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Fibroblast growth factor receptor 5 (FGFR-5) is also known as Fibroblast growth factor receptor-like 1 (FGFRL1), FGF homologous factor receptor (FHFR), is a single-pass type I membrane protein. FGFRL1 / FGFR5 contains three Ig-like C2-type (immunoglobulin-like) domains. FGFR-5 is expressed preferentially in cartilaginous tissues and pancreas and highly expressed in the liver, kidney, heart, brain and skeletal muscle. FGF RL1 / FGFR5 has a negative effect on cell proliferation. FGFR5 interacts with FGF2 with a low affinity.

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