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Fas Molecule Information

Name:Apoptosis-mediating surface antigen FAS
Target Synonym:FASLG receptor;Apo-1 antigen;Apoptosis-mediating surface antigen FAS;APT1;Apoptosis antigen 1;CD95;TNFRSF6;FAS1;FAS
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
FAS-H5229 Human Human Fas / TNFRSF6 / CD95 Protein, His Tag
FAS-H5252 Human Human Fas / TNFRSF6 / CD95 Protein, Fc Tag

Fas Molecule Synonym Name


Fas Molecule Background

The Fas is also known as FAS receptor (FasR), apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6). is a death receptor on the surface of cells that leads to programmed cell death (apoptosis). It is one of two apoptosis pathways, the other being the mitochondrial pathway. FasR is located on chromosome 10 in humans and 19 in mice. Similar sequences related by evolution (orthologs) are found in most mammals. Fas forms the death-inducing signaling complex (DISC) upon ligand binding. Membrane-anchored Fas ligand trimer on the surface of an adjacent cell causes trimerization of Fas receptor. This event is also mimicked by binding of an agonistic Fas antibody, though some evidence suggests that the apoptotic signal induced by the antibody is unreliable in the study of Fas signaling. To this end, several clever ways of trimerizing the antibody for in vitro research have been employed.Upon ensuing death domain (DD) aggregation, the receptor complex is internalized via the cellular endosomal machinery. This allows the adaptor molecule FADD to bind the death domain of Fas through its own death domain. Recently, Fas has also been shown to promote tumor growth, since during tumor progression, it is frequently downregulated or cells are rendered apoptosis resistant. Cancer cells in general, regardless of their Fas apoptosis sensitivity, depend on constitutive activity of Fas. This is stimulated by cancer-produced Fas ligand for optimal growth.

Fas References

Fas Related Molecule

Fas Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
APO-010 APO-010 Phase Ⅱ Onxeo SA, Oncology Venture Solid tumours, Multiple myeloma (MM) Details
Anti-APO-1 monoclonal antibody DE-098; ARG-098 Phase Ⅱ Centocor, Johnson & Johnson, Santen, Argenes Rheumatoid arthritis (RA) Details
CTLA-4/FasL fusion protein (KAHR Medical) KAHR-102 IND Filing KAHR Medical Lymphoma Details

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