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Brief Information

Name:Delta Like Canonical Notch Ligand 1
Target Synonym:Delta Like Canonical Notch Ligand 1,Drosophila Delta Homolog 1,Delta-Like Protein 1,H-Delta-1,Epididymis Secretory Sperm Binding Protein,Delta (Drosophila)-Like 1,Delta-Like 1 (Drosophila),DELTA1,NEDBAS,Delta1,Delta,DL1,Drosophila Delta homolog 1 (Delta1; H-Delta-1)
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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ACRO Quality

Part of Bioactivity data


Loaded Human NOTCH1, Fc Tag (Cat. No. NO1-H5255) on Protein A Biosensor, can bind Human DLL1 Protein, His Tag, premium grade (Cat. No. DL1-H52H8) with an affinity constant of 290 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

DLL1 MALS images

The purity of Biotinylated Human DLL1 Protein, His,Avitag, premium grade (Cat. No. DL1-H82E5) is more than 90% and the molecular weight of this protein is around 60-80 kDa verified by SEC-MALS.

Synonym Name



Delta-like protein 1 (DLL1) is also known as Drosophila Delta homolog 1 (Delta1 or H-Delta-1), which contains one DSL domain and eight EGF-like domains. DLL1 is ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. As for expression, DLL1 is expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. Furthermore, DLL1 acts as a ligand for Notch receptors. Also, DLL1 can block the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.

Clinical and Translational Updates

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