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DDR2 Molecule Information

Name:Discoidin domain-containing receptor 2
Target Synonym:TKT;Discoidin domain receptor 2;Discoidin domain-containing receptor tyrosine kinase 2;Receptor protein-tyrosine kinase TKT;NTRKR3 ;Neurotrophic tyrosine kinase, receptor-related 3;TYRO10;CD167 antigen-like family member B;CD_antigen=CD167b;Tyrosine-prote
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Approved

DDR2 Molecule Synonym Name


DDR2 Molecule Background

Discoidin domain-containing receptor 2 (DDR2) is also known as CD167 antigen-like family member B (CD167b), Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3(NTRKR3), Tyrosine-protein kinase TYRO10, Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. DDR2 is required for normal bone development. DDR2 regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. DDR2 regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. DDR2 promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

DDR2 References

DDR2 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Regorafenib Monohydrate BAY-73-4506; DAST,BAY73-4506,BAY 73-4506,BAY-734506 Approved Bayer, Onyx Pharmaceutical STIVARGA fda Gastrointestinal stromal tumors (GISTs), Metastatic colorectal cancer (CRC) BAYER HLTHCARE 2012-09-27 Gastrointestinal stromal tumors (GISTs), Liver cancer, Metastatic colorectal cancer (CRC), Hepatocellular carcinoma (HCC) Details

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