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Brief Information

Name:Discoidin domain-containing receptor 2
Target Synonym:CD167b,NTRKR3,CD167 Antigen-Like Family Member B,Discoidin Domain Receptor 2,Hydroxyaryl-Protein Kinase,CD167b Antigen,Discoidin Domain-Containing Receptor 2,Tyrosine-Protein Kinase TYRO10,Discoidin Domain-Containing Receptor Tyrosine Kinase 2,TKT,Discoid
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved
ACRO Quality

Synonym Name



Discoidin domain-containing receptor 2 (DDR2) is also known as CD167 antigen-like family member B (CD167b), Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3(NTRKR3), Tyrosine-protein kinase TYRO10, Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. DDR2 is required for normal bone development. DDR2 regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. DDR2 regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. DDR2 promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

Clinical and Translational Updates

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