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FKBP12

FKBP12 Molecule Information

Name:FK506-binding protein 1A
Target Synonym:FKBP12;12 kDa FKBP;FKBP-1A;FKBP1 ;FKBP1A;PPIase FKBP1A;Immunophilin FKBP12;Peptidyl-prolyl cis-trans isomerase FKBP1A;FKBP-12;Calstabin-1;FK506-binding protein 1A;Rotamase;12 kDa FK506-binding protein
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
FKA-H5122 Human Human FKBP12 / FKBP1A Protein, His Tag
FKA-H5122-structure
FKA-H5122-sds

FKBP12 Molecule Synonym Name

FKBP1A,FKBP1,Calstabin-1,FKBP12,Rotamase,PKC12,PPIASE

FKBP12 Molecule Background

Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus).FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.

FKBP12 References

FKBP12 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Tacrolimus Hydrate FK-506; FK-506E; FK-506MR; FR-900506; L-679934; MR-4; RTU-007; LCP-Tacro Approved Astellas PROGRAF fda ASTELLAS 1994-04-08 Ulcerative colitis, Myasthenia, Lupus nephritis, Transplant rejection, Atopic dermatitis, Coronary restenosis, Rheumatoid arthritis (RA), Allergic conjunctivitis Details

FKBP12 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Rimiducid AP-1903,AP1903 Phase Ⅱ Ariad, Bellicum Myelodysplastic syndrome (MDS), Acute myeloid Leukemia (AML), Acute lymphoblastic leukaemia (ALL), Non-Hodgkin's lymphoma (NHL) Details

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