Dkk-3
Dkk-3 Molecule Information
Name:Dickkopf-related protein 3
Target Synonym:hDkk-3;REIC;Dickkopf-3;DKK3;Dkk-3
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase ?
Dkk-3 Molecule Synonym Name
DKK3,REIC,RIG
Dkk-3 Molecule Background
Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.
Dkk-3 References
- Medinger M, Tzankov A,et al., 2011, Thromb Haemost. 105(1):72-80.
- Yue W, Sun Q, et al., 2008, Carcinogenesis. 29(1):84-92..
- Pinho S, Niehrs C.et al., 2007, Differentiation. 75(10):957-67.
Dkk-3 Clinical Drug Information
Name |
Research Code |
Research Phase |
Company |
Indications |
Clinical Trials |
REIC gene therapy (Momotaro-Gene) |
Ad5-SGE-REIC/Dkk-3; MTG-201 |
Phase Ⅱ |
Momotaro-Gene, Icahn School of Medicine at Mount Sinai |
Pleural mesothelioma, Prostate cancer |
Details
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