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FABP6

FABP6 Molecule Information

Name:Bile acid binding protein
Target Synonym:ILLBP;Intestinal 15 kDa protein;I-BABP;FABP6;Fatty acid-binding protein 6;GT;ILBP;I-15P;Intestinal bile acid-binding protein
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
FA6-H5141 Human Human FABP6 Protein, His Tag
FA6-H5141-structure
FA6-H5141-sds

FABP6 Molecule Synonym Name

FABP6,ILBP,ILLBP,Gastrotropin,GT,I-15P,I-BABP,I-BALB,I-BAP

FABP6 Molecule Background

Fatty acid-binding protein 6 (FABP6), is also known as Intestinal bile acid-binding protein (I-BABP), Ileal lipid-binding protein (ILBP), Intestinal 15 kDa protein (I-15P), Gastrotropin (GT). FABP6 is a cytoplasm protein which belongs to the calycin superfamily and fatty-acid binding protein (FABP) family. Isoform 2 of FABP6 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 of FABP6 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Ileal protein FABP6 stimulates gastric acid and pepsinogen secretion. FABP6 seems to be able to bind to bile salts and bilirubins. Isoform 2 of FABP6 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.

FABP6 References

FABP6 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Colesevelam Hydrochloride GT31-104; GT31-104HB; GT-31104 Approved Genzyme, Daiichi Sankyo WELCHOL fda Heterozygous familial hypercholesterolemia, Type 2 diabetes, Primary hyperlipidemia DAIICHI SANKYO 2000-05-26 Heterozygous familial hypercholesterolemia, Hyperlipoproteinaemia type IIa, Type 2 diabetes, Primary hypercholesterolemia, Primary hyperlipidemia, Hypercholesterolemia, Familial hypercholesterolemia Details
Colestipol Hydrochloride Approved Pfizer COLESTID fda PHARMACIA UPJOHN 1977-04-04 Hyperlipidemia Details

FABP6 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SKF-97426 SKF-97426; SKF-97426A Phase Ⅱ GlaxoSmithKline Hypercholesterolemia Details
HBS-107 HBS-107 Phase Ⅱ Hisamitsu Pharmaceutical Hypercholesterolemia Details
Colesevelam (Ironwood) IW-3718 Phase Ⅲ Ironwood Gastroesophageal reflux disease (GERD) Details
GT-102279 GT102-279; GT-102-279; GT-102279 Phase Ⅱ Genzyme Hypercholesterolemia Details
BTG-511 BTG-511 Phase Ⅱ BTG plc Hypercholesterolemia Details
A-3384 A-3384 Phase Ⅱ Albireo Bile acid malabsorption (BAM) Details

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