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Your Position: Home > Erythropoietin R

Erythropoietin R

Brief Information

Name:Erythropoietin receptor
Target Synonym:EPOR,Erythropoietin Receptor,EPO-R,Receptors, Erythropoietin,Truncated Erythropoietin Receptor
Number of Launched Drugs:79
Number of Drugs in Clinical Trials:29
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
EPR-H5253 Human Human Erythropoietin R / EPO R Protein, Fc Tag
EPR-H5253-structure

Synonym Name

EPOR

Background

Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis , and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage. EPOR is a type 1 single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers. EPOR pre-exists as dimers which upon binding of a 34 kDa ligand erythropoietin (Epo), changes its homodimerized state. These conformational changes result in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor. Erythropoietin is necessary to maintain endothelial cells and to promote tumor angiogenesis, hence the dysregulation of EpoR may affect the growth of certain tumors. EpoR signaling prevents neuronal death and ischemic injury.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Epoetin alfa biosimilar (Amega Bitoech) Approved Amega Biotech Anemia Details
Erythropoietin biosimilar (RPG Life Sciences) Approved Rpg Life Sciences Anemia Rpg Life Sciences 2011-01-01 Anemia Details
Erythropoietin biosimilar (Chalver Laboratorios) Approved Chalver Laboratorios Eritina Colombia Anemia Chalver Laboratorios 2012-10-01 Anemia Details
Erythropoietin (Dong-A ST) DA-3285 Approved Dong-A Pharmaceutical Co Ltd Eporon South Korea Anemia null 1999-01-01 Anemia Details
Recombinant erythropoietin biosimilar (Recpharma) Approved Receptopharm Epolyrec Iran Anemia Receptopharm 2015-01-01 Anemia Details
Erythropoietin biosimilar (Landsteiner Scientific) Approved Landsteiner Scientific Erlan Mexico Anemia Landsteiner Scientific 2012-08-01 Anemia Details
Epoetin alfa biosimilar (Blau Farmaceutica) Approved Blau Farmaceutica Eritromax Brazil Anemia Blau Farmaceutica 2012-01-01 Anemia Details
Epoetin alfa biosimilar (PT Kalbe) Approved Kalbe Farma Cambodia, Burma, Sri Lanka, Vietnam Anemia Kalbe Farma 2003-12-31 Anemia Details
Epoetin alfa biosimilar (Nanogen) Approved Nanogen Biopharmaceutical Co Nanokine Vietnam Anemia Nanogen Biopharmaceutical Co 2014-01-01 Anemia Details
Epoetin alfa biosimilar (Intas BioPharmaceuticals) Approved Intas Biopharmaceuticals Epofit, Erykine, Renocel Anemia Details
Epoetin alfa biosimilar (Sotex Farm Firm) Approved Protek Group Eralfon Anemia Details
Recombinant erythropoietin biosimilar (Elea) Approved Elea Pronivel Argentina Anemia Elea 2009-01-01 Anemia Details
Erythropoietin biosimilar (Shantha Biotechnics) Approved Shantha Biotechnics Shanpoietin India Anemia Shantha Biotechnics 2005-01-01 Anemia Details
Epoetin alfa biosimilar (CJ Corp) Approved Cj Epokine Anemia Details
Epoetin alfa biosimilar (Laboratorios AC Farma) Approved Laboratorios Ac Farma Proclat Anemia Details
Epoetin beta biosimilar (CinnaGen) Approved Cinnagen CinnaPoietin India Anemia Cinnagen 2013-01-01 Anemia Details
Epoetin alfa biosimilar (Claris Lifesciences) Approved Claris Lifesciences Epotin India Anemia Claris Lifesciences 2011-01-01 Anemia Details
Epoetin omega HP-EPO-CRF Approved Elanex Pharma Group Anemia Details
Erythropoietin biosimilar (Micro Labs) Approved Micro Labs India Anemia Micro Labs Ltd 2012-01-01 Anemia Details
Recombinant Human Erythropoietin Injection (Shenzhen Saibaoer) Approved Shenzhen Sciprogen Bio-Pharmaceutical Co Ltd 赛博尔 Mainland China Anemia Shenzhen Sciprogen Bio-Pharmaceutical Co Ltd 2001-01-01 Anemia Details
Erythropoietin biosimilar (Klarvoyant Biogenics) Approved Klarvoyant Epomine Anemia Details
Epoetin beta biosimilar (Pharmapark) Approved Pharmapark Anemia Pharmapark 2007-12-01 Anemia Details
Epoetin alfa biosimilar (Biocon) Approved Biocon Biopharmaceuticals Erypro India Anemia Biocon Biopharmaceuticals 2011-01-01 Anemia Details
Epoetin alfa biosimilar (Laboratorio Varifarma) Approved Laboratorio Varifarma Anemia Details
Human erythropoietin biosimilar (Celon Laboratories) Approved Celon Laboratories Celpoietin India Anemia Celon Laboratories 2012-01-01 Anemia Details
Recombinant erythropoietin (Shanghai Chemo Wanbang Biopharma) Approved Shanghai Chemo Wanbang Biophama Co Ltd Clonepo Mainland China Anemia Shanghai Chemo Wanbang Biophama Co Ltd 1998-01-01 Anemia Details
Erythropoietin biosimilar (Incepta Pharmaceuticals) Approved Incepta Pharmaceuticals Bangladesh Anemia Incepta Pharmaceuticals 2012-08-01 Anemia Details
Erythropoietin biosimilar (Unilab/Biomedis) Approved Unilab, Biomedis Renogen Anemia Details
Epoetin alfa biosimilar (Wockhardt) Approved Wockhardt Wepox Anemia Details
Epoetin alfa biosimilar (Sun Pharmaceutical Industires) Approved Ranbaxy Laboratories Ceriton Anemia Details
Darbepoetin alfa biosimilar (Torrent) Approved Torrent Pharmaceuticals Darbatitor Anemia Details
Epoetin alfa biosimilar (Emcure) Approved Emcure Epofer Anemia Details
Recombinant human erythropoietin (CHO Cell), Harbin Pharmaceutical Group Bioengineering Approved Harbin Pharmaceutical Group Holding Co Ltd 雪达升 Mainland China Anemia Harbin Pharmaceutical Group 2005-10-19 Anemia Details
Darbepoetin alfa biosimilar (Hetero Drugs) Approved Hetero Drugs Actorise Anemia Details
Recombinant human erythropoietin (Shenzhen Xinpeng Bio-tech) Approved Shenzhen Xinpeng Biology Engineering Co Ltd 依博 Mainland China Anemia Shenzhen Sinobioway Xinpeng Biomedicine Co Ltd 2005-03-29 Anemia Details
Erythropoietin biosimilar (VHB Life Sciences) Approved Vhb Life Sciences Epotop India Anemia Vhb Life Sciences 2012-01-01 Anemia Details
Epoetin alfa biosimilar (Siam Bioscience) Approved Siam Bioscience Hema-Plus Thailand Anemia Siam Bioscience 2017-11-01 Anemia Details
Epoetin alfa biosimilar (Laboratorios Bioprofarma) Approved Laboratorios Bioprofarma Anemia Details
Epoetin alfa biosimilar (Fiocruz/Bio-Manguinhos) Approved Fundacao Oswaldo Cruz (Fiocruz) Brazil Anemia Fundacao Oswaldo Cruz (Fiocruz) 2006-12-01 Anemia Details
Epoetin alfa biosimilar (Sedico) Approved Sedico Anemia Details
Recombinant human erythropoietin (Daying Pharma) Approved Daying Pharmaceutical 诺之素 Mainland China Anemia Daying Pharmaceutical 2002-05-09 Anemia Details
Epoetin alfa biosimilar (Dragon Pharmaceutical) BR-05001 Approved Dragon Anemia Details
Erythropoietin biosimilar (Zuventus Healthcare) Approved Zuventus Healthcare Eporise India Anemia Zuventus Healthcare 2012-08-01 Anemia Details
Epoetin theta Approved Teva Pharmaceutical Industries Ltd Biopoin, Eporatio EU Kidney Failure, Chronic; Anemia Teva Gmbh 2009-10-23 Anemia; Kidney Failure, Chronic Details
Recombinant human erythropoietin (3SBio/Biolotus) Approved Shenyang Sunshine Pharmaceutical Co Ltd, Biolotus EPIAO Mainland China Anemia Shenyang Sunshine Pharmaceutical Co Ltd 1998-01-01 Anemia Details
Epoetin alfa biosimilar (Biosidus) Approved Biosidus Hemax, Hypercrit Anemia Details
Recombinant erythropoietin (Cadila Pharmaceuticals) Approved Cadila Pharmaceuticals Cadicrit Anemia Details
Recombinant erythropoietin long-acting (Shandong Kexing Bioproducts) Approved Shandong Kexing Bio-Products Co Ltd Eposino, Yipuding Mainland China Anemia Shandong Kexing Bio-Products Co Ltd 2000-01-01 Anemia Details
Erythropoietin biosimilar (Neiss Labs) Approved Neiss Labs India Anemia Neiss Labs 2012-08-01 Anemia Details
Epoetin beta biosimilar (Microgen) Approved Microgen State Scientific Industrial Erythrostim Russian Federation Anemia Microgen State Scientific Industrial 2012-01-01 Anemia Details
Erythropoietin biosimilar (Center for Genetic Engineering and Biotechnology) Approved Center For Genetic Engineering And Biotechnology Heberitro Anemia Details
Epoetin alfa biosimilar (Probiomed) Approved Probiomed Bioyetin Mexico Anemia Probiomed 2006-03-01 Anemia Details
Recombinant human erythropoietin (Center of Molecular Immunology) Approved Center Of Molecular Immunology Ior Cuba Anemia, Aplastic Center Of Molecular Immunology 1998-04-01 Anemia, Aplastic Details
Recombinant erythropoietin biosimilar (Lupin) Approved Lupin Epocept India Anemia Rubin Ltd 2011-01-01 Anemia Details
Epoetin alfa biosimilar (Reliance Life Sciences) Approved Genemedix Plc Epostim, ReliPoietin Anemia Details
Recombinant human erythropoietin alfa (Daewoong Pharmaceutical) DWP-413 Approved Daewoong Pharmaceutical Co Ltd Eposis South Korea Anemia Daewoong Pharmaceutical Co Ltd 2007-12-01 Anemia Details
Erythropoietin biosimilar (Genius Biotherapeutics) Approved Genius Biotherapeutics Repotin South Africa Anemia Genius Biotherapeutics 1998-12-01 Anemia Details
Epoetin alfa (Pooyesh Darou Pharmaceuticals) Approved Pooyesh Darou Iran Anemia Pooyesh Darou 2009-01-01 Anemia Details
Epoetin biosimilar (Zydus Cadila) Approved Zydus Cadila Anemia Details
Epoetin beta biosimilar (Veropharm) Approved Abbott Laoratories Vero-epoetin Anemia Details
Erythropoietin biosimilar (Sudershan Biotech) Approved Sudershan Biotech Ltd Epovin India Anemia Sudershan Biotech Ltd 2012-01-01 Anemia Details
CKD-11101 CKD-11101 Approved Chong Kun Dang Pharmaceutical Corp Anemia Details
Erythropoietin biosimilar (Fresenius Kabi Oncology) Approved Fresenius Kabi Ag Anemia Details
Darbepoetin alfa biosimilar (Dr Reddy's) Approved Dr. Reddy’S Laboratories Ltd Cresp Anemia Details
Recombinant human erythropoietin biosimilar (North China Pharmaceutical Corporation) Approved North China Pharmaceutical Company Ltd 济脉欣 Mainland China Anemia Ncpc Genetech Biotechnology Co Ltd 2000-01-01 Anemia Details
Recombinant human erythropoietin (Beijing Four Rings Bio-Pharmaceutical) Approved Beijing Four Rings Bio-Pharmaceutical Co Ltd 环尔博 Mainland China Anemia Beijing Four Rings Bio-Pharmaceutical Co Ltd 2000-01-01 Anemia Details
Darbepoetin alfa biosimilar (Kyowa Hakko Kirin) Approved Kyowa Hakko Kirin Co Ltd Japan Anemia Kyowa Hakko Kirin Co Ltd 2018-08-15 Anemia Details
Epoetin alfa biosimilar (LG Life Sciences) Approved Lg Life Sciences Ltd Espogen Mainland China Anemia Lg Life Sciences Ltd 2017-01-01 Anemia Details
Recombinant human erythropoietin (Chengdu Diao Group) Approved Chengdu Di'Ao Pharmaceutical Group Co Ltd 依倍 Anemia Details
Darbepoetin alfa biosimilar (Dong-A ST) DA-3880; GBS-011 Approved Dong-A Pharmaceutical Co Ltd Japan Anemia Sanwa Kagaku Kenkyusho Co Ltd 2019-09-20 Anemia Details
Darbepoetin alfa biosimilar (JCR Pharmaceuticals/Kissei Pharmaceutical) JR-131 Approved Kissei Pharmaceutical Co Ltd, Jcr Pharmaceuticals Japan Anemia Jcr Pharmaceuticals 2019-09-20 Anemia Details
Recombinant human erythropoietin (China Resources Angde Biotech Pharma) Approved China Resources Angde Biotech Pharma Co Ltd 佳林豪 Mainland China Anemia China Resources Angde Biotech Pharma Co Ltd 2003-01-01 Anemia Details
Recombinant erythropoietin (Shanxi Weiqidaguangming) Approved Shanxiweiqidaguangming Pharmaceutical Co Ltd Cadicrit Mainland China Anemia Shanxi Weiqidaguangming Pharmaceutical Co Ltd 1998-01-01 Anemia Details
Methoxy polyethylene glycol-epoetin beta R-1744; RG-744; RO-0503821; CERA; Ro-50-3821; R-744 Approved F. Hoffmann-La Roche Ltd Mircera Mainland China Anemia Roche Pharma (Schweiz) Ag 2007-07-20 Anemia; Renal Insufficiency, Chronic; Kidney Failure, Chronic Details
Epoetin beta BM-06019; BM-06.019; RO-205-3859 Approved F. Hoffmann-La Roche Ltd NeoRecormon/Epogin, Epogin, Marogen, Recormon, NeoRecormon Mainland China Anemia Roche Pharma (Switzerland) Ltd 1997-07-16 Anemia; Kidney Failure, Chronic; Immunologic Deficiency Syndromes Details
Recombinant Human Erythropoietin β (CHO Cell)(Shanghai Roche) Approved Shanghai Roche Pharmaceuticals Ltd 罗可曼® Recormon® Details
Epoetin alfa KRN-5702 Approved Amgen Inc, Janssen Global Services Llc Espo, Eprex, Erypo, Epoade, Epogen, Epopen, Procrit, Procrit/Eprex, 利血宝, Globuren Mainland China Anemia Kyowa Hakko Kirin China Pharmaceutical Co Ltd 1989-06-01 Hodgkin Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Kidney Failure, Chronic; Neoplasm Metastasis; Heart Arrest; Lymphoma, Non-Hodgkin; Venous Thrombosis; Lymphoma; Renal Insufficiency, Chronic; Prostatic Neoplasms; Transfusion Reaction; Critical Illness; Breast Neoplasms; Multiple Myeloma; Hypertrophy, Left Ventricular; Stroke; Ovarian Neoplasms; Arthritis, Rheumatoid; Small Cell Lung Carcinoma; Kidney Diseases; Myelodysplastic Syndromes; Leukemia, Lymphoid; Rectal Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Renal Insufficiency; Carcinoma; Anemia; Leukemia; Acquired Immunodeficiency Syndrome; HIV Infections Details
Epoetin kappa biosimilar (JCR Pharmaceuticals) JR-013 Approved Jcr Pharmaceuticals Japan Anemia Jcr Pharmaceuticals 2010-01-20 Anemia Details
Darbepoetin alfa (Amgen) KRN-321; N-47; Epo-N47 Approved Amgen Inc Aranesp, Nesp, Nespo, 耐斯宝 Mainland China Anemia Kyowa Hakko Kirin 2001-06-08 Multiple Myeloma; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Non-Small-Cell Lung; Kidney Failure, Chronic; Lymphoma; Renal Insufficiency, Chronic; Lung Neoplasms; Ventricular Dysfunction; Breast Neoplasms; Solid tumours; Myeloproliferative Disorders; Small Cell Lung Carcinoma; Myelodysplastic Syndromes; Kidney Diseases; Carcinoma; Heart Failure; Anemia Details
Epoetin alfa biosimilar (Sandoz) HX-575 Approved Sandoz Abseamed, Binocrit, Epoetin Alfa Hexal EU Anemia; Kidney Failure, Chronic Hexal Ag 2007-08-27 Anemia; Renal Insufficiency, Chronic; Kidney Failure, Chronic Details
Epoetin zeta SB-309 Approved Bioceuticals Arzneimittel Silapo, Retacrit United States Anemia Hospira Inc 2007-12-18 Anemia; Cardio-Renal Syndrome; Renal Insufficiency, Chronic; Kidney Failure, Chronic Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Recombinant human erythropoietin-Fc fusion protein (Dongguan Baolijian Bioengineer) Phase 1 Clinical Dongguan Baolijian Bioengineering Research And Development Co Ltd Anemia Details
Darbepoetin alfa biosimilar (3SBio) Phase 2 Clinical Shenyang Sunshine Pharmaceutical Co Ltd Anemia Details
Epoetin alfa biosimilar (Apotex) APO-EPO Phase 3 Clinical Apotex Anemia Details
Recombinant human erythropoietin (Hanyang University Seoul Hospital) Phase 2 Clinical Hanyang University Amyotrophic Lateral Sclerosis Details
Darbepoetin alfa biosimilar (PanPharmaceuticals) Clinical Panpharmaceuticals Anemia Details
Darbepoetin alfa biosimilar (Biocad) BCD-066 Phase 3 Clinical Biocad Anemia; Renal Insufficiency, Chronic; Kidney Failure, Chronic Details
Cibinetide pHBSP; ARA-290; 9W5677JKDA Phase 2 Clinical Araim Depression; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diabetic macular oedema; Neuralgia; Ischemia Details
Recombinant erythropoietin (Prolong Pharmaceuticals/Zydus Cadila) ZY-7318 Phase 1 Clinical Prolong Pharmaceuticals, Zydus Cadila Anemia Details
Epoetin alfa biosimilar (PanGen Biotech) PDA-10 Phase 3 Clinical Pangen Biotech Anemia Details
Recombinant human erythropoietin-CTP fusion protein (Harbin Pharmaceutical) Phase 1 Clinical Harbin Pharmaceutical Group Holding Co Ltd Anemia Details
Recombinant human erythropoietin (CHO Cell), Shanghai Chemo Wanbang Biophama Co Ltd Shanghai Chemo Wanbang Biophama Co Ltd Details
Darbepoetin alfa biosimilar (Reliance Life Sciences) RTPR-026; R-TPR-026 Phase 3 Clinical Reliance Life Sciences Anemia Details
rhEPO-Fc (Shanghai Meiye Biotechnology) Phase 1 Clinical Shanghai Meiye Biotechnology Co Ltd Anemia Details
Erythropoietin (Neose) NE-180 Phase 2 Clinical Neose Technologies Anemia Details
Erythropoietin polysialic (Xenetic Biosciences) PSA-EPO; SYN-20070131RU Phase 3 Clinical Lipoxen Technologies, Serum Institute Of India Anemia Details
Erythropoietin biosimilar (Pooyesh Darou) Phase 2 Clinical Pooyesh Darou Anemia Details
Darbepoetin alfa biosimilar (CJ Healthcare) YLB-217; CJ-40001 Phase 2 Clinical Cj Cheiljedang Corp Anemia Details
Erythropoietin receptor agonist (Biocad) Phase 1 Clinical Ligand Pharmaceuticals Inc, Biocad Hematologic Diseases Details
Recombinant Peglated human erythropoietin(Angde ) Phase 1 Clinical China Resources Angde Biotech Pharma Co Ltd Anemia Details
Efepoetin alfa GX-E2; EPO-hFC; GC-1113; EPO-hyFc; EPO-hybrid-Fc Phase 3 Clinical Genexine Inc Renal Insufficiency; Anemia; Renal Insufficiency, Chronic Details
Recombinant human erythropoietin-Fc fusion protein (Shanhai meiye Biotech) Phase 3 Clinical Shanghai Meiye Biotechnology Co Ltd Anemia Details
Albumin-erythropoietin fusion protein (Tianjin SinoBiotech) Phase 1 Clinical Tianjin Puying Biotechnology Co Ltd Anemia Details
Pegol-Sihematide EPO-018B Phase 3 Clinical Jiangsu Hansoh Pharmaceutical Group Co Ltd Anemia; Myelodysplastic Syndromes; Renal Insufficiency, Chronic; Kidney Failure, Chronic Details
Recombinant human erythropoietin-Fc fusion protein (Dongguan baolijian Biotech) Phase 1 Clinical Dongguan Baolijian Bioengineering Research And Development Co Ltd, Dongguan Taili Biological Engineering Co Ltd Anemia Details
Pegylated recombinant human erythropoietin (Shenzen Saibaoer Biotech) Phase 2 Clinical Shenzhen Sciprogen Bio-Pharmaceutical Co Ltd Anemia Details
LKA-651 LKA651; LKA-651 Phase 2 Clinical Morphosys, Alcon Macular Edema; Diabetic macular oedema; Macular Degeneration; Retinal Vein Occlusion Details
Erythropoietin (Y-shaped pegylation, Xiamen Amoytop Biotech) YPEG-EPO; YPEG-rhEPO Phase 2 Clinical Xiamen Amoytop Biotech Co Ltd, Biogeneric Anemia; Idiopathic short stature; Renal Insufficiency; Growth Disorders; Renal Insufficiency, Chronic; Growth hormone deficiency Details
Novel erythropoiesis stimulant (Centergene) Phase 1 Clinical Shanghai Qiangbang Biological Technology Co Ltd, Suzhou Shengji Pharmaceutical Co Ltd, Suzhou Kangju Biotechnology Co Ltd Anemia Details
Recombinant erythropoietin stimulating protein (3SBio) Phase 2 Clinical Shenyang Sunshine Pharmaceutical Co Ltd Anemia; Nephrosis; Renal Insufficiency, Chronic; Kidney Failure, Chronic Details
RD-001 RD-001 Phase 1 Clinical Shenyang Sunshine Pharmaceutical Co Ltd Anemia; Renal Insufficiency, Chronic Details

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