Name:Bile acid binding protein Target Synonym:FABP6,GT,Fatty Acid-Binding Protein 6,I-BABP,Intestinal 15 KDa Protein,Fatty Acid Binding Protein 6, Ileal,Gastrotropin,Intestinal Bile Acid-Binding Protein,ILBP3,Ileal Bile Acid Binding Protein,ILBP,I-BAP,I-BALB,ILLBP,Illeal Lipid-Binding Protein,Ileal L
Number of Launched Drugs:2 Number of Drugs in Clinical Trials:2 Lastest Research Phase:Approved
Fatty acid-binding protein 6 (FABP6), is also known as Intestinal bile acid-binding protein (I-BABP), Ileal lipid-binding protein (ILBP), Intestinal 15 kDa protein (I-15P), Gastrotropin (GT). FABP6 is a cytoplasm protein which belongs to the calycin superfamily and fatty-acid binding protein (FABP) family. Isoform 2 of FABP6 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 of FABP6 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Ileal protein FABP6 stimulates gastric acid and pepsinogen secretion. FABP6 seems to be able to bind to bile salts and bilirubins. Isoform 2 of FABP6 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.