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Dkk-3

Dkk-3 Molecule Information

Name:Dickkopf-related protein 3
Target Synonym:hDkk-3;REIC;Dickkopf-3;DKK3;Dkk-3
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
DK3-M5226 Mouse Mouse Dkk-3 Protein, His Tag
DK3-M5226-structure
DK3-M5226-sds
DK3-H5220 Human Human Dkk-3 Protein, His Tag
DK3-H5220-structure
DK3-H5220-sds

Dkk-3 Molecule Synonym Name

DKK3,REIC,RIG

Dkk-3 Molecule Background

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.

Dkk-3 References

Dkk-3 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
REIC gene therapy (Momotaro-Gene) Ad5-SGE-REIC/Dkk-3; MTG-201 Phase Ⅱ Momotaro-Gene, Icahn School of Medicine at Mount Sinai Pleural mesothelioma, Prostate cancer Details

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