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FABP6

Brief Information

Name:Bile acid binding protein
Target Synonym:FABP6,GT,Fatty Acid-Binding Protein 6,I-BABP,Intestinal 15 KDa Protein,Fatty Acid Binding Protein 6, Ileal,Gastrotropin,Intestinal Bile Acid-Binding Protein,ILBP3,Ileal Bile Acid Binding Protein,ILBP,I-BAP,I-BALB,ILLBP,Illeal Lipid-Binding Protein,Ileal L
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

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By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
FA6-H5141 Human Human FABP6 Protein, His Tag
FA6-H5141-structure
FA6-H5141-sds

Synonym Name

FABP6,ILBP,ILLBP,Gastrotropin,GT,I-15P,I-BABP,I-BALB,I-BAP

Background

Fatty acid-binding protein 6 (FABP6), is also known as Intestinal bile acid-binding protein (I-BABP), Ileal lipid-binding protein (ILBP), Intestinal 15 kDa protein (I-15P), Gastrotropin (GT). FABP6 is a cytoplasm protein which belongs to the calycin superfamily and fatty-acid binding protein (FABP) family. Isoform 2 of FABP6 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 of FABP6 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Ileal protein FABP6 stimulates gastric acid and pepsinogen secretion. FABP6 seems to be able to bind to bile salts and bilirubins. Isoform 2 of FABP6 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Colestipol Hydrochloride Approved Pfizer Pharmaceuticals Ltd (China) Colestid United States Hyperlipidemias Pharmacia & Upjohn 1977-04-04 Hyperlipidemias Details
Colesevelam Hydrochloride GT31-104HB; GT-31104; GT31-104 Approved Genzyme Corp CholestaGel, Welchol, Colestagel EU Hypercholesterolemia Genzyme Europe Bv 2000-05-26 Diabetes Mellitus, Type 2; Hypercholesterolemia; Hyperlipoproteinemia Type II; Hyperlipidemias Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Colesevelam (Ironwood) IW-3718 Phase 3 Clinical Ironwood Gastroesophageal Reflux Details
A-3384 A-3384 Phase 2 Clinical Albireo Alagille Syndrome; Liver Cirrhosis, Biliary; Bile acid malabsorption (BAM); Liver Diseases; Progressive familial intrahepatic cholestasis; Malabsorption Syndromes Details

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