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Arginase 1

Brief Information

Name:Arginase-1
Target Synonym:Liver-type arginase,Type I arginase,ARG1,Arginase 1,Arginase, Liver,Arginase-1,EC 3.5.3.1,EC:3.5.3.1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
AR1-H5228 Human Human Arginase 1 / ARG1 Protein, His Tag
AR1-H5228-structure
AR1-H5228-sds

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Synonym Name

ARG1,Arginase-1

Background

Arginase-1 (ARG1) is also known as Liver-type arginase, Type I arginase, which belongs to the arginase family. Arginase-1 / ARG1 is a manganese-containing enzyme. The reaction catalyzed by this enzyme is: arginine + H2O ¡ú ornithine + urea. It is the final enzyme of the urea cycle. Defects in Arginase-1 / ARG1 are the cause of argininemia (ARGIN).

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Numidargistat INCB-01158; CB-1158 Phase 2 Clinical Calithera Biosciences Ovarian Neoplasms; Head and Neck Neoplasms; Biliary Tract Neoplasms; Solid tumours; Stomach Neoplasms; Carcinoma, Renal Cell; Esophageal Neoplasms; Carcinoma, Transitional Cell; Multiple Myeloma; Urinary Bladder Neoplasms; Mesothelioma; Colorectal Neoplasms; Lung Neoplasms; Endometrial Neoplasms; Neoplasm Metastasis Details

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