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FGF acidic

Brief Information

Name:Fibroblast growth factor 1
Target Synonym:Acidic fibroblast growth factor,Heparin-binding growth factor 1,HBGF-1,Endothelial cell growth factor,FGF1,Fibroblast Growth Factor 1,Endothelial Cell Growth Factor, Alpha,Endothelial Cell Growth Factor, Beta,FGF-1,AFGF,FGFA,ECGF,Beta-Endothelial Cell Gro
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
AFF-H4116 Human Human FGF acidic Protein, Tag Free
AFF-H4116-structure
AFF-H4116-sds

Part of Bioactivity data

AFF-H4116-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human FGF R1, His Tag (Cat. No. FG1-H5223) on HIS1K Biosensor, can bind Human FGF acidic, Tag Free (Cat. No. AFF-H4116) with an affinity constant of 0.16 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

AFF-H4116-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Heparin on SA Biosensor, can bind Human FGF acidic, Tag Free (Cat. No. AFF-H4116) with an affinity constant of 186 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

FGF1,AFGF,ECGF,ECGF-beta,ECGFA,ECGFB,FGF-alpha,FGFA,GLIO703,HBGF1

Background

Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF acidic is a potent growth factor for fibroblasts and endothelial cells. FGF acidic is involved in wound repair, angiogenesis, and development. FGF acidic is secreted from cells via an endoplasmic reticulum/Golgi independent mechanism. The ability of FGF acidic to bind to heparin sulfate is required for its ability to interact with FGF receptors and induce signaling. There are four distinct FGF receptors and each has multiple splice variants. FGF acidic binds with high affinity to many, but not all, FGFRs. Signaling cascades activated through FGF basic binding to FGFR include the ras-raf-MAPK, PLC¦Ã/PKC, and PI3K/Akt pathways.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Pentosan Polysulfate Sodium PPS; PZ-68; SP-54; AK-150 Approved Ivax, Teva Elmiron, Zilosul EU Cystitis, Interstitial Bene-Arzneimittel Gmbh 1996-09-26 Pain; Cystitis, Interstitial; Prostatitis; Osteoarthritis, Knee Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Muparfostat sodium PI-88 Phase 3 Clinical Australian National University Liver Neoplasms; Solid tumours; Prostatic Neoplasms; Lung Neoplasms; Carcinoma, Hepatocellular; Melanoma; Carcinoma, Non-Small-Cell Lung Details

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