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Your Position: Home > FGF R1


Brief Information

Name:Fibroblast growth factor receptor 1
Target Synonym:FGFBR,bFGF-R-1,EC:,EC 2.7.10,FLG,FLT2,CEK,BFGFR,Proto-oncogene c-Fgr,Fibroblast growth factor receptor 1,CD331,FGFR1,Basic Fibroblast Growth Factor Receptor 1,Fms-Related Tyrosine Kinase 2,FGFR-1,FLT-2,HBGFR,Heparin-Binding Growth Factor Receptor,FMS-Like Tyrosine Kinase 2,Hydroxyaryl-Protein Kinase,FGFR1/PLAG1 Fusion,Pfeiffer Syndrome,CD331 Antigen,EC,HRTFDS,N-Sam,ECCL,KAL2,HH2,OGD,Receptor, Fibroblast Growth Factor, Type 1
Number of Launched Drugs:8
Number of Drugs in Clinical Trials:17
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
FG1-H5289 Human Human FGF R1 / CD331 Protein, Strep Tag
FG1-H5223 Human Human FGF R1 / CD331 Protein, His Tag (SPR verified)

Part of Bioactivity data


Human FGF R1, His Tag (Cat. No. FG1-H5223) captured on CM5 chip via anti-His antibody can bind Human FGF acidic, Tag Free (Cat. No. FAFF-H4116) with an affinity constant of 55.9 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Synonym Name



Fibroblast growth factor receptor 1 (FGFR1) is also known as basic fibroblast growth factor receptor 1(BFGFR1), FMS-like tyrosine kinase, CD331, and is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. This protein is one of several fibroblast growth factor receptors, which are related proteins that are involved in important processes such as cell division, regulation of cell growth and maturation, formation of blood vessels, wound healing, and embryonic development.The FGFR1 protein spans the cell membrane, so that one end of the protein remains inside the cell and the other end projects from the outer surface of the cell. This positioning allows the FGFR1 protein to interact with specific growth factors outside the cell and to receive signals that help the cell respond to its environment. When growth factors attach to the FGFR1 protein, the receptor triggers a cascade of chemical reactions inside the cell that instruct the cell to undergo certain changes, such as maturing to take on specialized functions. The FGFR1 protein is thought to play an important role in the development of the nervous system. This protein may also help regulate the growth of long bones, such as the large bones in the arms and legs.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Pazopanib Hydrochloride GSK-786034; GW-786034B; SB-786034; GW-786034 Approved Glaxosmithkline Plc, Novartis Pharma Ag 维全特, Armala, Votrient, Patorma Mainland China Carcinoma, Renal Cell Novartis Pharma Schweiz Ag 2009-10-19 Urogenital Neoplasms; Prostatic Neoplasms; Osteosarcoma; Peritoneal Neoplasms; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Carcinoma, Small Cell; Leukemia, Myeloid, Acute; Sarcoma, Alveolar Soft Part; Fallopian Tube Neoplasms; Thyroid Neoplasms; Lung Neoplasms; Breast Neoplasms; Glioma; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Neoplasms; Uterine Cervical Neoplasms; Macular Degeneration; Melanoma; Neoplasm Metastasis; Carcinoma, Hepatocellular; Thyroid Cancer, Papillary; Neoplasms, Germ Cell and Embryonal; Neoplasms; Ovarian Neoplasms; Solid tumours; Chondrosarcoma; Epistaxis; Telangiectasia, Hereditary Hemorrhagic; Leiomyosarcoma; Carcinoma, Renal Cell; Hemangiosarcoma; Squamous Cell Carcinoma of Head and Neck; Thoracic Neoplasms; Head and Neck Neoplasms; Small Cell Lung Carcinoma; Glioblastoma; Pancreatic Neoplasms; Dermatofibrosarcoma; Central Nervous System Neoplasms; Lymphedema; Liposarcoma; Adenocarcinoma, Follicular; Soft Tissue Neoplasms; Sarcoma Details
Erdafitinib G-024; JNJ-493; 890E37NHMV; JNJ-42756493 Approved Astex Pharmaceuticals Inc Balversa United States Carcinoma, Transitional Cell Janssen Biotech Inc 2019-04-12 Solid tumours; Carcinoma; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma, Transitional Cell; Neoplasms; Urinary Bladder Neoplasms; Urologic Neoplasms; Bile Duct Neoplasms; Hepatic Insufficiency; Lymphoma; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details
Regorafenib DAST; BAY-73-4506 Approved Bayer AG Stivarga, Resihance Mainland China Gastrointestinal Stromal Tumors Bayer Pharma Ag 2012-09-27 Leukemia, Myeloid, Acute; Sarcoma; Gastrinoma; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Bile Duct Neoplasms; Peritoneal Neoplasms; Lymphoma, Non-Hodgkin; Lung Neoplasms; Carcinoma, Adenoid Cystic; Thyroid Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Hepatocellular; Melanoma; Neoplasm Metastasis; Gastrointestinal Neoplasms; Somatostatinoma; Solid tumours; Glucagonoma; Multiple Myeloma; Pancreatic Neoplasms; Carcinoma, Ovarian Epithelial; Carcinoma, Transitional Cell; Neoplasms; Glioblastoma; Colonic Neoplasms; Hemangiosarcoma; Carcinoma, Islet Cell; Insulinoma; Carcinoid Tumor; Rectal Neoplasms; Carcinoma, Renal Cell; Ovarian Neoplasms Details
Nintedanib Esylate BIBF-1120 Approved C.H. Boehringer Sohn Ag & Co. Kg Ofev, Vargatef EU systemic sclerosis-associated interstitial lung disease Boehringer Ingelheim International Gmbh 2014-10-15 Genital Neoplasms, Female; Sarcoma; Prostatic Neoplasms; systemic sclerosis-associated interstitial lung disease; Breast Neoplasms; Adenocarcinoma, Clear Cell; Peritoneal Neoplasms; Colorectal Neoplasms; Astrocytoma; Hepatic Insufficiency; Oligodendroglioma; Bronchitis; Silicosis; Gliosarcoma; Appendiceal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Idiopathic Pulmonary Fibrosis; Head and Neck Neoplasms; Telangiectasia, Hereditary Hemorrhagic; Bronchiolitis Obliterans; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Rejection of lung transplantation; Carcinoma, Renal Cell; Scleroderma, Systemic; Ovarian Neoplasms; Neoplasms; Carcinoma, Transitional Cell; Glioblastoma; Small Cell Lung Carcinoma; Pulmonary Fibrosis; Lung Diseases, Interstitial; Multiple Myeloma; Asbestosis Details
Pemigatinib INCB-054828; INCB-54828; IBI-375 Approved Incyte Corp Pemazyre, 伯坦, 达伯坦 Mainland China Biliary Tract Neoplasms Innovent Biologics(Suzhou) Co Ltd 2020-04-17 Glioblastoma; Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Bile Duct Neoplasms; Urologic Neoplasms; Colorectal Neoplasms; Cholangiocarcinoma; Translocation, Genetic; Urinary Bladder Neoplasms; Solid tumours; Carcinoma, Transitional Cell; Neoplasms; Pancreatic Neoplasms; Carcinoma, Renal Cell; Stomach Neoplasms; Carcinoma; Biliary Tract Neoplasms Details
Surufatinib HMPL-012 Approved Hutchison Medipharma Ltd 苏泰达, SULANDA Mainland China Neuroendocrine Tumors Hutchison Huangpu Medicine (Shanghai) Co Ltd 2020-12-29 Neuroendocrine Tumors; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Appendiceal Neoplasms; Thyroid Neoplasms; Colorectal Neoplasms; Bile Duct Neoplasms; Hepatic Insufficiency; Nasopharyngeal Carcinoma; Sarcoma; Solid tumours; Pancreatic Neoplasms; Pancreatic neuroendocrine tumors (pNET); Kidney Diseases; Neoplasms; Small Cell Lung Carcinoma; Hematologic Neoplasms; Intestinal Neoplasms; Head and Neck Neoplasms; Biliary Tract Neoplasms Details
Lenvatinib Mesylate ER-203492-00; E-7080; MK-7902 Approved Eisai Co Ltd Lenvima, Lenvima/Kisplyx, 乐卫玛, Kisplyx Japan Carcinoma, Renal Cell Merck Sharp & Dohme Corp 2015-02-13 Carcinoma, Adenoid Cystic; Thrombosis; Thyroid Cancer, Papillary; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Melanoma; Esophageal Squamous Cell Carcinoma; Endometrial Neoplasms; Lymphoma; Thyroid Neoplasms; Colorectal Neoplasms; Hepatic Insufficiency; Cholangiocarcinoma; Breast Neoplasms; Sarcoma; Neuroendocrine Tumors; Solid tumours; Urinary Bladder Neoplasms; Adenocarcinoma, Follicular; Liver Diseases; Small Cell Lung Carcinoma; Neoplasms; Kidney Diseases; Thyroid Carcinoma, Anaplastic; Adenocarcinoma of Lung; Rejection of liver transplantation; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Renal Insufficiency; Carcinoma, Renal Cell; Liver Neoplasms; Biliary Tract Neoplasms Details
Anlotinib Dihydrochloride AL-3818 Approved Advenchen Laboratories, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 福可维 Mainland China Thyroid Neoplasms Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 2018-05-08 Thyroid Neoplasms; Nasopharyngeal Carcinoma; Lymphoma, Extranodal NK-T-Cell; Cholangiocarcinoma; Bile Duct Diseases; Bone Neoplasms; Colorectal Neoplasms; Peritoneal Neoplasms; Gastrointestinal Stromal Tumors; Urologic Neoplasms; Sarcoma, Alveolar Soft Part; Endometrial Neoplasms; Gallbladder Neoplasms; Esophageal Squamous Cell Carcinoma; Medullary thyroid cancer (MTC); Carcinoma, Squamous Cell; Fallopian Tube Neoplasms; Glioma; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Melanoma; Carcinoma, Hepatocellular; Esophageal Diseases; Paraganglioma; Adenocarcinoma; Osteoma; Gastrointestinal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Leiomyosarcoma; Head and Neck Neoplasms; Biliary Tract Neoplasms; Solid tumours; Chondrosarcoma; Liver Neoplasms; Esophageal Neoplasms; Thoracic Neoplasms; Genital Diseases, Female; Stomach Neoplasms; Pheochromocytoma; Digestive System Diseases; Gastrointestinal Diseases; Ovarian Neoplasms; Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Tripl Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
BPI-17509 BPI-17509 Phase 1 Clinical Betta Pharmaceuticals Co Ltd Solid tumours Details
CPL-304110 CPL-304110; CPL-304-110 Celon Pharma Sa Details
Gunagratinib ICP-192 Phase 2 Clinical Beijing Tiancheng Pharmaceutical Technology Co Ltd Solid tumours; Biliary Tract Neoplasms; Head and Neck Neoplasms; Stomach Neoplasms; Carcinoma, Transitional Cell; Urinary Bladder Neoplasms; Lung Neoplasms Details
R-1530 RG1530; R-1530; RG-1530 F. Hoffmann-La Roche Ltd Details
LY-2874455 LY-2874455 Eli Lilly And Company Details
Tasurgratinib E-7090 Phase 2 Clinical Eisai Co Ltd Biliary Tract Neoplasms; Cholangiocarcinoma Details
TT-00434 TT-00434 Phase 1 Clinical TransThera Sciences (Nanjing) Inc Solid tumours; Urinary Bladder Neoplasms Details
HMPL-453 HMPL-453 Phase 2 Clinical Hutchison Huangpu Medicine (Shanghai) Co Ltd Biliary Tract Neoplasms; Solid tumours; Neoplasms, Mesothelial; Cholangiocarcinoma Details
DR-10624 DR-10624 Phase 1 Clinical Zhejiang Doer Biologics Corp Diabetes Mellitus, Type 2; Non-alcoholic Fatty Liver Disease; Metabolic Syndrome; Obesity; Diabetes Mellitus Details
Orantinib TSU-68; SU-6668; SU-006668 Pfizer Inc Details
XL-999 XL-999; EXEL-0999 Symphony Evolution, Exelixis, Glaxosmithkline Plc Details
HH185 3-D185; HH-185; 3D185; 3D-185 Phase 1 Clinical Shanghai Medicilon Inc, ShangHai HaiHe Biopharma Co Ltd, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Solid tumours Details
Derazantinib ARQ-087.2HCl; AQ-14741087; ARQ-087; BAL-087 Phase 1 Clinical Arqule Inc Biliary Tract Neoplasms; Carcinoma, Transitional Cell; Cholangiocarcinoma; Urogenital Neoplasms Details
KW-2449 KW-2449 Kyowa Hakko Kirin Hematologic Neoplasms Details
ASP-5878 ASP-5878 Astellas Pharma Inc Details
Rogaratinib BAY-1163877 Phase 2 Clinical Bayer AG Carcinoma, Transitional Cell; Neoplasms; Sarcoma; Gastrointestinal Stromal Tumors; Carcinoma, Non-Small-Cell Lung Details
ODM-203 ODM-203 Orion Corp Details
Fazpilodemab RG-7992; BFKB-8488A; RO-7040551 Genentech Inc Details
NGM-313 NGM-313; MK-3655 Phase 2 Clinical Ngm Biopharmaceuticals Non-alcoholic Fatty Liver Disease; Hepatitis; Obesity Details
Zoligratinib CH-5183284; FF-284; Debio-1347 Chugai Pharmaceutical Co Ltd Details
AZD-4547 ABSK-091; AZD4547; ABSK091; AZD-4547 Phase 2 Clinical Astrazeneca Plc Solid tumours; Gastrointestinal Diseases; Stomach Neoplasms; Esophageal Neoplasms; Neoplasms; Carcinoma, Transitional Cell; Urinary Bladder Neoplasms; Breast Neoplasms; Carcinoma, Squamous Cell; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung Details
PLX-5622 PLX-5622 Daiichi Sankyo Co Ltd Details
SC-0011 SC-0011 Phase 1 Clinical Shijiazhuang Zhikang Hongren New Drug Development Co Ltd Solid tumours Details
Efruxifermin AKR-001; AMG-876; EFX Phase 2 Clinical Amgen Inc Non-alcoholic Fatty Liver Disease; Diabetes Mellitus Details
Lucitanib AL-3810; CO-3810; S-80881 Phase 3 Clinical Advenchen Laboratories Nanjing Ltd Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Neoplasms; Small Cell Lung Carcinoma; Carcinoma, Transitional Cell; Triple Negative Breast Neoplasms; Nasopharyngeal Carcinoma; Breast Neoplasms; Colorectal Neoplasms; Genital Neoplasms, Female; Thymus Neoplasms; Carcinoma, Small Cell; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details

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