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Your Position: Home > Erythropoietin R

Erythropoietin R

Brief Information

Name:Erythropoietin receptor
Target Synonym:EPOR,Erythropoietin Receptor,EPO-R,Receptors, Erythropoietin,Truncated Erythropoietin Receptor
Number of Launched Drugs:82
Number of Drugs in Clinical Trials:30
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
ERR-H5253 Human Human Erythropoietin R / EPO R Protein, Fc Tag (MALS verified)
ACRO Quality

Part of Bioactivity data

Erythropoietin R MALS images

The purity of Human Erythropoietin R Protein, Fc Tag (Cat. No. ERR-H5253) is more than 85% and the molecular weight of this protein is around 100-120 kDa verified by SEC-MALS.

 Erythropoietin R ELISA

Immobilized Human EPO Protein, premium grade (Cat. No. EPO-H4214) at 10 μg/mL (100 μL/well) can bind Human Erythropoietin R Protein, Fc Tag (Cat. No. ERR-H5253) with a linear range of 0.6-10 ng/mL (QC tested).

Synonym Name



Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis , and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage. EPOR is a type 1 single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers. EPOR pre-exists as dimers which upon binding of a 34 kDa ligand erythropoietin (Epo), changes its homodimerized state. These conformational changes result in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor. Erythropoietin is necessary to maintain endothelial cells and to promote tumor angiogenesis, hence the dysregulation of EpoR may affect the growth of certain tumors. EpoR signaling prevents neuronal death and ischemic injury.

Clinical and Translational Updates

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