroid hormone (Shire)	423562; ALX-111; SHP-634; SHP-635; NPSP-558; NPSP-795; PTH 1-84; SB-423562; PTH (1-84); rhPTH-1-84; rhPTH (1-84)	Approved	Shire	Natpar, Natpara, Preotact	EU	Hypoparathyroidism	Shire Pharmaceuticals Ireland Ltd	2006-04-24	Osteoporosis; Osteoporosis, Postmenopausal; Hypoparathyroidism	Details
Upacicalcet	SK-1403; AJT-240	Approved	Ea Pharma	Upasita	Japan	Hyperparathyroidism, Secondary	Sanwa Kagaku Kenkyusho	2021-06-23	Hyperparathyroidism, Secondary; Hyperparathyroidism	Details
Etelcalcetide Hydrochloride	AMG-416; KAI-4169; KAI-4169-HCl; ONO-5163	Approved	Amgen Inc	Parsabiv	United States	Hyperparathyroidism, Secondary	Kai Pharmaceuticals	2016-11-11	Hyperparathyroidism, Secondary; Edema, Cardiac; Renal Insufficiency, Chronic	Details
Cinacalcet Hydrochloride	AMG-073; KRN-1493; NPS-1493; AMG-073.HCl	Approved	Amgen Inc	盖平, Mimpara, Parareg, Regpara, Sensipar, Sensipar/Mimpara	Mainland China	Hypercalcemia; Hyperparathyroidism; Hyperparathyroidism, Secondary	Kyowa Hakko Kirin	2004-03-08	Hyperparathyroidism, Secondary; Rejection of renal transplantation; Parathyroid Neoplasms; Hypophosphatemia; Nephrosis; Edema, Cardiac; Hypercalcemia; Kidney Diseases; Hyperparathyroidism, Primary; Renal Insufficiency, Chronic; Kidney Failure, Chronic; Hyperparathyroidism; Chronic Kidney Disease-Mineral and Bone Disorder	Details
Strontium Ranelate	FK-481; S-12911; S-12911-2	Approved	Servier	欧思美, Osseor, Protos, Protelos	Mainland China	Osteoporosis, Postmenopausal	Les Laboratoires Servier	2004-09-20	Osteoporosis, Postmenopausal	Details

Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
LNP-1892	LNP-1892	Phase 2 Clinical	Rubin Ltd	Hyperparathyroidism	Details
Encaleret sulfate	MK-5442; JTT-305; CLTX-305	Phase 2 Clinical	Japan Tobacco (Hong Kong) Ltd	Osteoporosis; Hypocalcemia; Osteoporosis, Postmenopausal	Details
DS-9194b	DS-9194b	Phase 1 Clinical	Daiichi Sankyo Co Ltd	Osteoporosis	Details