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Erythropoietin R

Erythropoietin R Molecule Information

Name:Erythropoietin receptor
Target Synonym:EPOR;Erythropoietin receptor;EPO-R
Number of Launched Drugs:76
Number of Drugs in Clinical Trials:57
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
EPR-H5253 Human Human Erythropoietin R / EPO R Protein, Fc Tag
EPR-H5253-structure

Erythropoietin R Molecule Synonym Name

EPOR

Erythropoietin R Molecule Background

Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis , and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage. EPOR is a type 1 single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers. EPOR pre-exists as dimers which upon binding of a 34 kDa ligand erythropoietin (Epo), changes its homodimerized state. These conformational changes result in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor. Erythropoietin is necessary to maintain endothelial cells and to promote tumor angiogenesis, hence the dysregulation of EpoR may affect the growth of certain tumors. EpoR signaling prevents neuronal death and ischemic injury.

Erythropoietin R References

Erythropoietin R Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Epoetin beta biosimilar (Veropharm) Approved Abbott Anemia Details
Erythropoietin biosimilar (Fresenius Kabi Oncology) Approved Fresenius Kabi Anemia Details
Recombinant human erythropoietin (Daying Pharma) Approved Daying Pharmaceutical Anemia Details
Erythropoietin biosimilar (Landsteiner Scientific) Approved Landsteiner Scientific Anemia Details
Epoetin alfa biosimilar (Wockhardt) Approved Wockhardt Anemia Details
Epoetin alfa biosimilar (Sotex Farm Firm) Approved Protek Group Anemia Details
Epoetin alfa biosimilar (Sedico) Approved Sedico Chemotherapy-induced anaemia, Anemia Details
Methoxy polyethylene glycol-epoetin beta RO-0503821 ; Ro-50-3821; CERA; R-1744; R-744; RG-744,Ro503821 Approved Roche, Chugai, Galenica Methoxy polyethylene glycol-epoetin beta ema

Treatment of symptomatic anaemia associated with chronic kidney disease (CKD).

The safety and efficacy of Mircera therapy in other indications has not been established.

Roche Registration GmbH 2007-07-20 Anemia Details
Erythropoietin biosimilar (Unilab/Biomedis) Approved Unilab, Biomedis Anemia Details
Epoetin alfa KRN-5702,KRN5702 Approved Amgen, Janssen, Kyowa Hakko Kirin EPOGEN/PROCRIT fda Allogeneic RBC transfusion, Anemia AMGEN 1989-06-01 Allogeneic RBC transfusion, Anemia Details
Epoetin beta BM-06.019; BM-06019; RO-205-3859 Approved Roche, Chugai, Eddingpharm Recormon hma Anemia Boehringer Mannheim GmbH
Sandhofer Str. 116
D-68305 Mannheim
1996-03-05 Anemia Details
Erythropoietin biosimilar (RPG Life Sciences) Approved RPG Life Sciences Anemia Details
Recombinant erythropoietin biosimilar (Lupin) Approved Lupin Anemia Details
Recombinant erythropoietin (Cadila Pharmaceuticals) Approved Cadila Anemia Details
Recombinant human erythropoietin biosimilar (North China Pharmaceutical Corporation) Approved North China Pharmaceutical Corporation Recombinant Human Erythropoietin Injection(CHO Cell) cfda Anemia 2015-09-01 Anemia Details
Recombinant erythropoietin biosimilar (Elea) Approved Elea Anemia Details
Epoetin alfa biosimilar (Claris Lifesciences) Approved Claris Lifesciences Anemia Details
Erythropoietin (Dong-A ST) DA-3285 Approved Dong-A Pharmaceutical, Dem Ilac Anemia Details
Recombinant Human Erythropoietin Injection (Shenzhen Saibaoer) Approved Shenzhen Saibaoer Biological Pharmaceutical Anaemia Details
Erythropoietin biosimilar (Shantha Biotechnics) Approved Shantha Biotechnics Anemia Details
Epoetin alfa biosimilar (Sun Pharmaceutical Industires) Approved Ranbaxy Laboratories, Sun Pharmaceutical Anemia Details
Erythropoietin biosimilar (Neiss Labs) Approved Neiss Labs Anemia Details
Erythropoietin biosimilar (Sudershan Biotech) Approved Sudershan Biotech Ltd Anemia Details
Erythropoietin biosimilar (Incepta Pharmaceuticals) Approved Incepta Pharmaceuticals Anemia Details
Epoetin alfa biosimilar (PT Kalbe) Approved Kalbe Farma Chronic Renal Anemia, Chemotherapy-induced anaemia Details
Erythropoietin biosimilar (Klarvoyant Biogenics) Approved Klarvoyant Anemia Details
Epoetin alfa biosimilar (CJ Corp) Approved CJ, RG Pharmaceutica, Macropharma Anemia Details
Recombinant human erythropoietin alfa (Daewoong Pharmaceutical) DWP-413,DWP 413,DWP413 Approved Daewoong Anemia Details
Recombinant erythropoietin long-acting (Shandong Kexing Bioproducts) Approved Shandong Kexing Bioproducts Co., Ltd Anemia Details
Epoetin omega HP-EPO-CRF Approved Elanex Pharma Group Anemia Details
Erythropoietin biosimilar (Micro Labs) Approved Micro Labs Anemia Details
Darbepoetin alfa biosimilar (Dr Reddy's) Approved Dr Reddys Laboratories Anemia Details
Recombinant human erythropoietin (Center of Molecular Immunology) Approved Center of molecular immunology Aplastic anaemia Details
Epoetin alfa biosimilar (Biosidus) Approved Biosidus Anemia Details
Erythropoietin biosimilar (VHB Life Sciences) Approved VHB Life Sciences Anemia Details
Erythropoietin biosimilar (Center for Genetic Engineering and Biotechnology) Approved Center for Genetic Engineering and Biotechnology Anemia Details
Darbepoetin alfa biosimilar (Torrent) Approved Torrent Pharmaceuticals Anemia Details
Recombinant human erythropoietin (Shenzhen Xinpeng Bio-tech) Approved Shenzhen Xinpeng Biological Engineering Recombinant Human Erythropoietin Injection(CHO Cell) cfda Anemia 2015-09-08 Anemia Details
Epoetin alfa biosimilar (Dragon Pharmaceutical) BR-05001 Approved Dragon Anemia Details
Epoetin alfa biosimilar (Emcure) Approved Emcure Anemia Details
Epoetin beta biosimilar (Microgen) Approved Microgen State Scientific Industrial Anemia Details
Epoetin zeta SB-309 Approved BIOCEUTICALS Arzneimittel, Hospira, STADA Arzneimittel epoetin zeta ema Stada Arzneimittel AG 2007-12-18 Anemia Details
Recombinant human erythropoietin (CHO Cell), Harbin Pharmaceutical Group Bioengineering Approved Harbin Pharmaceutical Group Anemia Details
Epoetin alfa biosimilar (Laboratorios AC Farma) Approved Laboratorios AC Farma Anemia Details
Erythropoietin biosimilar (Chalver Laboratorios) Approved Chalver Laboratorios Anemia Details
Recombinant human erythropoietin (3SBio/Biolotus) Approved 3SBio, Biolotus Chemotherapy-induced anaemia Details
Epoetin alfa biosimilar (Probiomed) Approved Probiomed Anemia Details
Recombinant human erythropoietin (Beijing Four Rings Bio-Pharmaceutical) Approved Beijing Four Rings Biopharmaceutical Anemia Details
Darbepoetin alfa biosimilar (Hetero Drugs) Approved Hetero Drugs Anemia Details
Darbepoetin alfa biosimilar (Kyowa Hakko Kirin) Approved Kyowa Hakko Kirin Darbepoetin alfa biosimilar (Kyowa Hakko Kirin) 日本 Anaemia 协和发酵麒麟 2018-08-15 00:00:00.0 Anaemia, Anemia Details
Epoetin beta biosimilar (CinnaGen) Approved CinnaGen Anemia Details
Epoetin theta Approved Teva epoetin theta ema Teva GmbH 2009-10-23 Anemia Details
Epoetin alfa biosimilar (Biocon) Approved Biocon BioPharmaceuticals Anemia Details
Epoetin alfa biosimilar (LG Life Sciences) Approved LG Life Sciences Anemia Details
Epoetin alfa biosimilar (Siam Bioscience) Approved Siam Bioscience Anemia Details
Recombinant erythropoietin biosimilar (Recpharma) Approved ReceptoPharm Anemia Details
Epoetin alfa biosimilar (Laboratorios Bioprofarma) Approved Laboratorios Bioprofarma Anemia Details
Epoetin alfa biosimilar (Sandoz) HX-575 Approved Sandoz, Medice Arzneimittel, Hexal epoetin alfa ema Hexal AG 2007-08-27 Anemia Details
Epoetin alfa biosimilar (Laboratorio Varifarma) Approved Laboratorio Varifarma Anemia Details
Recombinant human erythropoietin (Chengdu Diao Group) Approved Chengdu Diao Group Anemia Details
Darbepoetin alfa (Amgen) Epo-N47; KRN-321; N-47 Approved Amgen, Kyowa Hakko Kirin, Dompe Farmaceutici darbepoetin alfa ema Amgen Europe B.V. 2001-06-08 Anemia Details
Epoetin beta biosimilar (Pharmapark) Approved Pharmapark Anemia Details
Erythropoietin biosimilar (Zuventus Healthcare) Approved Zuventus Healthcare Anemia Details
Epoetin alfa biosimilar (Intas BioPharmaceuticals) Approved Intas Biopharmaceuticals Anemia Details
Epoetin biosimilar (Zydus Cadila) Approved Zydus cadila Anemia Details
Epoetin alfa biosimilar (Amega Bitoech) Approved Amega Biotech Anemia Details
Epoetin alfa biosimilar (Nanogen) Approved Nanogen Biopharmaceutical Co Anemia Details
Human erythropoietin biosimilar (Celon Laboratories) Approved Celon Laboratories Anemia Details
Epoetin alfa biosimilar (Reliance Life Sciences) Approved GeneMedix Plc, Reliance Life Sciences, Stragen Pharma Anemia Details
Recombinant erythropoietin (Shanghai Chemo Wanbang Biopharma) Approved Shanghai ChemoWanbang Biopharma Anemia Details
Epoetin kappa (JCR Pharmaceuticals) JR-013,JR013 Approved JCR Pharmaceuticals, Kissei Epoetin kappa (JCR Pharmaceuticals) 日本 Anemia JCR Pharmaceuticals 2010-01-20 00:00:00.0 Anemia Details
Erythropoietin biosimilar (Genius Biotherapeutics) Approved Genius Biotherapeutics Anemia Details
Recombinant human erythropoietin (Shandong Ahua Biochemical) Approved Shandong Ahua Biochemical Anemia Details
Epoetin alfa biosimilar (Blau Farmaceutica) Approved Blau Farmaceutica Anemia Details
Epoetin alfa (Pooyesh Darou Pharmaceuticals) Approved Pooyesh Darou Anemia Details
Epoetin alfa biosimilar (Fiocruz/Bio-Manguinhos) Approved Fundacao Oswaldo Cruz (FIOCRUZ) Anemia Details

Erythropoietin R Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Epoetin alfa biosimilar (Apotex) APO-EPO Phase Ⅲ Apotex Anemia Details
CKD-11101 CKD-11101 Phase Ⅲ Chong Kun Dang Anaemia Details
Recombinant human erythropoietin (Max Planck Institute) Phase Ⅱ Max Planck Institute of Experimental Medicine Schizophrenia, Multiple sclerosis (MS) Details
Erythropoietin (Epoplus) Phase Ⅰ Cytonet wound, Renal failure Details
Recombinant human erythropoietin-Fc fusion protein (Dongguan baolijian Biotech) Phase Ⅰ Dongguan baolijian biotech Anemia Details
Recombinant erythropoietin (Prolong Pharmaceuticals/Zydus Cadila) ZY-7318 Phase Ⅰ Prolong Pharmaceuticals, Zydus cadila Anemia Details
Recombinant human erythropoietin (Hanyang University Seoul Hospital) Phase Ⅱ Hanyang University Amyotrophic lateral sclerosis (ALS) Details
Epoetin alfa biosimilar (UBI Pharma) UB-851 Phase Ⅲ United Biomedical Anaemia Details
Erythropoietin (Y-shaped pegylation, Xiamen Amoytop Biotech) Phase Ⅰ Xiamen Amoytop Biotech, BioGeneric Anemia Details
Long-acting erythropoietin (Teva) Preclinical CSL Behring, Teva Anemia Details
R-1516 R-1516 Phase Ⅰ Gryphon Therapeutics, Roche Anemia Details
Peginesatide acetate AF-37702; Peptidic ERA Withdrawn Affymax, Takeda Anemia Details
LU AA 24493 Lu-AA24493 Phase Ⅱ Warren Pharmaceuticals, Lundbeck Friedreich's ataxia, Stroke Details
CNTO528 CNTO-528; CNTO 528; CNTO528 Phase Ⅰ Centocor, Janssen, Johnson & Johnson Anemia Details
rhEPO-Fc (Shanghai Meiye Biotechnology) Phase Ⅰ Shanghai meiye Biotech Anemia Details
Pegylated recombinant human erythropoietin (Shenzen Saibaoer Biotech) Phase Ⅰ Shenzhen Saibaoer Biological Pharmaceutical Chronic Renal Anemia Details
Erythropoietin (Neose) NE-180 Phase Ⅱ Neose Technologies Anemia Details
Darbepoetin alfa biosimilar (Biocad) BCD-066 Phase Ⅲ Biocad Anemia Details
Erythropoietin biosimilar (AXXO) Phase Not Specified AXXO Chemotherapy-induced anaemia Details
Darbepoetin alfa biosimilar (AvesthaGen) Phase Ⅲ Avesthagen, QuintilesIMS Anemia Details
Recombinant human erythropoietin-Fc fusion protein (Shanhai meiye Biotech) Phase Ⅱ Shanghai meiye Biotech Anemia Details
Recombinant human erythropoietin (Uni-Bio Science Group) Phase Ⅰ Uni-Bio Science Group Anemia Details
Albumin-erythropoietin fusion protein (Tianjin SinoBiotech) Phase Ⅰ Tianjin SinoBiotech Anemia Details
GX-E2 EPO-hFC; EPO-hybrid-Fc; EPO-hyFc; GC-1113; GX-E2 Phase Ⅱ Genexine, Green Cross, Shanghai ChemoWanbang Biopharma Anemia Details
PEGylated erythropoietin (Intas Biopharmaceuticals) Phase Ⅲ Intas Biopharmaceuticals Anemia Details
NTx-488 NTx-488 Preclinical Trillium Therapeutics Inc Multiple sclerosis (MS) Details
Recombinant human erythropoietin-CTP fusion protein (Harbin Pharmaceutical) Phase Ⅰ Harbin Pharmaceutical Group Anemia Details
Recombinant human erythropoietin-Fc fusion protein (Dongguan Baolijian Bioengineer) Phase Ⅰ Dongguan baolijian biotech Anemia Details
Pegylated darbepoetin beta BCD-131 Phase Ⅱ Biocad Anemia Details
Recombinant human erythropoietin (Snow Brand Milk Products) Phase Ⅲ Snow Brand Milk Products Haematological disorders Details
Epoetin delta (Shire) MDL-104396; HMR-4396 Withdrawn Shire, Sanofi Renal failure, Anemia Details
Recombinant erythropoietin (Syntonix) Phase Ⅰ Biogen Idec Anemia Details
Epoetin alfa biosimilar (PanGen Biotech) PDA-10 Phase Ⅲ PanGen Biotech Anemia Details
Darbepoetin alfa biosimilar (CJ Healthcare) CJ-40001; YLB-217 Phase Ⅱ CJ CheilJedang, North China Pharmaceutical Corporation Anemia Details
Recombinant human erythropoietin (Shanghai Huaxin) IND Filing Shanghai Hua Xin High Biotechnology Inc Anaemia Details
Pegylated darbepoetin alfa biosimilar (Merck & Co.) MK-2578 Phase Ⅱ Merck Sharp & Dohme Anemia Details
MDGN-201 MDGN-201 Phase Ⅱ Aevi Genomic Medicine Anemia Details
LKA-651 LKA-651; LKA651 Phase Ⅱ Alcon, MorphoSys Diabetic macular edema Details
Darbepoetin alfa biosimilar (Nichi-Iko Pharmaceutical/Aprogen) AP-032 Preclinical Aprogen, Nichi-Iko Pharmaceutical Anemia Details
Darbepoetin alfa biosimilar (PanPharmaceuticals) Phase Not Specified PanPharmaceuticals Anemia Details
Recombinant erythropoietin stimulating protein (3SBio) Phase Ⅰ 3SBio Chronic Renal Failure Details
Pegol-Sihematide EPO-018B Phase Ⅲ Hansoh Pharma Anemia, Chronic kidney disease Details
Recombinant erythropoietin (Bio-Ker) Phase Not Specified Bio-Ker Unspecified Details
Darbepoetin alfa biosimilar (JCR Pharmaceuticals/Kissei Pharmaceutical) JR-131 BLA Filing Kissei, JCR Pharmaceuticals Anemia Details
Erythropoietin long-acting (Hanmi) HM-10760A; LAPS-EPO,HM 10760A; LAPS EPO,HM10760A Phase Ⅰ Hanmi Anemia Details
Recombinant erythropoietin (XTL) EPO-XTL; rHuEPO-XTL Phase Ⅰ Bio-GAL, XTL Biopharmaceuticals Multiple myeloma (MM) Details
Erythropoietin polysialic (Xenetic Biosciences) PSA-EPO; SYN-20070131RU Phase Ⅲ Lipoxen Technologies, Serum Institute of India, Xenetic Biosciences, SynBio Anemia Details
Novel erythropoiesis stimulant (Centergene) Phase Ⅰ Centergene Pharmaceuticals, Suzhou Kangju Biotechnology Co., Ltd., Shanghai Qiangbang Biotechnology Co., Ltd. Anemia Details
Erythropoietin biosimilar (Pooyesh Darou) Phase Ⅱ Pooyesh Darou Anemia Details
Erythropoietin receptor agonist (Biocad) Phase Ⅰ Biocad, Ligand Haematological disorders Details
Recombinant erythropoietin fusion protein (Merck Serono) Phase Ⅰ Merck Serono Anemia Details
Erythropoietin biobetter (Nautilus/HanAll) HL-033 Phase Ⅰ Nautilus Biotech, HanAll Anemia Details
Epoetin alfa biosimilar (Biocad) Phase Ⅰ Biocad Anemia Details
Darbepoetin alfa biosimilar (Reliance Life Sciences) RTPR-026; R-TPR-026 Phase Ⅲ Reliance Life Sciences Anemia Details
Darbepoetin alfa biosimilar (Dong-A ST) DA-3880; GBS-011 BLA Filing Dong-A Pharmaceutical, Sanwa Kagaku Kenkyusho Anemia Details
Darbepoetin alfa biosimilar (3SBio) SSS-06 Phase Ⅱ 3SBio Anemia Details
Epoetin beta biosimilar (Biocad) Phase Ⅰ Biocad Anemia Details

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