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APCS Molecule Information

Name:Serum amyloid P-component
Target Synonym:Serum amyloid P-component;9.5S alpha-1-glycoprotein;SAP;APCS;PTX2;Serum amyloid P-component(1-203)
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
APS-H5229 Human Human APCS / SAP / PTX2 Protein, His Tag

APCS Molecule Synonym Name

PTX2,APCS,SAMP,SAP,Pentraxin 2

APCS Molecule Background

Serum amyloid P-component (SAP) is also known as Pentraxin 2 (PTX2), APCS, which belongs to the pentaxin family. SAP contains one pentaxin domain. PTX2 is a secreted homopentamer protein which is found in serum and urine. SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. SAP can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. SAP may also function as a calcium-dependent lectin. SAP has certain sequence homology with C-reactive protein (CRP).

APCS References

APCS Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Miridesap GSK-2315698; GSK-2315698A; Ro-63-8695 Phase Ⅱ Roche, GlaxoSmithKline, Pentraxin Therapeutics Systemic amyloidosis Details
Dezamizumab GSK-2398852 Phase Ⅱ Pentraxin Therapeutics, GlaxoSmithKline Systemic amyloidosis Details
Miridesap/Dezamizumab GSK-2315698/GSK-2398852 Phase Ⅱ Pentraxin Therapeutics, GlaxoSmithKline Systemic amyloidosis Details
GSK-3039294 GSK-3039294 Phase Ⅰ GlaxoSmithKline Amyloid light chain amyloidosis (AL amyloidosis) Details

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