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Your Position: Home > Frizzled-7

Frizzled-7

Brief Information

Name:Frizzled-7
Target Synonym:FZD7,Frizzled-7,hFz7,Fz-7,Frizzled Class Receptor 7,Frizzled 7, Seven Transmembrane Spanning Receptor,Frizzled Family Receptor 7,FzE3,Frizzled, Drosophila, Homolog Of, 7,Frizzled (Drosophila) Homolog 7,Frizzled Homolog 7,Frizzled Homolog 7 (Drosophila)
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
FZ7-H52H9 Human Human Frizzled-7 / FZD7 Protein, His Tag
FZ7-H52H9-structure
FZ7-H52H9-sds
FZ7-H5258 Human Human Frizzled-7 / FZD7 Protein, Fc Tag
FZ7-H5258-structure
FZ7-H5258-sds
ACRO Quality

Part of Bioactivity data

FZ7-H52H9-BLI
Frizzled-7 BLI

Loaded Biotinylated Human Glypican 3, His,Avitag, premium grade (Cat. No. GP3-H82E5) on SA Biosensor, can bind Human Frizzled-7, His Tag (Cat. No. FZ7-H52H9) with an affinity constant of 1.18 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
FZ7-H5258-ELISA
Frizzled-7 ELISA

Immobilized Human Frizzled-7, Fc Tag (Cat. No. FZ7-H5258) at 1 μg/mL (100 μL/well) can bind Wnt surrogate Human IgG1(D239E,L241M) | Human Lambda with a linear range of 0.1-8 ng/mL (QC tested).

Protocol

Synonym Name

FZD7,Frizzled-7,FzE3,Fz-7,hFz7

Background

Frizzled-7 (FZD7) is also known as FzE3, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD7 contains one FZ (frizzled) domain. FZD7 is receptor for Wnt proteins. FZD7 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD7 interacts with MAGI3 and DVL1.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Vantictumab OMP-18R5; anti-Fzd7 Phase 1 Clinical Oncomed Pharmaceuticals Inc, Bayer AG Solid tumours; Pancreatic Neoplasms; Metastatic breast cancer; Carcinoma, Non-Small-Cell Lung Details

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