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FGF R1

Brief Information

Name:Fibroblast growth factor receptor 1
Target Synonym:FLG,FLT2,CEK,BFGFR,FGFBR,bFGF-R-1,Proto-oncogene c-Fgr,Fibroblast growth factor receptor 1,CD331,FGFR1,Basic Fibroblast Growth Factor Receptor 1,Fms-Related Tyrosine Kinase 2,FGFR-1,FLT-2,HBGFR,Heparin-Binding Growth Factor Receptor,FMS-Like Tyrosine Kina
Number of Launched Drugs:7
Number of Drugs in Clinical Trials:16
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
FG1-H5289 Human Human FGF R1 / CD331 Protein, Strep Tag
FG1-H5289-structure
FG1-H5289-sds
FG1-H5223 Human Human FGF R1 / CD331 Protein, His Tag
FG1-H5223-structure
FG1-H5223-sds
FG1-H5223-elisa_1

Part of Bioactivity data

FG1-H5223-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human FGF R1, His Tag (Cat. No. FG1-H5223) on HIS1K Biosensor, can bind Human FGF acidic, Tag Free (Cat. No. AFF-H4116) with an affinity constant of 0.16 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

FG1-H5223-ELISA
Human FGF R1, His TagHuman FGF R1, His Tag (Cat. No. FG1-H5223) ELISA bioactivity

Immobilized Human FGF basic, Tag Free (Cat. No. BFF-H4117) at 5 μg/mL (100 μL/well) can bind Human FGF R1, His Tag (Cat. No. FG1-H5223) with a linear range of 0.156-1.25 μg/mL (QC tested).

Synonym Name

FGFR1,BFGFR,CD331,CEK,FGFBR,FLG,HBGFR,N-SAM,FLT2,H2,KAL2,FLJ14326

Background

Fibroblast growth factor receptor 1 (FGFR1) is also known as basic fibroblast growth factor receptor 1(BFGFR1), FMS-like tyrosine kinase, CD331, and is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. This protein is one of several fibroblast growth factor receptors, which are related proteins that are involved in important processes such as cell division, regulation of cell growth and maturation, formation of blood vessels, wound healing, and embryonic development.The FGFR1 protein spans the cell membrane, so that one end of the protein remains inside the cell and the other end projects from the outer surface of the cell. This positioning allows the FGFR1 protein to interact with specific growth factors outside the cell and to receive signals that help the cell respond to its environment. When growth factors attach to the FGFR1 protein, the receptor triggers a cascade of chemical reactions inside the cell that instruct the cell to undergo certain changes, such as maturing to take on specialized functions. The FGFR1 protein is thought to play an important role in the development of the nervous system. This protein may also help regulate the growth of long bones, such as the large bones in the arms and legs.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Pazopanib Hydrochloride GW-786034; SB-786034; GSK-786034; GW-786034B Approved Glaxosmithkline Plc, Novartis Pharma Ag 维全特, Armala, Patorma, Votrient Mainland China Carcinoma, Renal Cell Novartis Pharma Schweiz Ag 2009-10-19 Osteosarcoma; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Melanoma; Carcinoma, Hepatocellular; Fallopian Tube Neoplasms; Glioma; Peritoneal Neoplasms; Colorectal Neoplasms; Prostatic Neoplasms; Ovarian Neoplasms; Breast Neoplasms; Sarcoma; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Hemangiosarcoma; Carcinoma, Renal Cell; Solid tumours; Chondrosarcoma; Telangiectasia, Hereditary Hemorrhagic Details
Erdafitinib G-024; JNJ-493; 890E37NHMV; JNJ-42756493 Approved Astex Pharmaceuticals Inc Balversa United States Carcinoma, Transitional Cell Janssen Biotech Inc 2019-04-12 Solid tumours; Carcinoma; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma, Transitional Cell; Urinary Bladder Neoplasms; Bile Duct Neoplasms; Urologic Neoplasms; Hepatic Insufficiency; Lymphoma; Carcinoma, Hepatocellular; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung Details
Regorafenib Monohydrate BAY-73-4506; DAST Approved Bayer Ag Stivarga, Resihance Mainland China Gastrointestinal Stromal Tumors Bayer Pharma Ag 2012-09-27 Solid tumours; Rectal Neoplasms; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Carcinoma, Hepatocellular; Gastrointestinal Neoplasms Details
Pemigatinib IBI-375; INCB-054828; INCB-54828; BH-009 Approved Incyte Corp Pemazyre, 达伯坦, 伯坦 Taiwan Cholangiocarcinoma Incyte Corp 2020-04-17 Biliary Tract Neoplasms; Solid tumours; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Cholangiocarcinoma; Translocation, Genetic; Bile Duct Neoplasms; Endometrial Neoplasms Details
Anlotinib Dihydrochloride AL-3818 Approved Advenchen Laboratories, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 福可维 Mainland China Small Cell Lung Carcinoma Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd 2018-05-08 Esophageal Squamous Cell Carcinoma; Nasopharyngeal Carcinoma; Gastrointestinal Stromal Tumors; Bone Neoplasms; Peritoneal Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Thyroid Neoplasms; Sarcoma, Alveolar Soft Part; Cholangiocarcinoma; Lung Neoplasms; Fallopian Tube Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Melanoma; Adenocarcinoma; Osteoma; Triple Negative Breast Neoplasms; Solid tumours; Ovarian Neoplasms; Leiomyosarcoma; Liver Neoplasms; Genital Diseases, Female; Carcinoma, Renal Cell; Stomach Neoplasms; Esophageal Neoplasms; Biliary Tract Neoplasms; Small Cell Lung Carcinoma; Lymphoma, Large B-Cell, Diffuse; Carcinoma, Ovarian Epithelial; Sarcoma, Synovial; Neuroendocrine Tumors; Medullary thyroid cancer (MTC); Sarcoma Details
Infigratinib BGJ-398; NVP-BGJ398 Approved Novartis Pharma Ag TRUSELTIQ United States Cholangiocarcinoma Qed Therapeutics Inc 2021-05-28 Solid tumours; Biliary Tract Neoplasms; Hematologic Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Carcinoma, Transitional Cell; Achondroplasia; Urinary Bladder Neoplasms; Cholangiocarcinoma; Carcinoma, Squamous Cell; Melanoma Details
Nintedanib Esylate BIBF-1120 Approved C.H. Boehringer Sohn Ag & Co. Kg Ofev, Vargatef Mainland China Idiopathic Pulmonary Fibrosis Boehringer Ingelheim International Gmbh 2014-10-15 Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Scleroderma, Systemic; Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis; Lung Diseases, Interstitial; Multiple Myeloma; Prostatic Neoplasms; Peritoneal Neoplasms; Hepatic Insufficiency; Genital Neoplasms, Female; Colorectal Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
Surufatinib HMPL-012 Approved Hutchison Medipharma Ltd 苏泰达, SULANDA Mainland China Neuroendocrine Tumors Hutchison Huangpu Medicine (Shanghai) Co Ltd 2020-12-29 Biliary Tract Neoplasms; Pancreatic neuroendocrine tumors (pNET); Neoplasms; Kidney Diseases; Neuroendocrine Tumors; Bile Duct Neoplasms; Hepatic Insufficiency; Thyroid Neoplasms; Carcinoma, Neuroendocrine Details
Lenvatinib Mesylate ER-203492-00; E-7080 Approved Eisai Co Ltd Kisplyx, Lenvima, Lenvima/Kisplyx, 乐卫玛 United States Endometrial Neoplasms Eisai Inc 2015-02-13 Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Gallbladder Neoplasms; Lymphoma; Endometrial Neoplasms; Thyroid Neoplasms; Hepatic Insufficiency; Cholangiocarcinoma; Sarcoma; Liver Diseases; Liver Neoplasms; Triple Negative Breast Neoplasms; Kidney Diseases; Small Cell Lung Carcinoma; Thyroid Carcinoma, Anaplastic; Adenocarcinoma of Lung; Esophageal Neoplasms; Renal Insufficiency; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Biliary Tract Neoplasms; Solid tumours Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
RG-7992 RG-7992; BFKB-8488A; RO-7040551 Phase 2 Clinical Genentech Inc Non-alcoholic Fatty Liver Disease; Diabetes Mellitus, Type 2; Insulin Resistance Details
Brivanib Alaninate ZL-2301; BMS-540215; BMS-582664 Phase 3 Clinical Bristol-Myers Squibb Company Solid tumours; Liver Neoplasms; Rectal Neoplasms; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Sarcoma; Colorectal Neoplasms; Gastrointestinal Neoplasms; Neoplasm Metastasis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung Details
S-49076 S-49076 Phase 2 Clinical Servier Glioblastoma; Carcinoma, Non-Small-Cell Lung Details
LY-2874455 LY-2874455 Phase 2 Clinical Eli Lilly And Company Neoplasms Details
E-7090 E-7090 Phase 2 Clinical Eisai Co Ltd Biliary Tract Neoplasms; Cholangiocarcinoma; Breast Neoplasms; Hepatic Insufficiency Details
HMPL-453 tartrate Phase 2 Clinical Hutchison Huangpu Medicine (Shanghai) Co Ltd Biliary Tract Neoplasms; Solid tumours; Head and Neck Neoplasms; Hematologic Neoplasms; Leukemia, Myeloid; Neoplasms, Mesothelial; Stomach Neoplasms; Esophageal Neoplasms; Mesothelioma; Multiple Myeloma; Urinary Bladder Neoplasms; Breast Neoplasms; Bile Duct Neoplasms; Carcinoma, Non-Small-Cell Lung Details
PRN-1371 PRN-1371 Phase 1 Clinical Principia Biopharma Inc Solid tumours; Urinary Bladder Neoplasms Details
CH-5183284 FF-284; CH-5183284; Debio-1347 Phase 2 Clinical F. Hoffmann-La Roche Ltd Solid tumours; Breast Neoplasms Details
Lucitanib AL-3810; CO-3810; S-80881 Phase 3 Clinical Advenchen Laboratories Nanjing Ltd Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Carcinoma, Transitional Cell; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Breast Neoplasms; Nasopharyngeal Carcinoma; Colorectal Neoplasms; Thymus Neoplasms; Genital Neoplasms, Female; Carcinoma, Small Cell; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular Details
Recombinant human keratinocyte growth factor-2 (Guangdong Jida Gene Research Center) Phase 1 Clinical Guangzhou Jida Gene Pharmacy Engineering Research Center Co Ltd Keratitis; Corneal Injuries; Corneal Diseases Details
BPI-17509 BPI-17509 Phase 1 Clinical Betta Pharmaceuticals Co Ltd Solid tumours Details
TT-00434 TT-00434 Phase 1 Clinical Yaojie Ankang (Nanjing) Technology Co Ltd Solid tumours; Urinary Bladder Neoplasms Details
HH185 3-D185; HH-185; 3D185; 3D-185 Phase 1 Clinical Shanghai Medicilon Inc, ShangHai HaiHe Biopharma Co Ltd, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Solid tumours Details
Futibatinib TAS-120 Phase 3 Clinical Otsuka Pharmaceutical Co Ltd, Taiho Pharmaceutical Co Ltd Bone Marrow Neoplasms; Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma; Carcinoma, Transitional Cell; Brain Neoplasms; Cholangiocarcinoma; Breast Neoplasms; Lymphoma; Carcinoma, Non-Small-Cell Lung Details
NGM-313 MK-3655; NGM-313 Phase 2 Clinical Ngm Biopharmaceuticals Non-alcoholic Fatty Liver Disease; Hepatitis; Obesity Details

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