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GALC

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Synonym Name

GALCERase,Galactocerebrosidase,GALC

Background

Galactocerebrosidase (GALC) is also known as GALCERase, Galactocerebroside beta-galactosidase, Galactosylceramidase and Galactosylceramide beta-galactosidase, which belongs to the glycosyl hydrolase 59 family. Galactocerebrosidase / GALC hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. GALC with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon. Defects in Galc are the cause of the 'twitcher' phenotype.

Clinical and Translational Updates

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