Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
user
  1. Dashboard
  2. My Profile
  3. My Address
  4. My Orders
  5. Acro Membership
Login Register
Recombinant Proteins ClearClear history
Recombinant Proteins CloseClose
Browse Products By Molecule Name a-zA-Z
TL1A Hot |GMP Cytokines Hot |FcRn Binding Kit (TR-FRET) New |Claudin 18.2
0
There is no goods in the shopping cart !
My Cart|Secure Checkout
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Erythropoietin R

Erythropoietin R

Brief Information

Name:Erythropoietin receptor
Target Synonym:EPOR,Erythropoietin Receptor,EPO-R,Receptors, Erythropoietin,Truncated Erythropoietin Receptor
Number of Launched Drugs:82
Number of Drugs in Clinical Trials:30
Lastest Research Phase:Approved

Product ListCompare or Buy

Product> Filter Results
By Product Status:
By Product Category:
By Species:
By Tag:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
ERR-C52H3 Cynomolgus Cynomolgus Erythropoietin R Protein, His Tag (MALS & SPR verified)
ERR-C52H3-structure
ERR-C52H3-sds
EPR-H52H4 Human Human Erythropoietin R / EPO R Protein, His Tag (MALS & SPR verified)
EPR-H52H4-structure
EPR-H52H4-sds
ERR-H5253 Human Human Erythropoietin R / EPO R Protein, Fc Tag (MALS verified)
ERR-H5253-structure
ERR-H5253-sds
ACRO Quality

Part of Bioactivity data

EPR-H52H4-Cell-based assay
Erythropoietin R CELL

Human Erythropoietin R Protein, His Tag (Cat. No. EPR-H52H4) inhibits human erythropoietin/EPO-dependent proliferation of TF-1 cells. The EC50 is 211.1 ng/mL (Routinely tested).

Protocol
ERR-C52H3-SPR
Erythropoietin R SPR

Cynomolgus Erythropoietin R Protein, His Tag (Cat. No. ERR-C52H3) immobilized on CM5 Chip can bind Human EPO Protein, premium grade (Cat. No. EPO-H4214) with an affinity constant of 0.613 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
EPR-H52H4-SPR
Erythropoietin R SPR

Human Erythropoietin R Protein, His Tag (Cat. No. EPR-H52H4) immobilized on CM5 Chip can bind Human EPO Protein, premium grade (Cat. No. EPO-H4214) with an affinity constant of 0.142 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol

Synonym Name

EPOR

Background

Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis , and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage. EPOR is a type 1 single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers. EPOR pre-exists as dimers which upon binding of a 34 kDa ligand erythropoietin (Epo), changes its homodimerized state. These conformational changes result in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor. Erythropoietin is necessary to maintain endothelial cells and to promote tumor angiogenesis, hence the dysregulation of EpoR may affect the growth of certain tumors. EpoR signaling prevents neuronal death and ischemic injury.

Clinical and Translational Updates

This web search service is supported by Google Inc.

totop
Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Email
Email
order@acrobiosystems.com
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA
linkedin twitter facebook youtube

Leave a message

Copyright © 2017 ACROBiosystems. All Rights Reserved
|Related Links|Privacy Policy|Terms and Conditions|Legal|Sitemap