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Brief Information

Target Synonym:hFz4,FzE4,CD344,Frizzled 4, Seven Transmembrane Spanning Receptor,Fz-4,Frizzled Family Receptor 4,EVR1,Frizzled (Drosophila) Homolog 4,Frizzled Homolog 4 (Drosophila),Exudative Vitreoretinopathy 1,WNT Receptor Frizzled-4,Frizzled Homolog 4,CD344 Antigen,FZD4S,FEVR,GPCR,Fz4
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Cat. No. Species Product Description Structure Purity Feature
FZ4-H5250 Human Human Frizzled-4 / FZD4 Protein, Fc Tag
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Frizzled-4 (FZD4) is also known as FzE4, CD344, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD4 contains one FZ (frizzled) domain. FZD4 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD4 interacts with MAGI3 and norrin (NDP).

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