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Dkk-3

Brief Information

Name:Dickkopf-related protein 3
Target Synonym:UNQ258/PRO295,Dickkopf-3,Dickkopf-related protein 3,hDkk-3,REIC,DKK3,Dickkopf WNT Signaling Pathway Inhibitor 3,Regulated In Glioma,Dkk-3,Dickkopf (Xenopus Laevis) Homolog 3,Dickkopf 3 Homolog,Dickkopf Homolog 3,RIG-Like 5-6,RIG-Like 7-1,RIG,Dickkopf 3 Ho
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
DK3-M5226 Mouse Mouse Dkk-3 Protein, His Tag
DK3-M5226-structure
DK3-M5226-sds
DK3-H5220 Human Human Dkk-3 (R335G) Protein, His Tag
DK3-H5220-structure
DK3-H5220-sds

Synonym Name

DKK3,REIC,RIG

Background

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
REIC gene therapy (Momotaro-Gene) MTG-201; Ad5-SGE-REIC/Dkk-3 Phase 2 Clinical Momotaro-Gene Mesothelioma; Prostatic Neoplasms Details
Ad-SGE-DKK3 gene therapy Ad-SGE-DKK3; Ad-SGE-REIC Phase 2 Clinical Kyorin Pharmaceutical Co Ltd Mesothelioma Details

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