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Brief Information

Name:Ectonucleotide pyrophosphatase/phosphodiesterase 2
Target Synonym:E-NPP 2,Autotaxin,ENPP2,PDNP2,Ectonucleotide Pyrophosphatase/Phosphodiesterase 2,Extracellular Lysophospholipase D,LysoPLD,ATX,Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2,Phosphodiesterase I/Nucleotide Pyrophosphatase 2,Plasma Lysopho
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
EN2-H5241 Human Human ENPP-2 / Autotaxin Protein, His Tag (active enzyme)

Synonym Name



Autotaxin also known as ectonucleotide pyrophosphatase / phosphodiesterase family member 2 (E-NPP 2 or ENPP2), Extracellular lysophospholipase D (LysoPLD), Autotaxin (ATX or ATX-X), which belongs to the nucleotide pyrophosphatase / phosphodiesterase family. ENPP2 contains two SMB (somatomedin-B) domains. ENPP2 hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. ENPP2 can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. ENPP2 stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
BBT-877 BBT-877 Phase 1 Clinical Legochem Idiopathic Pulmonary Fibrosis Details
HNC664 HNC664; HNC-664 Phase 1 Clinical Guangzhou Henovcom Bioscience Co Ltd Idiopathic Pulmonary Fibrosis Details
BLD-0409 PAT-409; BLD-0409 Phase 1 Clinical Blade Therapeutics Non-alcoholic Fatty Liver Disease; Liver Diseases Details
Ziritaxestat GLPG-1690 Phase 2 Clinical Galapagos Nv Idiopathic Pulmonary Fibrosis; Scleroderma, Systemic Details

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